Bilateral intracerebroventricular injection of streptozotocin induces AD-like behavioral impairments and neuropathological features in mice: Involved with the fundamental role of neuroinflammation
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Objective To establish an Alzheimer's disease (AD) mouse model, investigate the behavioral performance changes and intracerebral molecular changes induced by bilateral intracerebroventricular injection of streptozotocin (STZ/I.C.V), and explore the potential pathogenesis of AD. Methods An AD mouse model was established by STZ/I.C.V. The behavioral performance was observed via the open field test (OFT), novel object recognition test (NOR), and tail suspension test (TST). The mRNA and protein expressions of interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) in the hippocampus were measured via qPCR and Western blot. The expression of β-amyloid 1-42 (Aβ 1-42 ), phosphorylated Tau protein (p-Tau (Ser396)), Tau5, β-site amyloid precursor protein (APP) cleaving enzyme (BACE), insulin receptor substrate 1 (IRS1), brain-derived neurotrophic factor (BDNF), Copine6, synaptotagmin-1 (Syt-1), synapsin-1, phosphoinositol 3 kinase (PI3K), serine/threonine kinase (Akt), phosphorylated serine/threonine kinase (p-Akt (Ser473)), triggering receptor expressed on myeloid cells-1/2 (TREM1/2) were detected using Western blot, and the expression of glial fibrillary acidic protein (GFAP), ionized calcium binding adapter molecule 1 (IBA1), Aβ 1-42 , p-Tau(Ser396), Syt-1, BDNF were measured via immunofluorescence staining. Results STZ/I.C.V induced AD-like neuropsychiatric behaviors in mice, as indicated by the impairment of learning and memory, together with the reduced…
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Both T2DM and AD mouse models show a neuroinflammation-related imbalance of TREM1/2 expression in the hippocampus, closely related to impaired behavioral task performance.
“both T2DM and AD mice models showed a neuroinflammation-related imbalance of TREM1/2 expression in the hippocampus, with a close relation with the impaired performance in behavioral tasks (Fan et al., 2022).”
From AD-Like Neuropsychiatric Dysfunction in a Mice Model Induced by a Combination of High-Fat Diet and Intraperitoneal Injection of Streptozotocin (2024) · cites this paper as Fan et al., 2022
STZ induces behavioral impairments in rodents.
“the results of our previous studies suggested that STZ could induce behavioral impairments in rodents (Qi et al., 2021; Fan et al., 2022; X. Gao et al., 2023b).”
From AD-Like Neuropsychiatric Dysfunction in a Mice Model Induced by a Combination of High-Fat Diet and Intraperitoneal Injection of Streptozotocin (2024) · cites this paper as Fan et al., 2022
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Sun, H., Gao, X., Niu, J., Chen, P., He, S., Xu, S., & Ge, J. (2024) · eneuro · doi:10.1523/eneuro.0310-24.2024 · Cited by 12 · see citing works
Self-citation
- Authors
- Fan, M., Liu, S., Sun, H.-M., Ma, M.-D., Gao, Y.-J., Qi, C.-C., Xia, Q.-R., & Ge, J.-F.
- Affiliations
- Anhui Medical University (CN)
- Corresponding author
- Ge, Jin-Fang
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 153
- Pages
- 113375
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W4285005814
- Cited by
- 50
- References
- 10
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 12 · 2023: 7 · 2022: 2
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Key Technologies Research and Development Program (202004j07020001)
- National Natural Science Foundation of China (81870403, 81701327)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- mouse models of Alzheimer's disease, streptozotocin, intracerebroventricular administration, neuroinflammation, amyloid-beta, tau phosphorylation, BACE, TREM-1, TREM2, brain-derived neurotrophic factor, PI3K/Akt signaling, synaptotagmin-1, synapsin-1, hippocampus, learning and memory impairment, neurodegeneration
- MeSH terms
- Triggering Receptor Expressed on Myeloid Cells-1, Neuroinflammatory Diseases, Alzheimer Disease, Animals, Disease Models, Animal, Hippocampus, Membrane Glycoproteins, Receptors, Immunologic, RNA, Messenger, Serine, Streptozocin, Tumor Necrosis Factor-alpha, Interleukin-6, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Synapsins, Brain-Derived Neurotrophic Factor, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Mice
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