Isolation of Extracellular Vesicles Derived from Mesenchymal Stromal Cells by Ultracentrifugation

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099 · see citing works

Exosomes: composition, biogenesis and function

Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,355 · see citing works

Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles

Lötvall, J. O., Hill, A. F., Hochberg, F. H., Buzás, E. I., Vizio, D. D., Gardiner, C., Gho, Y. S., Kurochkin, I. V., Mathivanan, S., Quesenberry, P. J., et al. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.26913 · Cited by 2,710 · see citing works

Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo

Bartholomew, A. M., Sturgeon, C., Siatskas, M., Ferrer, K., McIntosh, K. R., Patil, S., Hardy, W., Devine, S. M., Ucker, D. S., Deans, R., et al. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(01)00769-x · Cited by 2,296 · see citing works

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

Mittelbrunn, M., Gutiérrez‐Vázquez, C., Villarroya‐Beltri, C., González, S., Sánchez‐Cabo, F., González, M. A., Bernad, A., & Sánchez‐Madrid, F. (2011) · Nature Communications · doi:10.1038/ncomms1285 · Cited by 1,768 · see citing works

Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication

Ratajczak, J., Wysoczynski, M., Hayek, F., Janowska-Wieczorek, A., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404296 · Cited by 1,340 · see citing works

Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury

Bruno, S., Grange, C., Deregibus, M. C., Calogero, R., Saviozzi, S., Collino, F., Morando, L., Busca, A., Falda, M., Bussolati, B., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008070798 · Cited by 1,332 · see citing works

Isolation of Extracellular Vesicles: General Methodologies and Latest Trends

Konoshenko, M. Y., Lekchnov, E. A., Vlassov, A. V., & Laktionov, P. P. (2018) · BioMed Research International · doi:10.1155/2018/8545347 · Cited by 1,257 · see citing works

Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms.

Tögel, F., Hu, Z.-M., Weiss, K., Isaac, J., Lange, C., & Westenfelder, C. (2005) · AJP - Renal Physiology · doi:10.1152/ajprenal.00007.2005 · Cited by 1,196 · see citing works

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

Balaj, L., Lessard, R., Dai, L., Cho, Y., Pomeroy, S. L., Breakefield, X. O., & Skog, J. (2011) · Nature Communications · doi:10.1038/ncomms1180 · Cited by 1,185 · see citing works

Exosomes/microvesicles as a mechanism of cell-to-cell communication

Camussi, G., Deregibus, M. C., Bruno, S., Cantaluppi, V., & Biancone, L. (2010) · Kidney International · doi:10.1038/ki.2010.278 · Cited by 1,179 · see citing works

Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

Azmi, A. S., Bao, B., & Sarkar, F. H. (2013) · Cancer and Metastasis Reviews · doi:10.1007/s10555-013-9441-9 · Cited by 1,159 · see citing works

Exosomes: endosomal-derived vesicles shipping extracellular messages

Février, B., & Raposo, G. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.06.003 · Cited by 1,013 · see citing works

Current methods for the isolation of extracellular vesicles

Momen-Heravi, F., Balaj, L., Alian, S., Mantel, P., Halleck, A., Trachtenberg, A., Soria, C. E., Oquin, S., Bonebreak, C. M., Saraçoğlu, E., et al. (2013) · Biological chemistry · doi:10.1515/hsz-2013-0141 · Cited by 568 · see citing works

Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding.

Harding, C. V., Heuser, J., & Stahl, P. D. (1984) · PubMed · Cited by 415 · see citing works

Human liver stem cell‐derived microvesicles accelerate hepatic regeneration in hepatectomized rats

Herrera, M. B., Fonsato, V., Gatti, S., Deregibus, M. C., Sordi, A., Cantarella, D., Calogero, R., Bussolati, B., Tetta, C., & Camussi, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00860.x · Cited by 309 · see citing works

C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction

Guescini, M., Guidolin, D., Vallorani, L., Casadei, L., Gioacchini, A. M., Tibollo, P., Battistelli, M., Falcieri, E., Battistin, L., Agnati, L. F., et al. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.006 · Cited by 294 · cited 1× · see citing works

Mesenchymal Stem Cells Prevent Progressive Experimental Renal Failure but Maldifferentiate into Glomerular Adipocytes

