Health care professionals’ and parents’ perspectives on the use of AI for pain monitoring in the neonatal intensive care unit: multisite qualitative study
Open accessPublished version of a preprint
Abstract
BACKGROUND: The use of artificial intelligence (AI) for pain assessment has the potential to address historical challenges in infant pain assessment. There is a dearth of information on the perceived benefits and barriers to the implementation of AI for neonatal pain monitoring in the neonatal intensive care unit (NICU) from the perspective of health care professionals (HCPs) and parents. This qualitative analysis provides novel data obtained from 2 large tertiary care hospitals in Canada and the United Kingdom. OBJECTIVE: The aim of the study is to explore the perspectives of HCPs and parents regarding the use of AI for pain assessment in the NICU. METHODS: In total, 20 HCPs and 20 parents of preterm infants were recruited and consented to participate from February 2020 to October 2022 in interviews asking about AI use for pain assessment in the NICU, potential benefits of the technology, and potential barriers to use. RESULTS: The 40 participants included 20 HCPs (17 women and 3 men) with an average of 19.4 (SD 10.69) years of experience in the NICU and 20 parents (mean age 34.4, SD 5.42 years) of preterm infants who were on average 43 (SD 30.34) days old. Six themes from the perspective of HCPs were identified: regular use of technology in the NICU, concerns with regard to AI integration, the potential to improve patient care, requirements for implementation, AI as a tool for pain assessment, and ethical considerations. Seven parent themes included the potential for improved care, increased parental distress, support for parents regarding AI, the impact on parent engagement, the importance of human care, requirements for integration, and the desire for choice in its use. A consistent theme was the importance of AI as a tool to inform clinical decision-making and not replace it. CONCLUSIONS: HCPs and parents expressed generally positive sentiments about the potential use of AI for pain assessment in the NICU, with HCPs highlighting important ethical considerations. This study identifies critical methodological and ethical perspectives from key stakeholders that should be noted by any team considering the creation and implementation of AI for pain monitoring in the NICU.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Racine et al. (42) assessed AI for pain monitoring in neonatal intensive care units (NICUs); the AI-assisted systems enhanced the accuracy and consistency of pain assessments, enabling more effective pain management strategies for preterm infants.
“Racine et al. (42) assessed AI for pain monitoring in neonatal intensive care units (NICUs). The AI-assisted systems enhanced the accuracy and consistency of pain assessments, enabling more effective pain management strategies for preterm infants.”
From Artificial intelligence in nursing: an integrative review of clinical and operational impacts (2025) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Using thematic analysis in psychology
Braun, V., & Clarke, V. (2006) · Qualitative Research in Psychology · doi:10.1191/1478088706qp063oa · Cited by 194,414 · see citing works
How Many Interviews Are Enough?: An Experiment with Data Saturation and Variability
Guest, G., Bunce, A., & Johnson, L. (2006) · Field Methods · doi:10.1177/1525822x05279903 · Cited by 20,808 · see citing works
Interrater reliability: The kappa statistic
McHugh, M. L. (2012) · Biochemia Medica · doi:10.11613/bm.2012.031 · Cited by 19,877 · see citing works
Standards for Reporting Qualitative Research: A Synthesis of Recommendations
O’Brien, B. C., Harris, I. B., Beckman, T. J., Reed, D. A., & Cook, D. A. (2014) · Academic Medicine · doi:10.1097/acm.0000000000000388 · Cited by 12,211 · see citing works
Blencowe, H., Cousens, S., Oestergaard, M. Z., Chou, D., Moller, A.-B., Narwal, R., Adler, A., Vera Garcia, C., Rohde, S., Say, L., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60820-4 · Cited by 4,568 · see citing works
An overview of clinical decision support systems: Benefits, risks, and strategies for success
Sutton, R. T., Pincock, D., Baumgart, D. C., Sadowski, D. C., Fedorak, R. N., & Kroeker, K. I. (2020) · npj Digital Medicine · doi:10.1038/s41746-020-0221-y · Cited by 3,019 · see citing works
Grounded theory research: A design framework for novice researchers
Chun Tie, Y., Birks, M., & Francis, K. (2019) · SAGE Open Medicine · doi:10.1177/2050312118822927 · Cited by 1,869 · cited 1× · see citing works
“Using a grounded theory approach [23], the goal of the qualitative interviews was to generate detailed knowledge about HCPs’ and parents’ understandings and perceptions of the use of AI in the NICU to assist with infant pain assessment and management.”
