Relationship between atopic dermatitis and food allergy
Open accessAbstract
Consistent evidence has been found on the relationship between food allergy (FA) and atopic dermatitis (AD) in some children. Food sensitization can be often found in these patients. Allergy should be confirmed, though, with a food challenge test (FC) before advising a restrictive diet which could be harmful for the patient. Younger children with AD frequently show sensitization to egg, milk or peanut, while older ones and adults are more often sensitized to environmental allergens such as house dust mites, moulds, animal dander or pollens. It is well known that a barrier disturbance plays a main role in the development of sensitization and allergy. Therefore, due to the early appearance of AD, preventive newborn skincare with emollients and early introduction of food appear to be very important to determine food tolerance.
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Early-onset AD is related to the development of food allergies.
“In short, early-onset AD is related to the development of food allergies.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [14]
By penetrating the compromised skin barrier of AD, intact allergens can be captured, processed, and presented by antigen-presenting cells via IgE-facilitated presentation.
“By penetrating the compromised skin barrier of AD, intact allergens can be captured, processed, and presented by antigen-presenting cells via IgE-facilitated presentation.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [14]
The IgE-antigen complex is internalized and degraded, with subsequent antigen presentation in the major histocompatibility complex class II to T lymphocytes.
“The IgE-antigen complex is then internalized and degraded, with subsequent antigen presentation in the major histocompatibility complex class II to T lymphocytes.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [14]
Serum IgE values are associated with respiratory, but not cutaneous, disease activity.
“In fact, serum IgE values are associated with respiratory, but not cutaneous, disease activity.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [14]
Several studies have confirmed an association between food allergies and more severe AD, as well as an association between early and persistent development of AD and food allergies, with greater likelihood of sensitization to milk, eggs, and peanuts.
“Several studies have confirmed an association between food allergies and more severe AD, as well as an association between the early and persistent development of AD and food allergies, observing a greater likelihood of sensitization to common foods such as milk, eggs, and peanuts.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [14]
Food allergy worsens AD or increases the risk of comorbidities, including anaphylaxis.
“Conversely, food allergy worsens AD or increases the risk of comorbidities, including anaphylaxis.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [14]
Exposure to aeroallergens can trigger skin reactions in AD, suggesting direct contact with the skin as the main stimulus route.
“Exposure to aeroallergens can trigger skin reactions in AD, suggesting direct contact with the skin as the main stimulus route.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [14]
Cites
1 retracted
RETRACTED: Skin barrier impairment at birth predicts food allergy at 2 years of age
Kelleher, M. M., Dunn-Galvin, A., Gray, C., Murray, D. M., Kiely, M., Kenny, L., McLean, W. H. I., Irvine, A. D., & Hourihane, J. O. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.12.1312 · Cited by 169 · see citing works
RetractedEpidemiologic risks for food allergy
Lack, G. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.04.032 · Cited by 700 · see citing works
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Update on the pathogenesis of atopic dermatitis.
Criado, P. R., Miot, H. A., Bueno-Filho, R., Ianhez, M., Criado, R. F. J., & de Castro, C. C. S. (2024) · Anais brasileiros de dermatologia · doi:10.1016/j.abd.2024.06.001 · Cited by 66 · see citing works
- Authors
- Domínguez, O., Plaza, A. M., & Alvaro, M.
- Affiliations
- Hospital Sant Joan de Déu Barcelona (ES)
- Department of Allergy and Clinical Immunology, Hospital Sant Joan de Déu, Barcelona, Spain
- Corresponding author
- Domínguez, Olga
- Venue
- Current Pediatric Reviews
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2020-07-01
- Volume
- 16
- Issue
- 2
- Pages
- 115-122
- ISSN
- 1573-3963 (ISSN-L)
- OpenAlex
- W2988133489
- Cited by
- 37
- References
- 2
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 9 · 2023: 11 · 2022: 2 · 2021: 2 · 2020: 1
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Current Pediatric Reviews (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Surgery › Eosinophilic Esophagitis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- atopic dermatitis, food allergy, food sensitization, oral food challenge, dietary restriction, egg allergy, cow's milk allergy, peanut allergy, house dust mites, barrier dysfunction, emollients, early introduction of complementary foods, food tolerance, pediatric allergy
- MeSH terms
- Breast Feeding, Child, Child, Preschool, Combined Modality Therapy, Dermatitis, Atopic, Dermatologic Agents, Diet Therapy, Emollients, Food Hypersensitivity, Humans, Infant, Infant, Newborn, Phenotype, Risk Factors, Vitamins, Dietary Supplements, Probiotics, Prebiotics
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