Telehealth for the Longitudinal Management of Chronic Conditions: Systematic Review
Open accessAbstract
Background: Extensive literature support telehealth as a supplement or adjunct to in-person care for the management of chronic conditions such as congestive heart failure (CHF) and type 2 diabetes mellitus (T2DM). Evidence is needed to support the use of telehealth as an equivalent and equitable replacement for in-person care and to assess potential adverse effects. Objective: We conducted a systematic review to address the following question: among adults, what is the effect of synchronous telehealth (real-time response among individuals via phone or phone and video) compared with in-person care (or compared with phone, if synchronous video care) for chronic management of CHF, chronic obstructive pulmonary disease, and T2DM on key disease-specific clinical outcomes and health care use? Methods: We followed systematic review methodologies and searched two databases (MEDLINE and Embase). We included randomized or quasi-experimental studies that evaluated the effect of synchronously delivered telehealth for relevant chronic conditions that occurred over ≥2 encounters and in which some or all in-person care was supplanted by care delivered via phone or video. We assessed the bias using the Cochrane Effective Practice and Organization of Care risk of bias (ROB) tool and the certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation. We described the findings narratively and did not conduct meta-analysis owing to the small number of studies and the conceptual heterogeneity of the identified interventions. Results: We identified 8662 studies, and 129 (1.49%) were reviewed at the full-text stage. In total, 3.9% (5/129) of the articles were retained for data extraction, all of which (5/5, 100%) were randomized controlled trials. The CHF study (1/5, 20%) was found to have high ROB and randomized patients (n=210) to receive quarterly automated asynchronous web-based review and follow-up of telemetry data versus synchronous personal follow-up (in-person vs phone-based) for 1 year. A 3-way comparison across study arms found no significant differences in clinical outcomes. Overall, 80% (4/5) of the studies (n=466) evaluated synchronous care for patients with T2DM (ROB was judged to be low for 2, 50% of studies and high for 2, 50% of studies). In total, 20% (1/5) of the studies were adequately powered to assess the difference in glycosylated hemoglobin level between groups; however, no significant difference was found. Intervention design varied greatly from remote monitoring of blood glucose combined with video versus in-person visits to an endocrinology clinic to a brief, 3-week remote intervention to stabilize uncontrolled diabetes. No articles were identified for chronic obstructive pulmonary disease. Conclusions: This review found few studies with a variety of designs and interventions that used telehealth as a replacement for in-person care. Future research should consider including observational studies and studies on additional highly prevalent chronic diseases.
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A systematic review of longitudinal management of chronic conditions by telehealth interventions reported no difference between asynchronous and in-person (synchronous) reviews of patient data.
“A systematic review of longitudinal management of chronic conditions by telehealth interventions [8] reported no difference between asynchronous and in-person (synchronous) reviews of patient data.”
From Digital Interventions for Self-Management of Type 2 Diabetes Mellitus: Systematic Literature Review and Meta-Analysis (2024) · cites this paper as [8]
The Abstract Results and the CHF findings in the Results section report no significant differences in measured clinical outcomes between asynchronous telemetry review and personal follow-up, including in-person visits. This finding comes from one high-risk-of-bias heart-failure study; it does not establish a general absence of differences between asynchronous and in-person reviews of patient data across chronic conditions. (LLM, conf=0.88)
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Mezei, F., Tsiasiotis, E., Basile, M., Sciomenta, I., Calosci, E. M., Antonini, D., Lukacs, A., Bidino, R. D., Cicchetti, A., & Sacchini, D. (2025) · Journal of Market Access & Health Policy · doi:10.3390/jmahp13030046 · Cited by 4 · see citing works
Hofner, M., Hurnaus, P., DiStefano, D., Philip, S., Kim, S., Shaw, J. L. V., & Waring, A. C. (2024) · JMIR Diabetes · doi:10.2196/53835 · Cited by 4 · see citing works
“However, the effectiveness of telehealth for chronic conditions remains unconfirmed, and the various telehealth solutions studied are heterogeneous, with some providing remote coaching only and others providing synchronous video visits with a prescribing provider [15-17].”