MethodCarman, K. L., Dardess, P., Maurer, M. E., Sofaer, S., Adams, K., Bechtel, C., & Sweeney, J. (2013) · Health Affairs · doi:10.1377/hlthaff.2012.1133 · Cited by 1,770 · see citing works
Ohuma, E. O., Moller, A., Bradley, E., Chakwera, S., Hussain‐Alkhateeb, L., Lewin, A., Okwaraji, Y. B., Mahanani, W. R., Johansson, E. W., Lavin, T., et al. (2023) · The Lancet · doi:10.1016/s0140-6736(23)00878-4 · Cited by 1,659 · see citing works
The FLACC: a behavioral scale for scoring postoperative pain in young children.
Merkel, S. I., Voepel‐Lewis, T., Shayevitz, J. R., & Malviya, S. V. (1997) · PubMed · Cited by 1,623 · see citing works
Coproduction of healthcare service
Batalden, M., Batalden, P., Margolis, P., Seid, M., Armstrong, G., Opipari-Arrigan, L., & Hartung, H. (2016) · BMJ Quality & Safety · doi:10.1136/bmjqs-2015-004315 · Cited by 1,078 · see citing works
Legal and Ethical Consideration in Artificial Intelligence in Healthcare: Who Takes Responsibility?
Naik, N., Hameed, B. M. Z., Shetty, D. K., Swain, D., Shah, M., Paul, R., Aggarwal, K., Ibrahim, S., Patil, V., Smriti, K., et al. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.862322 · Cited by 931 · see citing works
Artificial Intelligence and Human Trust in Healthcare: Focus on Clinicians
Asan, O., Bayrak, A. E., & Choudhury, A. (2020) · Journal of Medical Internet Research · doi:10.2196/15154 · Cited by 825 · see citing works
Can Adverse Neonatal Experiences Alter Brain Development and Subsequent Behavior?
Anand, K. J. S., & Scalzo, F. M. (2000) · Neonatology · doi:10.1159/000014197 · Cited by 616 · see citing works
Long-term consequences of pain in human neonates
GRUNAU, R. E., Holsti, L., & Peters, J. W. B. (2006) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2006.02.007 · Cited by 570 · see citing works
Validation of the Premature Infant Pain Profile in the Clinical Setting
Ballantyne, M., Stevens, B., McAllister, M. A., et al. (1999) · Clinical Journal of Pain · doi:10.1097/00002508-199912000-00006 · Cited by 272 · see citing works
Very preterm children show impairments across multiple neurodevelopmental domains by age 4 years
Woodward, L. J., Moor, S., Hood, K. M., CHAMPION, P. R., Foster‐Cohen, S., Inder, T. E., & Austin, N. C. (2009) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/adc.2008.146282 · Cited by 267 · see citing works
Fritsch, S. J., Blankenheim, A., Wahl, A., Hetfeld, P., Maaßen, O., Deffge, S., Kunze, J., Rossaint, R., Riedel, M., Marx, G., et al. (2022) · Digital Health · doi:10.1177/20552076221116772 · Cited by 255 · see citing works
Johnston, C. C., Barrington, K. J., Taddio, A., Carbajal, R., & Filion, F. (2010) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181fe14cf · Cited by 204 · see citing works
A Systematic Comparison of In-Person and Video-Based Online Interviewing
Lobe, B., Morgan, D. L., & Hoffman, K. A. (2022) · International Journal of Qualitative Methods · doi:10.1177/16094069221127068 · Cited by 168 · see citing works
Non-contact physiological monitoring of preterm infants in the Neonatal Intensive Care Unit
Villarroel, M., Chaichulee, S., Jorge, J., Davis, S., Green, G., Arteta, C., Zisserman, A., McCormick, K. P., Watkinson, P., & Tarassenko, L. (2019) · npj Digital Medicine · doi:10.1038/s41746-019-0199-5 · Cited by 155 · see citing works
