Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer
Open accessAbstract
BACKGROUND/AIM: Amplification of chromosome 7p (Ch.7p) is common in colorectal cancer (CRC). The aim of this study was to identify potential driver genes on Ch.7p that are overexpressed due to DNA copy number amplification and determine their clinical significance in CRC. MATERIALS AND METHODS: We identified phosphoserine phosphatase (PSPH) as a potential driver gene using a CRC dataset from The Cancer Genome Atlas (TCGA) using a bioinformatics approach. The expression of PSPH in 124 primary CRCs was examined by quantitative reverse transcription polymerase chain reaction (PCR) and immunohistochemistry. The biological effect of PSPH expression was explored by Gene Set Enrichment Analysis (GSEA) using the TCGA dataset. RESULTS: PSPH was overexpressed in tumor tissues and PSPH positively correlated with depth of invasion and distant metastasis. On multivariate analysis, high PSPH expression was an independent poor prognostic factor. These results were supported by GSEA. CONCLUSION: PSPH could be a novel prognostic biomarker with malignant potential on Ch.7p in CRC.
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PSPH is a promising prognostic biomarker in different cancers such as advanced colorectal cancer, thyroid cancer, and melanoma.
“PSPH is associated with the development of various cancers and is a promising prognostic biomarker in different cancers such as advanced colorectal cancer [17], thyroid cancer [18] and melanoma [19].”
From Phosphoserine phosphatase as a prognostic biomarker in patients with gastric cancer and its potential association with immune cells (2022) · cites this paper as [17]
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- Authors
- SATO, K., MASUDA, T., HU, Q., TOBO, T., KIDOGAMI, S., OGAWA, Y., SAITO, T., NAMBARA, S., KOMATSU, H., HIRATA, H., SAKIMURA, S., UCHI, R., HAYASHI, N., IGUCHI, T., EGUCHI, H., ITO, S., NAKAGAWA, T., & MIMORI, K.
- Affiliations
- Kyushu University (JP)
- Kyushu University Beppu Hospital (JP)
- ORCID
- Venue
- Anticancer Research
- Published
- 2017-05-07
- Volume
- 37
- Issue
- 5
- Pages
- 2365-2371
- ISSN
- 0250-7005 (ISSN-L)
- 1791-7530
- OpenAlex
- W2613203675
- Cited by
- 46
- References
- 7
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 1
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Anticancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Tokyo
- Japan Society for the Promotion of Science (16K10543, 16K19107, 16K10397, 16K19197, 16K07177, 15K10170)
- Institute of Medical Science, University of Tokyo
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- phosphoserine phosphatase, colorectal cancer, prognostic factors, driver genes, gene overexpression, depth of invasion, distant metastasis, poor prognosis
- MeSH terms
- Aged, Chromosomes, Human, Pair 7, Colon, Female, Humans, Male, Phosphoric Monoester Hydrolases, Prognosis, RNA, Messenger, Biomarkers, Tumor, Colorectal Neoplasms, Gene Expression Regulation, Neoplastic, DNA Copy Number Variations
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