The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Biphasic Dose Response in Low Level Light Therapy – an Update
Open accessAbstract
Low-level laser (light) therapy (LLLT) has been known since 1967 but still remains controversial due to incomplete understanding of the basic mechanisms and the selection of inappropriate dosimetric parameters that led to negative studies. The biphasic dose-response or Arndt-Schulz curve in LLLT has been shown both in vitro studies and in animal experiments. This review will provide an update to our previous ( Huang et al. 2009 ) coverage of this topic. In vitro mediators of LLLT such as adenosine triphosphate (ATP) and mitochondrial membrane potential show biphasic patterns, while others such as mitochondrial reactive oxygen species show a triphasic dose-response with two distinct peaks. The Janus nature of reactive oxygen species (ROS) that may act as a beneficial signaling molecule at low concentrations and a harmful cytotoxic agent at high concentrations, may partly explain the observed responses in vivo. Transcranial LLLT for traumatic brain injury (TBI) in mice shows a distinct biphasic pattern with peaks in beneficial neurological effects observed when the number of treatments is varied, and when the energy density of an individual treatment is varied. Further understanding of the extent to which biphasic dose responses apply in LLLT will be necessary to optimize clinical treatments.
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Cites
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Biphasic Dose Response in Low Level Light Therapy
Huang, Y.-Y., Chen, A. C.-H., Carroll, J. D., & Hamblin, M. R. (2009) · Dose-Response · doi:10.2203/dose-response.09-027.hamblin · Cited by 1,162
Self-citationExact Action Spectra for Cellular Responses Relevant to Phototherapy
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Chen, A. C.-H., Arany, P. R., Huang, Y.-Y., Tomkinson, E. M., Sharma, S. K., Kharkwal, G. B., Saleem, T., Mooney, D., Yull, F. E., Blackwell, T. S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022453 · Cited by 522
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Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation
Hamblin, M. R. (2018) · Photochemistry and Photobiology · doi:10.1111/php.12864 · Cited by 820
Self-citationNon‐mammalian Hosts and Photobiomodulation: Do All Life‐forms Respond to Light?
Hamblin, M. R., Huang, Y., & Heiskanen, V. (2019) · Photochemistry and Photobiology · doi:10.1111/php.12951 · Cited by 58
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Metadata
- Authors
- Huang, Y.-Y., Sharma, S. K., Carroll, J., & Hamblin, M. R.
- Venue
- Dose-Response
- Publisher
- SAGE Publications
- Published
- 2011-09-02
- Volume
- 9
- Issue
- 4
- Pages
- 602-18
- ISSN
- 1559-3258 (ISSN-L)
- OpenAlex
- W2126344303
- Cited by
- 854
- References
- 35
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- gold
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