Kunter, U., Rong, S., Boor, P., Eitner, F., Müller‐Newen, G., Djurić, Ž., van Roeyen, C. R. C., Konieczny, A., Ostendorf, T., Villa, L., et al. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007010044 · Cited by 275 · see citing works

Safety of Mesenchymal Stem Cells for Clinical Application

Wang, Y., Han, Z., Song, Y., & Han, Z. (2012) · Stem Cells International · doi:10.1155/2012/652034 · Cited by 206 · see citing works

Paracrine/endocrine mechanism of stem cells on kidney repair: role of microvesicle-mediated transfer of genetic information

Camussi, G., Deregibus, M. C., & Tetta, C. (2009) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e328332fb6f · Cited by 168 · see citing works

Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death

Stone, M. L., Zhao, Y., Smith, J. R., Weiss, M. L., Kron, I. L., Laubach, V. E., & Sharma, A. K. (2017) · Respiratory Research · doi:10.1186/s12931-017-0704-9 · Cited by 134 · see citing works

Perfusion of isolated rat kidney with Mesenchymal Stromal Cells/Extracellular Vesicles prevents ischaemic injury

Gregorini, M., Corradetti, V., Pattonieri, E. F., Rocca, C., Milanesi, S., Peloso, A., Canevari, S., Cecco, L. D., Dugo, M., Avanzini, M. A., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13249 · Cited by 116 · see citing works

Mesenchymal Stem Cells Improve Medullary Inflammation and Fibrosis after Revascularization of Swine Atherosclerotic Renal Artery Stenosis

Ebrahimi, B., Eirin, A., Li, Z., Zhu, X.-Y., Zhang, X., Lerman, A., Textor, S. C., & Lerman, L. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067474 · Cited by 106 · see citing works

Extracellular Vesicles from Human Liver Stem Cells Reduce Injury in an Ex Vivo Normothermic Hypoxic Rat Liver Perfusion Model

Rigo, F., Stefano, N. D., Navarro‐Tableros, V., David, E., Rizza, G., Catalano, G., Gilbo, N., Maione, F., Gonella, F., Roggio, D., et al. (2018) · Transplantation · doi:10.1097/tp.0000000000002123 · Cited by 91 · see citing works

T cells from autoimmune patients display reduced sensitivity to immunoregulation by mesenchymal stem cells: Role of IL-2

Ben-Ami, E., Miller, A., & Berrih‐Aknin, S. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.09.007 · Cited by 40 · see citing works

Extracellular Vesicles from MSC Modulate the Immune Response to Renal Allografts in a MHC Disparate Rat Model

Koch, M., Lemke, A., & Lange, C. (2015) · Stem Cells International · doi:10.1155/2015/486141 · Cited by 39 · see citing works

Potential Applications of Extracellular Vesicles in Solid Organ Transplantation

Grange, C., Bellucci, L., Bussolati, B., & Ranghino, A. (2020) · Cells · doi:10.3390/cells9020369 · Cited by 33 · see citing works

Impact of Mesenchymal Stromal Cells and Their Extracellular Vesicles in a Rat Model of Kidney Rejection

Ramírez-Bajo, M. J., Rovira, J., Lazo-Rodríguez, M., Bañón-Maneus, E., Tubita, V., Moya‐Rull, D., Hierro-Garcia, N., Ventura‐Aguiar, P., Oppenheimer, F., Campistol, J. M., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00010 · Cited by 27 · see citing works

Nephroprotective Potential of Mesenchymal Stromal Cells and Their Extracellular Vesicles in a Murine Model of Chronic Cyclosporine Nephrotoxicity

Ramírez-Bajo, M. J., Martín-Ramírez, J., Bruno, S., Pasquino, C., Bañón-Maneus, E., Rovira, J., Moya‐Rull, D., Lazo-Rodríguez, M., Campistol, J. M., Camussi, G., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00296 · Cited by 21 · see citing works

Surface plasmon resonance biosensor for exosome detection based on reformative tyramine signal amplification activated by molecular aptamer beacon

Chen, W., Li, Z., Cheng, W., Wu, T., Li, J., Li, X., Liu, L., Bai, H., Ding, S., Yu, X., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01210-x · Cited by 106 · see citing works

Advances in mesenchymal stem/stromal cell-based therapy and their extracellular vesicles for skin wound healing

Saadh, M. J., Ramírez-Coronel, A. A., Saini, R. S., Arias-Gonzáles, J. L., Amin, A. H., Gavilán, J. C. O., & Sârbu, I. (2023) · Human Cell · doi:10.1007/s13577-023-00904-8 · Cited by 30 · see citing works

