Cited by 372Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

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Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity.

Cowansage, Kiriana, LeDoux, Joseph, Monfils, Marie-H.·2010·Current Molecular Pharmacology

DOI 10.2174/1874467211003010012

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Abstract

Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family of structurally related proteins that promote neuronal differentiation and survival during development, is a potent modulator of synaptic plasticity. Changes in BDNF expression, release and neuromodulatory activity, mediated by both epigenetic and post-translational mechanisms, have been associated with many pathological conditions and developmental experiences, such as maternal deprivation and environmental enrichment. Much effort has been devoted to studying plasticity in the hippocampus, a structure traditionally associated with learning and memory, yet there is increasing empirical support for the contribution of another structure--the amygdala--to BDNF-induced changes. Because the amygdala is a critical site for emotional memory formation, and many emotional and neurodevelopmental pathologies have been linked to amygdala-based abnormalities, considerable efforts have been devoted to the characterization of its circuitry. Here we review the role of BDNF as a biochemical integrator of convergent cellular signals, and as a central driver of neural plasticity. We conclude by emphasizing the importance of characterizing BDNF signaling cascades in behaviorally-relevant networks, to identify potential drug targets for novel therapeutic interventions.

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Background
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BackgroundInfluential
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Background
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Background
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“BDNF, a key player in neuronal plasticity (Cowansage et al., 2010), was shown to be secreted depending on ERK1/2 signaling in vitro (Miao et al., 2012) by activated microglia in spinal cord slice cultures modulating synaptic potentials (Coull et al., 2005) and to stimulate Gap43 expression and…”
Background
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Background
Sox11 modulates brain‐derived neurotrophic factor expression in an exon promoter‐specific manner
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Background
Environmental enrichment induces behavioural disturbances in neuropeptide Y knockout mice
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Background
Robust changes in expression of brain-derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma
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“BDNF production and release is subject to regulation by epigenetic mechanisms and neuronal activity (Cowansage et al. 2010).”
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Influential
Prominent Postsynaptic and Dendritic Exocytosis of Endogenous BDNF Vesicles in BDNF-GFP Knock-in Mice
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“proBDNF, the precursor of BDNF, exerts opposing effects on BDNF (Cowansage et al. 2010).”
BackgroundResultInfluential
Polysaccharide from Polygala tenuifolia alleviates cognitive decline in Alzheimer's disease mice by alleviating Aβ damage and targeting the ERK pathway
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Studies on medicinal herbs for cognitive enhancement based on the text mining of Dongeuibogam and preliminary evaluation of its effects
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Transcriptional Signatures of Cognitive Impairment in Rat Exposed to Prenatal Stress
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BDNF rs6265 Polymorphism and Its Methylation in Patients with Stroke Undergoing Rehabilitation
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Authors: Cowansage, K., LeDoux, J., & Monfils, M.-H.
Affiliations: New York University (US)
ORCID: Cowansage, Kiriana
LeDoux, Joseph
Monfils, Marie-H.
Venue: Current Molecular Pharmacology
Publisher: Elsevier BV
Published: 2010-01-01
Volume: 3
Issue: 1
Pages: 12-29
ISSN: 1874-4672 (ISSN-L)
DOI: 10.2174/1874467211003010012
OpenAlex: W2158714604
Cited by: 372
References: 0
Citations by year: 2026: 6 · 2025: 11 · 2024: 8 · 2023: 18 · 2022: 16 · 2021: 24 · 2020: 22 · 2019: 27 · 2018: 26 · 2017: 30 · 2016: 27 · 2015: 35 · 2014: 23 · 2013: 36 · 2012: 38
FWCI: 12.65
Type: journal article
Language: en
Open access: closed
Locations: Current Molecular Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: brain-derived neurotrophic factor, neuroplasticity, synaptic plasticity, neurotrophins, amygdala, hippocampus, emotional memory, maternal deprivation, environmental enrichment, epigenetic regulation, post-translational regulation, therapeutic target
MeSH terms: RE1-Silencing Transcription Factor, Hippocampus, Humans, Learning, Memory, Neuronal Plasticity, Repressor Proteins, Signal Transduction, Brain-Derived Neurotrophic Factor, Epigenesis, Genetic, Methyl-CpG-Binding Protein 2

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Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity.

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