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Amyotrophic Lateral Sclerosis and Oxidative Stress: A Double-Blind Therapeutic Trial After Curcumin Supplementation
Abstract
Objective: To investigate the efficacy of curcumin oral supplementation (600 mg/day, Brainoil), a natural antioxidant compound, in Amyotrophic Lateral Sclerosis (ALS). Methods: Patients were randomized into two groups: Group A received placebo for 3 months, then Brainoil for the following 3 months, Group B took Brainoil for 6 months. The evaluations were conducted at basal (T0), after 3 months of double blinded Brainoil or placebo treatment (T1), and after the 3 month open-label phase (T2). Clinical evaluations and oxidative stress biomarkers, including oxidative protein products (AOPPs), ferric reducing ability (FRAP), total thiols (T-SH) and lactate, were evaluated, compared to a control group, during an incremental forearm exercise test. Results: Over the entire study Group B showed a stable score of the ALS-FRS-r which decreased in Group A (p<0.01), in parallel with a reduction of AOPPs (p<0.01) which was not detected into Group A. Also FRAP exercise values remained stable in Group B, while in Group A they were reduced without treatment at T1 (0.05<p<0.01), for then increase at T2 with introduction of therapy (p<0.05). In Group B T1>T0 exercise lactate was lower compared to Group A (p<0.01). Compared to controls, the whole ALS population showed a greater oxidative stress (p<0.001), those treated with curcumin (Group B) exhibiting decreased exercise AOPPs at T2 with values approaching those of controls. Conclusion: Although further studies are needed to confirm these data, treatment with curcumin shows encouraging results indicating a slight slowdown in disease progression, improving aerobic metabolism and oxidative damage, this also contributing to deepen knowledge into the pathogenic mechanisms of ALS.
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Supplementation of the diets of ALS patients with curcumin, a non-flavonoid polyphenol, resulted in no clear progression of the disease after 6 months of follow-up.
“Chico et al. (108) supplemented the diets of ALS patients with curcumin, a non-flavonoid polyphenol, and observed no clear progression of the disease after 6 months of follow-up.”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [108]
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Yan, L., Guo, M.-S., Zhang, Y., Yu, L., Wu, J.-M., Tang, Y., Ai, W., Zhu, F.-D., Law, B. Y.-K., Chen, Q., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5288698 · Cited by 97
Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38
Metadata
- Authors
- Chico, L., Ienco, E. C., Bisordi, C., Lo Gerfo, A., Petrozzi, L., Petrucci, A., Mancuso, M., & Siciliano, G.
- Affiliations
- University of Pisa (IT)
- Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Pisa, Italy
- Azienda Ospedaliera San Camillo-Forlanini (IT)
- Corresponding author
- Chico, Lucia
- ORCID
- Venue
- CNS & Neurological Disorders - Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2018-11-23
- Volume
- 17
- Issue
- 10
- Pages
- 767-779
- ISSN
- 1568-007X (ISSN-L)
- 1871-5273
- OpenAlex
- W2884528651
- Cited by
- 95
- References
- 34
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 12 · 2023: 22 · 2022: 17 · 2021: 14 · 2020: 10 · 2019: 4
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS & Neurological Disorders - Drug Targets (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- amyotrophic lateral sclerosis, curcumin, oxidative stress, antioxidant supplementation, ferric reducing ability, total thiol, aerobic metabolism, disease progression, ALSFRS-R
- MeSH terms
- Superoxide Dismutase-1, Aged, Amyotrophic Lateral Sclerosis, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Curcumin, Double-Blind Method, Exercise Test, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mutation, Severity of Illness Index, Sulfhydryl Compounds, Time Factors, Body Mass Index, Treatment Outcome, Oxidative Stress, Hand Strength, Lactic Acid, Dietary Supplements, Advanced Oxidation Protein Products
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