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Regulation of Potassium Homeostasis
Open accessAbstract
Potassium is the most abundant cation in the intracellular fluid, and maintaining the proper distribution of potassium across the cell membrane is critical for normal cell function. Long-term maintenance of potassium homeostasis is achieved by alterations in renal excretion of potassium in response to variations in intake. Understanding the mechanism and regulatory influences governing the internal distribution and renal clearance of potassium under normal circumstances can provide a framework for approaching disorders of potassium commonly encountered in clinical practice. This paper reviews key aspects of the normal regulation of potassium metabolism and is designed to serve as a readily accessible review for the well informed clinician as well as a resource for teaching trainees and medical students.
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“An increase in ALD concentration leads to a modest increase in Na+-K+-ATPase abundance, which increases K+ flux into cells [30–32].”
From A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls (2022) · cites this paper as [31]
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Metadata
- Authors
- Palmer, B. F.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Palmer, Biff F.
- ORCID
- Palmer, Biff F.
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2015-06
- Volume
- 10
- Issue
- 6
- Pages
- 1050-1060
- ISSN
- 1555-9041 (ISSN-L)
- PMC
- PMC4455213
- OpenAlex
- W2147621031
- Cited by
- 535
- References
- 93
- Citations by year
- 2026: 51 · 2025: 40 · 2024: 59 · 2023: 65 · 2022: 63 · 2021: 46 · 2020: 57 · 2019: 47 · 2018: 36 · 2017: 42 · 2016: 20 · 2015: 8
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Journal of the American Society of Nephrology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Potassium and Related Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- potassium homeostasis, potassium metabolism, renal potassium excretion, intracellular fluid, potassium disorders
- MeSH terms
- Aldosterone, Animals, Circadian Rhythm, Homeostasis, Humans, Hypertension, Kidney, Potassium, Renin-Angiotensin System, Renal Elimination
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