The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Chronic Inflammation and Oxidative Stress as a Major Cause of Age- Related Diseases and Cancer
Abstract
Chronic inflammation is a pathological condition characterized by continued active inflammation response and tissue destruction. Many of the immune cells including macrophages, neutrophils and eosinophils are involved directly or by production of inflammatory cytokine production in pathology of chronic inflammation. From literatures, it is appear that there is a general concept that chronic inflammation can be a major cause of cancers and express aging processes. Moreover, many studies suggest that chronic inflammation could have serious role in wide variety of age-related diseases including diabetes, cardiovascular and autoimmune diseases. Inflammatory process induces oxidative stress and reduces cellular antioxidant capacity. Overproduced free radicals react with cell membrane fatty acids and proteins impairing their function permanently. In addition, free radicals can lead to mutation and DNA damage that can be a predisposing factor for cancer and age-related disorders. This article reviews the antioxidant defense systems, free radicals production and their role in cancer and age related diseases and also some of the recent patent relevant to the field. Study of the role of free radicals in human diseases can help the investigators to consider the antioxidants as proper agents in preventive medicine, especially for cancer and aging processes.
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Cites
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Cited by
Oxidative stress, aging, and diseases
Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., et al. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s158513 · Cited by 3,979
Nrf2 signaling pathway: pivotal roles in inflammation
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Small Molecule Modulators of Keap1‐ Nrf2‐ ARE Pathway as Potential Preventive and Therapeutic Agents
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Metadata
- Authors
- Khansari, N., Shakiba, Y., & Mahmoudi, M.
- Venue
- Recent Patents on Inflammation & Allergy Drug Discovery
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2009-01-01
- Volume
- 3
- Issue
- 1
- Pages
- 73-80
- ISSN
- 1872-213X (ISSN-L)
- OpenAlex
- W2096401930
- Cited by
- 921
- References
- 10
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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