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Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry
Open accessAbstract
The impact of the development of sulfur therapeutics is instrumental to the evolution of the pharmaceutical industry. Sulfur-derived functional groups can be found in a broad range of pharmaceuticals and natural products. For centuries, sulfur continues to maintain its status as the dominating heteroatom integrated into a set of 362 sulfur-containing FDA approved drugs (besides oxygen or nitrogen) through the present. Sulfonamides, thioethers, sulfones and Penicillin are the most common scaffolds in sulfur containing drugs, which are well studied both on synthesis and application during the past decades. In this review, these four moieties in pharmaceuticals and recent advances in the synthesis of the corresponding core scaffolds are presented.
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Thase, M. E., Macfadden, W., Weisler, R. H., Chang, W., Paulsson, B., Khan, A., & Calabrese, J. R. (2006) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000248603.76231.b7 · Cited by 559
Cited by
Hofman, K., Liu, N., & Manolikakes, G. (2018) · Chemistry – A European Journal · doi:10.1002/chem.201705470 · Cited by 283
Gizińska, M., Staniszewska, M., & Ochal, Z. (2018) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557518666180924121209 · Cited by 15
Metadata
- Authors
- Feng, M., Tang, B., H. Liang, S., & Jiang, X.
- Venue
- Current Topics in Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2016-03-03
- Volume
- 16
- Issue
- 11
- Pages
- 1200-1216
- ISSN
- 1568-0266 (ISSN-L)
- OpenAlex
- W2331484215
- Cited by
- 2,015
- References
- 1
- FWCI
- 44.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Feng, M., Tang, B., H. Liang, S., & Jiang, X. (2016). Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry. Current Topics in Medicinal Chemistry. https://doi.org/10.2174/1568026615666150915111741
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
