Advances in Nanocarriers for Drug Delivery in Dental Therapies
Open accessAbstract
Dental caries are one of the major causes of oral degeneration diseases. In order to treat dental-related diseases, it is often challenging and expensive. Recent literature has reported many advances in designing delivery systems utilizing polymers and novel biomaterials. Polymers play an important role in designing many nanoformulations like liposomes, polymeric micelles, polymeric nanoparticles, carbon-based nanoparticles, nano-hydroxyapatite, iron oxide, zirconia, silica, and silver nanoparticles were used to treat oral complications of the oral cavity including dental caries, periodontal disease, and oral cancer. The present review focus on the importance of novel biodegradable polymers like poly (D, L-Lactide acid), PLLA (poly-L-lactide), PDLA (poly-D- lactide), PLGA that is poly (D, L Lactide-co-glycolide), cellulose acetate phthalate, and Chitosan, etc used to design site-specific delivery and controlled drug delivery to treat dental diseases. Moreover, research development in this area will raise opportunities for the dentist, researchers, and pharmaceutical scientists to fabricate an ideal drug delivery system.
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Through its intrinsic redox-regulating capability, PDA modulates the local oxidative microenvironment, exerting anti-inflammatory and tissue-protective effects.
“Through its intrinsic redox-regulating capability, PDA is able to modulate the local oxidative microenvironment, thereby exerting anti-inflammatory and tissue-protective effects.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [15]
The Abstract (page not provided) reports that a polydopamine nanoformulation removes reactive oxygen species in oxidative stress–induced periodontitis and shows anti-inflammatory effects. It does not report a tissue-protective effect of that formulation, so that part of the claim is unsupported. (LLM, conf=0.84)
Experimental — accuracy not yet measuredPDA-based intelligent drug delivery systems have emerged as promising strategies to overcome the limitations of conventional periodontitis therapy and provide more effective regulation of periodontal inflammation.
“In this context, PDA-based intelligent drug delivery systems have emerged as promising strategies to overcome these limitations and provide more effective regulation of periodontal inflammation.15,71”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [15]
The passage labeled Abstract reports an injectable poly(dopamine) nanoformulation for periodontitis and says in-vitro and in-vivo evaluations found anti-inflammatory and reactive-oxygen-species-removing effects. It does not describe that PDA formulation as an intelligent drug-delivery system or show that it overcomes limitations of conventional periodontitis therapy. The Conclusion discusses nanocarriers as promising dental therapies more generally. (LLM, conf=0.84)
Experimental — accuracy not yet measured
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How Will Nanomedicine Revolutionize Future Dentistry and Periodontal Therapy?
D’Amico, E., Aceto, G. M., Petrini, M., Cinquini, C., D’Ercole, S., Iezzi, G., & Pierfelice, T. V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020592 · Cited by 7 · see citing works
Yang, Z., Song, W., Lv, L., Zhai, S., Liu, Y., Cui, H., Li, X., Gao, F., & Chu, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s611922
Soi, S., Sharma, M., Sushant, S., Mrinalini, M., Saini, S. K., Dave, A., & Sharma, D. (2026) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_2426_25
- Authors
- Patel, B., Kamineni, Y., Gorityala, S., & Bindu, M. H.
- Affiliations
- Covance (United States) (US)
- ORCID
- Gorityala, Shashank
- Venue
- Recent Progress in Materials
- Publisher
- LIDSEN Publishing Inc
- Published
- 2021-09-28
- Volume
- 03
- Issue
- 03
- Pages
- 1-18
- ISSN
- 2689-5846 (ISSN-L)
- OpenAlex
- W3203243580
- Cited by
- 2
- References
- 54
- Citations by year
- 2026: 1 · 2025: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Recent Progress in Materials (publishedVersion, cc-by)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Dentistry › Orthodontics › Dental materials and restorations
- Keywords
- nanocarriers, drug delivery, dental therapeutics, dental caries, periodontal disease, oral cancer, biodegradable polymers, polymeric nanoparticles, liposomes, polymeric micelles, hydroxyapatite nanoparticles, carbon nanoparticles, iron oxide nanoparticles, zirconia nanoparticles, silica nanoparticles, silver nanoparticles, chitosan, PLGA, controlled drug delivery, local drug delivery
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