The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Duration of Treatment with Corticosteroids and Recovery of Kidney Function in Acute Interstitial Nephritis
Open accessAbstract
Background and objectives: Drug-induced acute interstitial nephritis represents an emerging cause of acute kidney disease, especially among polymedicated elderly patients. Although corticosteroids are frequently used, controversy exists about the timing of initiation, efficacy, safety, and duration of treatment. Design, setting, participants, & measurements: We performed a retrospective study of 182 patients with biopsy-proven drug-induced acute interstitial nephritis from 13 Spanish centers. Exposure was defined as the length of corticosteroid treatment. The main outcome was the level of serum creatinine at month 6, with respect to baseline values. Results: The most common offending agents were nonsteroidal anti-inflammatory drugs (27%). In 30% of patients, the offending drug could not be identified. The median time to suspected drug withdrawal was 11 days (interquartile range, 5–22). All patients presented with acute kidney disease and were treated with corticosteroids. The mean initial dose of prednisone was 0.8±0.2 mg/kg per day. High-dose corticosteroid treatment was maintained for 2 weeks (interquartile range, 1–4). After 6 months, the mean recovered GFR was 34±26 ml/min per 1.73 m 2 and ten patients required maintenance dialysis. Use of high-dose corticosteroids for 3 weeks or treatment duration >8 weeks were not associated with better recovery of kidney function. In the multivariable analysis, delayed onset of steroid treatment (odds ratio, 1.02; 95% confidence interval, 1.0 to 1.04) and the presence of interstitial fibrosis of >50% on the kidney biopsy specimen (odds ratio, 8.7; 95% confidence interval, 2.7 to 27.4) were both associated with serum creatinine level at month 6 of >75%, with respect to baseline values. Conclusions: High-dose corticosteroid treatment for 3 weeks or prolonged treatment for >8 weeks were not associated with greater kidney function recovery in drug-induced acute interstitial nephritis. A delay in the initiation of corticosteroids resulted in worse recovery of kidney function.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A recent case series published by Fernandez-Juarez et al. [27] demonstrated that the culprit drug cannot be precisely identified in nearly 30% of cases.”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [27]
Citations
Cites
KDIGO Clinical Practice Guidelines for Acute Kidney Injury
Khwaja, A. (2012) · Nephron Clinical Practice · doi:10.1159/000339789 · Cited by 8,297
Praga, M., & González, E. (2010) · Kidney International · doi:10.1038/ki.2010.89 · Cited by 507
Self-citationGonzález, E., Gutiérrez, E., Galeano, C., Chevia, C., de Sequera, P., Bernis, C., Parra, E. G., Delgado, R., Sanz, M., Ortiz, M., et al. (2008) · Kidney International · doi:10.1038/sj.ki.5002776 · Cited by 466
Self-citationThe changing profile of acute tubulointerstitial nephritis
Baker, R. J., & Pusey, C. D. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg464 · Cited by 347
Acute interstitial nephritis: clinical features and response to corticosteroid therapy
Clarkson, M. R. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh485 · Cited by 343
Biopsy-proven acute interstitial nephritis, 1993-2011: a case series
Muriithi, A. K., Leung, N., Valeri, A. M., Cornell, L. D., Sethi, S., Fidler, M. E., & Nasr, S. H. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.04.027 · Cited by 337
Haas, M., Spargo, B. H., Wit, E. C., & Meehan, S. M. (2000) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(00)70196-x · Cited by 262
Drug-Induced Hypersensitivity Syndrome
m’rad, M. B., Leclerc‐Mercier, S., Blanche, P., Franck, N., Rozenberg, F., Fulla, Y., Guesmi, M., Rollot, F., Dehoux, M., Guillevin, L., et al. (2009) · Medicine · doi:10.1097/md.0b013e3181a4d1a1 · Cited by 194
