The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Biphasic Dose Response in Low Level Light Therapy
Open accessAbstract
The use of low levels of visible or near infrared light for reducing pain, inflammation and edema, promoting healing of wounds, deeper tissues and nerves, and preventing cell death and tissue damage has been known for over forty years since the invention of lasers. Despite many reports of positive findings from experiments conducted in vitro, in animal models and in randomized controlled clinical trials, LLLT remains controversial in mainstream medicine. The biochemical mechanisms underlying the positive effects are incompletely understood, and the complexity of rationally choosing amongst a large number of illumination parameters such as wavelength, fluence, power density, pulse structure and treatment timing has led to the publication of a number of negative studies as well as many positive ones. A biphasic dose response has been frequently observed where low levels of light have a much better effect on stimulating and repairing tissues than higher levels of light. The so-called Arndt-Schulz curve is frequently used to describe this biphasic dose response. This review will cover the molecular and cellular mechanisms in LLLT, and describe some of our recent results in vitro and in vivo that provide scientific explanations for this biphasic dose response.
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Hamblin, M. R. (2018) · Photochemistry and Photobiology · doi:10.1111/php.12864 · Cited by 820
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Molecular action mechanisms of solar infrared radiation and heat on human skin
Akhalaya, M. Y., Maksimov, G. V., Rubin, A. B., Lademann, J., & Darvin, M. E. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.03.006 · Cited by 137
Non‐mammalian Hosts and Photobiomodulation: Do All Life‐forms Respond to Light?
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Metadata
- Authors
- Huang, Y.-Y., Chen, A. C.-H., Carroll, J. D., & Hamblin, M. R.
- Venue
- Dose-Response
- Publisher
- SAGE Publications
- Published
- 2009-09-01
- Volume
- 7
- Issue
- 4
- Pages
- 358-83
- ISSN
- 1559-3258 (ISSN-L)
- OpenAlex
- W2135147563
- Cited by
- 1,162
- References
- 80
- FWCI
- 22.78
- Type
- journal article
- Language
- en
- Open access
- gold
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