Cited by 538Potassium and Related DisordersIon Transport and Channel RegulationParathyroid Disorders and Treatments

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Regulation of Potassium Homeostasis

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Palmer, Biff F.·2015·Clinical Journal of the American Society of Nephrology

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Abstract

Potassium is the most abundant cation in the intracellular fluid, and maintaining the proper distribution of potassium across the cell membrane is critical for normal cell function. Long-term maintenance of potassium homeostasis is achieved by alterations in renal excretion of potassium in response to variations in intake. Understanding the mechanism and regulatory influences governing the internal distribution and renal clearance of potassium under normal circumstances can provide a framework for approaching disorders of potassium commonly encountered in clinical practice. This paper reviews key aspects of the normal regulation of potassium metabolism and is designed to serve as a readily accessible review for the well informed clinician as well as a resource for teaching trainees and medical students.

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Authors: Palmer, B. F.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Palmer, Biff F.
ORCID: Palmer, Biff F.
Venue: Clinical Journal of the American Society of Nephrology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-06
Volume: 10
Issue: 6
Pages: 1050-1060
ISSN: 1555-9041 (ISSN-L)
DOI: 10.2215/cjn.08580813
PMC: PMC4455213
OpenAlex: W2147621031
Cited by: 535
References: 93
Citations by year: 2026: 51 · 2025: 40 · 2024: 59 · 2023: 65 · 2022: 63 · 2021: 46 · 2020: 57 · 2019: 47 · 2018: 36 · 2017: 42 · 2016: 20 · 2015: 8
FWCI: 4.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Clinical Journal of the American Society of Nephrology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Nephrology › Potassium and Related Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Keywords: potassium homeostasis, potassium metabolism, renal potassium excretion, intracellular fluid, potassium disorders
MeSH terms: Aldosterone, Animals, Circadian Rhythm, Homeostasis, Humans, Hypertension, Kidney, Potassium, Renin-Angiotensin System, Renal Elimination

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