Prgomet, M., Cardona, M., Nicholson, M., Lake, R., Long, J. C., Westbrook, J. I., Braithwaite, J., & Hillman, K. (2016) · International Journal for Quality in Health Care · doi:10.1093/intqhc/mzw062 · Cited by 110 · see citing works
Antes, A. L., Burrous, S., Sisk, B. A., Schuelke, M. J., Keune, J. D., & DuBois, J. M. (2021) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-021-01586-8 · Cited by 105 · see citing works
Multimodal spatio-temporal deep learning approach for neonatal postoperative pain assessment
Salekin, M. S., Zamzmi, G., Goldgof, D., Kasturi, R., Ho, T., & Sun, Y. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2020.104150 · Cited by 94 · cited 1× · see citing works
“…such as heart rate, respiratory rate, and oxygen saturation, of preterm infants have been developed, all of which provide physiological indications of pain or distress as well as systems that incorporate behavioral indicators (eg, face movements, body movements, and crying) to predict pain [17].”
BackgroundMcCradden, M. D., Sarker, T., & Paprica, P. A. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-039798 · Cited by 91 · see citing works
McAdams, R. M., Kaur, R. R., Sun, Y., Bindra, H., Cho, S. J., & Singh, H. (2022) · Journal of Perinatology · doi:10.1038/s41372-022-01392-8 · Cited by 89 · see citing works
Parents' Views About Infant Pain in Neonatal Intensive Care
Franck, L. S., Allen, A., Cox, S., et al. (2005) · Clinical Journal of Pain · doi:10.1097/00002508-200503000-00004 · Cited by 82 · see citing works
Sisk, B. A., Antes, A. L., Burrous, S., & DuBois, J. M. (2020) · Children · doi:10.3390/children7090145 · Cited by 71 · see citing works
The use of machine learning and artificial intelligence within pediatric critical care
Shah, N. A., Arshad, A., Mazer, M. B., Carroll, C. L., Shein, S. L., & Remy, K. E. (2022) · Pediatric Research · doi:10.1038/s41390-022-02380-6 · Cited by 64 · see citing works
Artificial intelligence, machine learning and the pediatric airway
Matava, C. T., Pankiv, E., Ahumada, L. M., et al. (2019) · Pediatric Anesthesia · doi:10.1111/pan.13792 · Cited by 54 · see citing works
Thai, K., Tsiandoulas, K., Stephenson, E. A., Menna‐Dack, D., Shaul, R. Z., Anderson, J. A., Shinewald, A., Ampofo, A., & McCradden, M. D. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.10659 · Cited by 54 · see citing works
Chronic Pain in Hospitalized Infants: Health Professionals' Perspectives
Riddell, R. P., Stevens, B., McKeever, P. D., Gibbins, S., Asztalos, L., Katz, J. D., Kohut, S. A., & El-Din, L. K. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.04.013 · Cited by 48 · see citing works
Self-citationInter-observer reliability of two pain scales for newborns
Bellieni, C. V., Cordelli, D. M., Caliani, C., et al. (2006) · Early Human Development · doi:10.1016/j.earlhumdev.2006.10.006 · Cited by 42 · see citing works
Artificial Intelligence to Improve Health Outcomes in the NICU and PICU: A Systematic Review
Adegboro, C. O., Choudhury, A., Asan, O., & Kelly, M. M. (2021) · Hospital Pediatrics · doi:10.1542/hpeds.2021-006094 · Cited by 41 · see citing works
Nash, D. M., Thorpe, C. F., Brown, J. B., Kueper, J. K., Rayner, J., Lizotte, D. J., Terry, A. L., & Zwarenstein, M. (2023) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2022.220177r2 · Cited by 40 · see citing works