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Cardiovascular disease risk management during COVID-19: in-person vs virtual visits
Gold, R. B. (2024) · The American Journal of Managed Care · doi:10.37765/ajmc.2024.89489 · Cited by 4 · see citing works
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“While access is necessary, meaningful and consistent usage is what enables older adults to gain tangible benefits—such as improved health monitoring (Lewinski et al., 2022), social connectivity (Chung et al., 2024), and service access (Yu et al., 2025).”
Leveraging telemedicine to improve MNCH uptake in Kenya: a community-based hybrid model
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Feasibility and Acceptability of Community-Based Telehealth to Prevent Long-Term Care Readmission
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“8,9 This observation is consistent with other research demonstrating that telehealth is underutilized in rural Medicaid populations.”
Zhou, X., Hu, D., Xiong, H., Zhou, H., Xu, H., & Tang, H. (2026) · Digital Health · doi:10.1177/20552076261433666 · Cited by 2 · see citing works
“Despite a growing body of literature on chronic disease management and telemedicine, 9 a considerable gap remains in bibliometric analyses that systematically investigate the role of telemedicine in home-based self-monitoring.”
Jones, H. T., Lynch, L., Barber, T., Rattue, M., Waters, L. J., Asboe, D., Walker, A., & Williams, I. G. (2025) · HIV Medicine · doi:10.1111/hiv.70041 · Cited by 2 · see citing works
“This work reports the positive impact virtual clinics can have for LTCM as they may help address the inequality people living in rural areas face for both HIV care and LTCM [24, 59, 86].”
Liu, W., Li, Y., Gao, S., Wang, X., & Zhang, F. (2025) · Medicine · doi:10.1097/md.0000000000042156 · Cited by 1 · see citing works
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“36,37 Recent evidence confirms that digital tools and hybrid models are being incorporated into chronic disease management, offering opportunities to enhance accessibility, reduce logistical burden and support longitudinal engagement.”
Association Between Telemedicine Adoption and Physician Job Satisfaction: Cross-Sectional Study
Zhai, X., Zhou, Z., Wang, Z., Liu, G., & Coyte, P. C. (2026) · Journal of Medical Internet Research · doi:10.2196/82285 · Cited by 1 · see citing works
“Telemedicine has become increasingly integrated into diverse clinical contexts, including primary care [5], chronic disease management [6], mental health services [7,8], and specialist consultations [9].”
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Tele-oncology Implementation Logic Model: Results of an Instrumental Study (Preprint)Preprint
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Self-citationExploring Telemedicine: The Perceptions and Utilization among Patients
Hajj, R., & Hanoun, J. (2024) · Biomedical engineering · doi:10.5772/intechopen.1004781
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Impacto de la telemedicina versus consultas presenciales en la gestión de diabetes e hipertensión
Medina, H. S. A., & Mendoza, G. S. B. (2025) · LATAM Revista Latinoamericana de Ciencias Sociales y Humanidades · doi:10.56712/latam.v6i1.3554
Akter, M., Akter, S., Hossain, M. I., Akter, N., Akter, S., Koly, A., Mahmud, S., Kabir, H., & Hasan, M. K. (2025) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000003201
“Like this, Allison et al (2022) discussed in their systematic review that patients with poor health status were more likely to demonstrate strong telehealth knowledge, supporting the findings of this study [ 29 ] .”
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Mabire, C., Panchaud, S., Wey, J., & Wicht, J. (2025) · Frontiers in Health Services · doi:10.3389/frhs.2025.1566997
“Furthermore, the integration of technology within home care, such as telehealth and remote monitoring, can further enhance Person-centered practice by facilitating continuous communication, support, and proactive care management (17).”
