Stat3 Orchestrates Tumor Development and Progression: The Achilles Heel of Head and Neck Cancers?
Abstract
Despite recent advancements in treatment modalities, the overall survival and quality of life of patients with head and neck squamous cell carcinoma (HNSCC) have not improved significantly over the past decade. With the increasing emergency of new biological agents, the development of novel treatment schemes based on cancer cell biology may be promising for this group of patients. We previously introduced the "oncogene addiction" concept as a rationale for molecular targeting in cancer therapy and prevention. In this context, an increasing number of preclinical studies have demonstrated that the Signal Transducers and Activators of transcription 3 (Stat3) transcription factor plays critical roles in the development and progression of a variety of tumors including HNSCC, by regulating cell proliferation, cell cycle progression, apoptosis, angiogenesis, immune evasion, Epithelial-Mesenchymal Transition (EMT) and through effects in cancer stem cells. The purpose of this review is to summarize current experimental and clinical evidence that suggest that HNSCC might be addicted to Stat3 and describe the molecular mechanisms that may explain this phenomenon. In addition, we discuss whether this addiction is an exploitable target for developing approaches for the treatment and prevention of HNSCC.
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Inhibition of aberrant STAT3 activation is a compelling target for HNSCC and CRC.
“the inhibition of aberrant STAT3 activation emerges as a compelling HNSCC and CRC target (8, 14, 15).”
From Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer (2022) · cites this paper as [14]
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Self-citation
- Authors
- Masuda, M., Wakasaki, T., Suzui, M., Toh, S., Joe, A., & Weinstein, I.
- Affiliations
- Gifu Pharmaceutical University (JP)
- Columbia University (US)
- Venue
- Current Cancer Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2010-02-01
- Volume
- 10
- Issue
- 1
- Pages
- 117-126
- ISSN
- 1568-0096 (ISSN-L)
- OpenAlex
- W2130415549
- Cited by
- 60
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 12 · 2012: 8
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Cancer Drug Targets (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- STAT3, head and neck squamous cell carcinoma, oncogene addiction, tumor progression, targeted therapy, epithelial-mesenchymal transition, cancer stem cells, angiogenesis, immune evasion, apoptosis, cell proliferation, cancer prevention
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Head and Neck Neoplasms, Humans, Neovascularization, Pathologic, Apoptosis, Neoplasms, Squamous Cell, Drug Resistance, Neoplasm, Tumor Escape, Proto-Oncogene Proteins c-bcl-2, Cell Proliferation, STAT3 Transcription Factor, Mice
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