Acute interstitial nephritis â a reappraisal and update
Raghavan, R., & Eknoyan, G. (2014) · Clinical Nephrology · doi:10.5414/cn10838 · Cited by 180
Clinical characteristics, causes and outcomes of acute interstitial nephritis in the elderly
Muriithi, A. K., Leung, N., Valeri, A. M., Cornell, L. D., Sethi, S. M., Fidler, M. E., & Nasr, S. H. (2014) · Kidney International · doi:10.1038/ki.2014.294 · Cited by 138
Cited by
Sorted by citations
Clinical features and outcomes of immune checkpoint inhibitor-associated AKI: a multicenter study
Cortazar, F. B., Kibbelaar, Z. A., Glezerman, I. G., Abudayyeh, A., Mamlouk, O., Motwani, S. S., Murakami, N., Herrmann, S. M., Manohar, S., Shirali, A. C., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2019070676 · Cited by 407
Drug-Induced Acute Kidney Injury
Perazella, M. A., & Rosner, M. H. (2022) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.11290821 · Cited by 357
Overview of Antibiotic-Induced Nephrotoxicity
Campbell, R. E., Chen, C. H., & Edelstein, C. L. (2023) · Kidney International Reports · doi:10.1016/j.ekir.2023.08.031 · Cited by 157
Manohar, S., Ghamrawi, R., Chengappa, M., Goksu, B. N. B., Kottschade, L., Finnes, H. D., Dronca, R., Leventakos, K., Herrmann, J., & Herrmann, S. M. (2020) · Kidney360 · doi:10.34067/kid.0000152019 · Cited by 52
Facing the Challenge of Drug-Induced Acute Interstitial Nephritis
Álamo, B. S., Cases‐Corona, C., & Juarez, G. M. F. (2022) · The Nephron journals/Nephron journals · doi:10.1159/000525561 · Cited by 71
Metadata
- Authors
- Fernandez-Juarez, G., Perez, J. V., Caravaca-Fontán, F., Quintana, L., Shabaka, A., Rodriguez, E., Gadola, L., de Lorenzo, A., Cobo, M. A., Oliet, A., Sierra, M., Cobelo, C., Iglesias, E., Blasco, M., Galeano, C., Cordon, A., Oliva, J., Praga, M., & on behalf of the Spanish Group for the Study of Glomerular Diseases (GLOSEN)
- Affiliations
- Department of Nephrology, Hospital Fundación de Alcorcón, Madrid, Spain;
- Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain;
- Hospital Clínic de Barcelona (ES)
- Hospital Clínico San Carlos (ES)
- Department of Nephrology, Hospital del Mar, Barcelona, Spain;
- Universidad de la República de Uruguay (UY)
- Hospital Universitario de Getafe (ES)
- Department of Nephrology Hospital Universitario General de Canarias, Tenerife, Spain;
- Hospital Universitario Severo Ochoa (ES)
- Hospital San Pedro (ES)
- Hospital Universitario Lucus Augusti (ES)
- Department of Nephrology, Complejo Hospitalario Universitario de Orense, Orense, Spain;
- Hospital Universitario Ramón y Cajal (ES)
- Hospital Universitario Fundación Alcorcón (ES)
- Instituto de Salud Carlos III (ES)
- Hospital Universitario 12 De Octubre (ES)
- ORCID
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2018-11-05
- Volume
- 13
- Issue
- 12
- Pages
- 1851-1858
- ISSN
- 1555-9041 (ISSN-L)
- 1555-905X
- PMC
- PMC6302327
- OpenAlex
- W2900322133
- Cited by
- 133
- References
- 19
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 16 · 2023: 13 · 2022: 29 · 2021: 14 · 2020: 18 · 2019: 10 · 2018: 2
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Journal of the American Society of Nephrology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Nephrology › Nephrotoxicity and Medicinal Plants
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Keywords
- drug-induced acute interstitial nephritis, corticosteroid treatment duration, renal function recovery, acute kidney injury, prednisone, nonsteroidal anti-inflammatory drugs, interstitial fibrosis, serum creatinine, chronic dialysis, elderly patients
- MeSH terms
- Acute Disease, Aged, Female, Glucocorticoids, Humans, Kidney, Kidney Function Tests, Male, Middle Aged, Nephritis, Interstitial, Prednisone, Retrospective Studies, Time Factors, Recovery of Function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
