FDG PET Evaluation of Mucinous Neoplasms: Correlation of FDG Uptake with Histopathologic Features
Abstract
Objective Our goal was to assess the sensitivity of positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) for the detection of mucinous carcinoma and to determine the histologic features of these tumors that may affect lesion detectability. Materials and methods A retrospective review of all patients with mucinous carcinoma who had undergone FDG PET at our institution from 1995 through 1998 identified 25 patients with new or recurrent mucinous carcinoma at the time of PET. In 22 of these patients, tissue specimens available from either core biopsy or surgical resection allowed detailed histologic analysis. Results FDG PET revealed mucinous carcinoma in only 13 (59%) of 22 patients, resulting in an unusually high percentage (41%) of false-negative results. Two histologic features were found to be predictive of FDG PET results: tumor cellularity (p = 0.011) and the amount of mucin within the tumor mass (p = 0.009). There was a positive correlation between tumor FDG uptake and cellularity but a negative correlation with the amount of mucin. Conclusion FDG PET is limited in the evaluation of mucinous tumors, particularly in hypocellular lesions with abundant mucin.
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In oncology, [18F]FDG's lack of specificity hampers the differentiation between benign lesions and well-differentiated malignant lesions with low [18F]FDG avidity.
“or benign lesions and well-differentiated malignant lesions with low [18F]FDG avidity [122,123,124,125].”
From Influences on PET Quantification and Interpretation (2022) · cites this paper as [122]
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- Authors
- Berger, K. L., Nicholson, S. A., Dehdashti, F., & Siegel, B. A.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- American Journal of Roentgenology
- Publisher
- American Roentgen Ray Society
- Published
- 2000-04
- Volume
- 174
- Issue
- 4
- Pages
- 1005-1008
- ISSN
- 0002-9580 (ISSN-L)
- 0361-803X
- 1546-3141
- OpenAlex
- W1748631556
- Cited by
- 351
- References
- 25
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 10 · 2023: 12 · 2022: 16 · 2021: 13 · 2020: 15 · 2019: 22 · 2018: 9 · 2017: 8 · 2016: 12 · 2015: 12 · 2014: 16 · 2013: 16 · 2012: 24
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Roentgenology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Health Sciences › Medicine › Oncology › Cancer Diagnosis and Treatment
- Keywords
- FDG-PET, mucinous carcinoma, 18F-fluorodeoxyglucose, tumor cellularity, false-negative results
- MeSH terms
- Adult, Aged, Adenocarcinoma, Mucinous, Female, Humans, Male, Middle Aged, Retrospective Studies, Sensitivity and Specificity, Tomography, Emission-Computed, Radiopharmaceuticals, Fluorodeoxyglucose F18
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