Spectrum of MRI Appearances of Untreated Metastases of the Liver

Abstract

OBJECTIVE: The purpose of our study was to identify the spectrum of MRI appearances of untreated liver metastases from different primary origins. MATERIALS AND METHODS: Over a period of 52 months, we used our clinical information system to retrospectively identify the first MRIs obtained in 165 consecutive patients who had untreated liver metastases. All patients had histologic confirmation of the primary tumor. Liver metastases were confirmed at histologic examination, on imaging, or at clinical follow-up. MR sequences used included T1-weighted spoiled gradient-echo, T2-weighted half-Fourier acquisition single-shot turbo spin-echo, and serial gadolinium-enhanced spoiled gradient-echo imaging. Size, signal intensity characteristics, and pattern of enhancement of the metastases on MRIs were evaluated by two radiologists in consensus. Lesions were categorized by size: smaller than 1.5 cm, between 1.5 and 3.0 cm, and larger than 3.0 cm. RESULTS: A total of 516 metastases (size range, 5-120 mm; mean, 28 mm) were assessed. Fifty-nine patients had hypervascular lesions, and 106 patients had hypovascular lesions. A significant difference in proportion of tumor vascularity was observed between the primary tumors described as classically hypervascular and those described as classically hypovascular (chi-square test for proportions of 70.8, p < 0.0001). The most common pattern was peripheral ring (72% of patients) seen on the arterial dominant phase images, with incomplete central progression (63%) seen on the delayed phase images. A hypointense ring seen in the periphery of the tumor during the delayed phase was the most common appearance in hypervascular metastases (27% patients) and was particularly conspicuous in patients with neuroendocrine and carcinoid tumors. Perilesional enhancement was common (47%), mostly seen in hypovascular metastases (92%). Generally, large lesions tended to show a peripheral ring or heterogeneous enhancement, and small lesions showed homogeneous enhancement. CONCLUSION: MRI allows the identification of a wide spectrum of appearances of untreated liver metastases. The extent and pattern of enhancement of various histologic types of tumor are depicted on MRI.