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Cited by 95Liver physiology and pathologyLiver Disease Diagnosis and TreatmentOrgan Transplantation Techniques and Outcomes

Hepatic stellate cells: Three-dimensional structure, localization, heterogeneity and development

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WAKE, Kenjiro·2006·Proceedings of the Japan Academy, Series B
DOI 10.2183/pjab.82.155PMC PMC4323047
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Abstract

Hepatic stellate cells (HSCs) are vitamin-A storing collagen-producing cells in hepatic lobules. The three-dimensional structure of HSCs has been demonstrated with the Golgi method, the maceration method for scanning electron microscopy, and confocal laser scanning microscopy. Many thorn-like microprojections or spines extend from the subendothelial processes and make contacts with hepatocytes. One HSC entwines two or more sinusoids and about 20-40 hepatocytes to create a cellular unit, 'the stellate cell unit' or 'stellon'. The Space of Disse is defined as the space between stellate cell-endothelial cell complex and hepatocytes. Intralobular heterogeneity of HSCs is assessed. HSCs develop from mesenchymal cells in the septum transversum. The developmental process of HSCs is reproduced partly in culture. In the lamprey abundant vitamin A is stored not only in HSCs, but in the fibroblast-like cells in the various other splanchnic organs. In vertebrates, the existence of both conventional fibroblast system in somatic tissues and vitamin A-storing cell system in splanchnic organs is suggested.

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  1. Bourne, G. H., and Danielli, J. F.). Vol. 66, Academic Press, New York, pp. 303-353.
  2. Berk, P. D.). Vol. 21, No. 3, Thieme, New York, pp. 307-459.
  3. Wisse, E., Knook, D. L., and Decker, K.). Vol. 2, Kupffer Cell Foundation, Rijswijk, The Netherlands, pp. 449-450.
  4. Motta, P. M.). Alan R. Liss. Inc., pp. 257-262.
  5. Koike, H., Kidokoro, Y., Takahashi, K., and Kanaseki, T.). Japan Sci. Soc. Press, Tokyo, pp. 293-312.
  6. Wisse, E., Knook, D. L., and Wake, K.). Vol. 5, Kupffer Cell Foundation, Leiden, The Netherlands, pp. 241-246.
  7. Friedman, S. L.) Seminars in Liver Disease 21, pp. 337-349.
  8. Vidal-Vanaclocha, F.). Springer, New York, R. G. Landes, Austin, pp. 57-67.
  9. Knook, D. L., and Wisse, E. ). Elsevier, Amsterdam, pp. 1-12.
  10. Knook, D. L., and Wisse, E.). Vol. 4, Kupffer Cell Foundation, Leiden, The Netherlands, pp. 231-234.
  11. Santisteban, A., Olaso, E., Bidaurrazaga, J., Rosenbaum, J., and Vidal-Vanachlocha, F. (1999) In Cells of the Hepatic Sinusoid (eds. Wisse, E., Knook, D. L., de Zanger, R., and Fraser, R.). Vol. 7, Kupffer Cell Foundation, Leiden, The Netherlands, pp. 41-42.
  12. Wake, K., Motomatsu, K., and Ekataksin, W. (1991) In Cells of the Hepatic Sinusoid (eds. Wisse, E., Knook, D. L., and McCuskey, R. S.). Vol. 3, Leiden, The Netherlands, pp. 269-275.
  13. Wake, K., and Senoo, H. (1986) In Cells of the Hepatic Sinusoid (eds. Kirn, A., Knook, D. L., and Wisse, E.). Vol. 1, Kupffer Cell Foundation, Rijswijk, The Netherlands, pp. 215-220.
  14. Surrenti, C., Casini, A., Milani, S., and Pinzani, M.). Kluwer Academic Publishers, Dordrecht, pp. 1-10. (Received March 29, 2006; accepted April 12, 2006)

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Authors
WAKE, K.
Affiliations
Tokyo Medical and Dental University (JP)
Corresponding author
WAKE, Kenjiro
Venue
Proceedings of the Japan Academy, Series B
Publisher
Japan Academy
Published
2006
Volume
82
Issue
4
Pages
155-164
ISSN
  • 0386-2208 (ISSN-L)
  • 1349-2896
DOI
10.2183/pjab.82.155
PMC
PMC4323047
OpenAlex
W2020223171
Cited by
95
References
52
Citations by year
2026: 9 · 2025: 17 · 2024: 7 · 2023: 7 · 2022: 21 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 3 · 2015: 3 · 2012: 2
FWCI
0.18
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the Japan Academy Series B (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords
hepatic stellate cells, three-dimensional cell structure, space of Disse, HSC heterogeneity, mesenchymal origin, vitamin A storage, collagen synthesis, lamprey, hepatic lobule

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