Socio-economic risk factors for preterm birth in Norway 1999–2009
Oftedal, A.-M., Busterud, K., Irgens, L. M., Haug, K., & Rasmussen, S. (2016) · Scandinavian Journal of Public Health · doi:10.1177/1403494816653288 · Cited by 31 · see citing works
Building trust in artificial intelligence and new technologies in mental health
O’Dell, B., Stevens, K., Tomlinson, A., Singh, I., & Cipriani, A. (2022) · Evidence-Based Mental Health · doi:10.1136/ebmental-2022-300489 · Cited by 20 · see citing works
The Role of Infant Pain Behaviour in Predicting Parent Pain Ratings
Riddell, R. P., Flora, D. B., Stevens, S. A., et al. (2014) · Pain Research and Management · doi:10.1155/2014/934831 · Cited by 19 · see citing works
Self-citationCheng, D., Liu, D., Philpotts, L. L., Turner, D. P., Houle, T. T., Chen, L. L., Zhang, M., Yang, J., Zhang, W., & Deng, H. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-030482 · Cited by 15 · see citing works
Out of the mouth of babes: a lot about pain has nothing to do with pain.
Riddell, R. P. P., Jasim, S., & Hamwi, L. (2022) · Pain · doi:10.1097/j.pain.0000000000002761 · Cited by 11 · see citing works
Self-citationHuartson, K., Hill, T. R., Killam, T., Kelly, M. A., & Racine, N. M. (2022) · International Journal of Child and Adolescent Resilience · doi:10.54488/ijcar.2022.313 · Cited by 3 · see citing works
Self-citationArtificial Intelligence for NICU Pain Assessment: Ethical, Legal and Social ImplicationsPreprint
Stedman, I., Racine, N. M., Wang, X., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4336962 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Artificial intelligence in nursing: an integrative review of clinical and operational impacts
Hassanein, S., El Arab, R. A., Abdrbo, A., Abu-Mahfouz, M. S., Gaballah, M. K. F., Seweid, M. M., Almari, M., & Alzghoul, H. (2025) · Frontiers in Digital Health · doi:10.3389/fdgth.2025.1552372 · Cited by 134 · see citing works
- Authors
- Racine, N., Chow, C., Hamwi, L., Bucsea, O., Cheng, C., Du, H., Fabrizi, L., Jasim, S., Johannsson, L., Jones, L., Laudiano-Dray, M. P., Meek, J., Mistry, N., Shah, V., Stedman, I., Wang, X., & Riddell, R. P.
- Affiliations
- University of Ottawa (CA)
- York University (CA)
- Mount Sinai Hospital (CA)
- University College London (GB)
- University College Hospital (GB)
- Corresponding author
- Racine, Nicole
- ORCID
- Venue
- JMIR AI
- Publisher
- JMIR Publications Inc.
- Published
- 2024-02-09
- Volume
- 3
- Pages
- e51535
- ISSN
- 2817-1705 (ISSN-L)
- PMC
- PMC11041412
- OpenAlex
- W4389858138
- Cited by
- 19
- References
- 42
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 2
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- JMIR AI (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion, cc-by)
- Funders
- University of Ottawa
- Canadian Institutes of Health Research
- Medical Research Council (MR/S003207/1)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Ethics and Legal Issues in Pediatric Healthcare
- Keywords
- artificial intelligence, neonatal pain assessment, neonatal intensive care unit, preterm infants, healthcare professionals' perspectives, parents' perspectives, implementation barriers, ethical considerations, clinical decision-making, parental distress, parental involvement, human care
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review