Cressman, S., Stewart, K., Scheuermeyer, F. X., Hedden, L., Duncan, R., Riches, L., Abu‐Laban, R. B., Raff, D., Assali, J., Lauscher, H. N., et al. (2025) · npj Digital Medicine · doi:10.1038/s41746-025-02060-9
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Walklin, C., Young, H. M. L., Asghari, E., Bhandari, S., Billany, R. E., Bishop, N., Bramham, K., Briggs, J., Burton, J. O., Campbell, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22735614
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The Future of Headache Disorders through AI Tools
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Haq, I. U., Sirica, D., Wheelock, V., Benedict, R. H. B., Sarno, M., Tjaden, K., Ozelius, L. J., Firth, R. S., Napoli, E., Sweadner, K. J., et al. (2026) · medRxiv · doi:10.64898/2026.02.18.26345928
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“23 24 Positive perception and acceptance of telehealth have been reported among both adult patients 25 26 and clinical dietitians 27 28 across various disease management.”
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Uncertainty-aware personalized estimation of Parkinson’s disease severity from longitudinal speech
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“This assumption neglects the longitudinal structure of telemonitoring data, where repeated observations are collected from the same individual over time [20].”
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“…for the ageing population in rural areas. consequently, the Wscs must adequately support service use and safeguard opportunities to access traditional service provision when needed, especially as the suitability of digital services as a replacement for physical services remains unclear [46].”
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“Efficient call center operations are critical as they serve as the primary communication link between patients and health care providers, ensuring timely medical services and patient satisfaction [4].”
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School of Health and the Prevention of Chronic Diseases in Nursing Practice
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- Authors
- Lewinski, A. A., Walsh, C., Rushton, S., Soliman, D., Carlson, S. M., Luedke, M. W., Halpern, D. J., Crowley, M. J., Shaw, R. J., Sharpe, J. A., Alexopoulos, A.-S., Tabriz, A. A., Dietch, J. R., Uthappa, D. M., Hwang, S., Ball Ricks, K. A., Cantrell, S., Kosinski, A. S., Ear, B., Gordon, A. M., Gierisch, J. M., Williams Jr, J. W., & Goldstein, K. M.
- Affiliations
- Duke University (US)
- Duke Medical Center (US)
- Durham VA Health Care System (US)
- Moffitt Cancer Center (US)
- Oregon State University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Lewinski, Allison A
- ORCID
- Lewinski, Allison A
- Walsh, Conor
- Rushton, Sharron
- Soliman, Diana
- Carlson, Scott M
- Luedke, Matthew W
- Halpern, David J
- Crowley, Matthew J
- Shaw, Ryan J
- Sharpe, Jason A
- Alexopoulos, Anastasia-Stefania
- Tabriz, Amir Alishahi
- Dietch, Jessica R
- Uthappa, Diya M
- Hwang, Soohyun
- Ball Ricks, Katharine A
- Cantrell, Sarah
- Kosinski, Andrzej S
- Ear, Belinda
- Gordon, Adelaide M
- Gierisch, Jennifer M
- Williams Jr, John W
- Goldstein, Karen M
- Venue
- Journal of Medical Internet Research
- Publisher
- JMIR Publications Inc.
- Published
- 2022-08-26
- Volume
- 24
- Issue
- 8
- Pages
- e37100
- ISSN
- 1438-8871 (ISSN-L)
- PMC
- PMC9463619
- OpenAlex
- W4293125272
- Cited by
- 71
- References
- 39
- Citations by year
- 2026: 23 · 2025: 15 · 2024: 14 · 2023: 18 · 2022: 1
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of Medical Internet Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (CIN 13–410, ESP-09-010, 18-234)
- Office of Research and Development
- Health Services Research and Development (#18-234, CIN 13‐410)
- Quality Enhancement Research Initiative
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Telemedicine and Telehealth Implementation
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Social Sciences › Demography › Technology Use by Older Adults
- Keywords
- telemedicine, synchronous telehealth, chronic disease management, congestive heart failure, type 2 diabetes, chronic obstructive pulmonary disease, HbA1c, health care utilization, adverse effects, risk of bias, health equity, remote patient monitoring, telephone care, glycemic control, health care costs
- MeSH terms
- Adult, Chronic Disease, Diabetes Mellitus, Type 2, Heart Failure, Humans, Telemedicine, Pulmonary Disease, Chronic Obstructive, Text Messaging
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