The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
How Do Microtubule-Targeted Drugs Work? An Overview
Abstract
The importance of microtubules in mitosis makes them a superb target for a group of highly successful, chemically diverse anticancer drugs. Knowledge of the mechanistic differences among the many drugs of this class is vital to understanding their tissue and cell specificity, the development of resistance, the design of novel improved drugs, optimal scheduling of treatment, and potential synergistic combinations. This overview covers microtubule assembly dynamics, the exquisite regulation of microtubule dynamics in cells by endogenous regulators, the important role of microtubule dynamics in mitosis, the diversity and number of microtubule-targeted drugs undergoing clinical development, the antimitotic mechanisms of microtubule-targeted drugs with emphasis on suppression of microtubule dynamics by vinblastine and taxol, the role of drug uptake and retention in the efficacy of microtubule-targeted drugs, and the anti-angiogenic and vascular-disrupting mechanisms of microtubule targeted drugs. In view of the success of this class of drugs, it has been argued that microtubules represent the single best cancer target identified to date, and it seems likely that drugs in this class will continue to remain an important chemotherapeutic class of drugs even as more selective chemotherapeutic approaches are developed.
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Citations
Cites
Microtubules as a target for anticancer drugs
Jordan, M. A., & Wilson, L. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1317 · Cited by 4,000
Self-citationDynamic instability of microtubule growth
Mitchison, T., & Kirschner, M. (1984) · Nature · doi:10.1038/312237a0 · Cited by 3,337
Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations.
Jordan, M. A., Toso, R. J., Thrower, D., & Wilson, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9552 · Cited by 1,095
Self-citationDisrupting tumour blood vessels
Tozer, G. M., Kanthou, C., & Baguley, B. C. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1628 · Cited by 930
Mechanism of Action of Antitumor Drugs that Interact with Microtubules and Tubulin
Jordan, M. (2012) · Current Medicinal Chemistry-Anti-Cancer Agents · doi:10.2174/1568011023354290 · Cited by 775
Self-citationJordan, M. A., Wendell, K., Gardiner, S., Derry, W. B., Copp, H., & Wilson, L. (1996) · PubMed · Cited by 770
Self-citation2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
Mabjeesh, N. J., Escuin, D., LaVallee, T. M., Pribluda, V. S., Swartz, G. M., Johnson, M. S., Willard, M. T., Zhong, H., Simons, J. W., & Giannakakou, P. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00077-1 · Cited by 730
Kin I kinesins are microtubule-destabilizing enzymes
Desai, A., Verma, S., Mitchison, T. J., & Walczak, C. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80960-5 · Cited by 708
Taxol binds to polymerized tubulin in vitro
Parness, J., & Horwitz, S. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.91.2.479 · Cited by 620
Multiple Forms of Tubulin: Different Gene Products and Covalent Modifications
Ludueña, R. F. (1997) · International Review of Cytology · doi:10.1016/s0074-7696(08)62138-5 · Cited by 611
Cited by
Mitosis is not a key target of microtubule agents in patient tumors
Komlodi-Pasztor, E., Sackett, D., Wilkerson, J., & Fojo, T. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.228 · Cited by 314
Pourgholami, M. H., Szwajcer, M., Chin, M., Liauw, W., Seef, J., Galettis, P., Morris, D. L., & Links, M. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-009-1157-8 · Cited by 69
Genetically encoded live-cell sensor for tyrosinated microtubules
Kesarwani, S., Lama, P., Chandra, A., Reddy, P. P., Jijumon, A. S., Bodakuntla, S., Rao, B. M., Janke, C., Das, R., & Sirajuddin, M. (2020) · Journal of Cell Biology · doi:10.1083/jcb.201912107 · Cited by 37
Metadata
- Authors
- Jordan, M., & Kamath, K.
- Venue
- Current Cancer Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2007-12-01
- Volume
- 7
- Issue
- 8
- Pages
- 730-742
- ISSN
- 1568-0096 (ISSN-L)
- OpenAlex
- W2049970665
- Cited by
- 270
- References
- 147
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