Mesenchymal stem cell-derived extracellular vesicles for human diseases

Zhang, X., Che, X., Zhang, S., Wang, R., Li, M., Jin, Y., Wang, T., & Song, Y. (2024) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2023.47 · Cited by 27 · see citing works

Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients

Baron, M., Drohat, P., Crawford, B., Hornicek, F. J., Best, T. M., & Kouroupis, D. (2023) · Bioengineering · doi:10.3390/bioengineering10101187 · Cited by 19 · see citing works

Simultaneous Detection of Two Extracellular Vesicle Subpopulations in Saliva Assisting Tumor T Staging of Oral Squamous Cell Carcinoma

Feng, J., Xiao, B.-L., Zhang, L., Zhang, Y., Tang, M., Xu, C.-M., Chen, G., & Zhang, Z. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c00940 · Cited by 15 · see citing works

Extracellular vesicles from mesenchymal stem/stromal cells as emerging tools in wound healing: mechanisms and therapeutic potential

Uminska, W., Fekner, Z., Kasiński, D., & Pokrywczyńska, M. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04813-5 · Cited by 12 · see citing works

Extracellular vesicles derived from mesenchymal stem cells ameliorate cognitive impairment caused by neuroinflammation in young but not aged mice

Lykhmus, O., Kalashnyk, O., Skok, M. V., Deryabina, О. G., Toporova, O. K., Pokholenko, I., Gorbatiuk, O. B., & Арнольдович, К. В. (2024) · Exploration of neuroscience · doi:10.37349/en.2024.00045 · Cited by 2 · see citing works

Surface Plasmon Resonance Biosensor for Sensitive Detection of HER2-positive Exosomes Based on Reformative Tyramine Signal Amplification Activated by Molecular Aptamer Beacon ConversionPreprint

Chen, W., Li, Z., Cheng, W., Wu, T., Li, J. X., Li, X., Liu, L., Bai, H., Ding, S., Li, X., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-985834/v1

Additional file 1 of Surface plasmon resonance biosensor for exosome detection based on reformative tyramine signal amplification activated by molecular aptamer beacon

Chen, W., Li, Z., Cheng, W., Wu, T., Li, J., Li, X., Liu, L., Bai, H., Ding, S., Li, X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17598405

From Conditioned Media to Therapeutics: Isolation and Characterization of Mesenchymal Stem Cell–Derived Extracellular Vesicles

Mathew, C. K., Sharma, Y., & Mohanty, S. (2026) · Neuromethods · doi:10.1007/978-1-0716-4905-3_8

Isolation and characterization of extracellular vesicles from different types of mesenchymal stromal/stem cells for future translation research

Gordiienko, I. M., Shamshur, M., Petryk, N., & Zlatska, A. V. (2024) · Biopolymers and Cell · doi:10.7124/bc.000acd

Protocol for isolating leukemia-derived extracellular vesicles from the spleen of preclinical models of leukemia using ultracentrifugation

Gargiulo, E., Morande, P. E., Jeyakumar, M., Rospape, L., Paggetti, J., & Moussay, E. (2024) · STAR Protocols · doi:10.1016/j.xpro.2024.103244 · Cited by 1 · see citing works

Exosomes/EVs: IMPACT OF MESENCHYMAL STROMAL/STEM CELL ISOLATION STRATEGIES ON FUNCTIONAL ACTIVITIES OF THEIR EXTRACELLULAR VESICLES

Stambouli, O., Dittrich, R., Bauer, F. N., Tertel, T., Horn, P., & Giebel, B. (2022) · Cytotherapy · doi:10.1016/s1465-3249(22)00273-0

Characterization of small extracellular vesicles from human bone marrow mesenchymal stromal cells cultured in an extracellular vesicle-free medium

Wagey, R., Sampaio, A. V., Christie, J., Jonker, I., Kassam, A., Eaves, A. C., Szilvassy, S. J., & Louis, S. A. (2021) · Cytotherapy · doi:10.1016/s1465324921004631

Protocol for the isolation and characterization of extracellular vesicles from human mesenchymal stromal cells

Collins, A., Liddle, J., Balsbaugh, J. L., Walker, J., Wanczyk, H., Finck, C. M., & Saneh, H. (2026) · STAR Protocols · doi:10.1016/j.xpro.2026.104745