Phenylpropanoids, eugenol scaffold, and its derivatives as anticancer
Open accessAbstract
ABSTRACTEugenol (EU) is a phenylpropene, an allyl chain-substituted guaiacol. EU is a member of the phenylpropanoids class of chemical compounds. It is acolorless to pale yellow oily liquid extracted from certain essential oils especially from clove oil. Further, chemopreventive agents might be used singlyor in combination with chemotherapy or radiotherapy for the more effective treatment of cancer by enhancing the efficacy of these modalities withminimal side effects and toxicity. Considering that EU scaffold may be a prospective chemopreventive agent, its potent antitumor ability to interferewith solid cancer cell growth and its molecular mechanism were evaluated as an initiative toward the development of a novel strategy for cancertreatment. This review article will conduct that EU as the antiproliferative activity and molecular mechanism of the EU induced apoptosis against thecancer cells and animal models.Keywords: Eugenol, Derivatives of eugenol, Scaffold, Anticancer, Phenylpropanoids.
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Eugenol inhibits tumor proliferation and formation, increases reactive oxygen species (ROS), generates apoptosis, and has a genotoxic effect in different cancer cells.
“Eugenol inhibits tumor proliferation and formation, increases reactive oxygen species (ROS), generates apoptosis, and has a genotoxic effect in different cancer cells [23,29,30,31].”
From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [30]
The Introduction (page not specified) reports that eugenol inhibits proliferation in several cancer cell types and increases ROS, leading to DNA fragmentation and apoptosis. The review also discusses melanoma growth inhibition in vivo, but the passages do not establish inhibition of tumor formation; they describe DNA fragmentation as part of apoptosis rather than a separately demonstrated genotoxic effect. (LLM, conf=0.84)
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Haro-González, J. N., Castillo-Herrera, G. A., Martínez-Velázquez, M., & Espinosa-Andrews, H. (2021) · Molecules · doi:10.3390/molecules26216387 · Cited by 463 · see citing works
- Authors
- Fadilah, F., Yanuar, A., Arsianti, A., & Andrajati, R.
- Affiliations
- University of Indonesia (ID)
- Venue
- Asian Journal of Pharmaceutical and Clinical Research
- Publisher
- Innovare Academic Sciences Pvt Ltd
- Published
- 2017-03-01
- Volume
- 10
- Issue
- 3
- Pages
- 41
- ISSN
- 0974-2441 (ISSN-L)
- 2455-3891
- OpenAlex
- W2594522142
- Cited by
- 28
- References
- 44
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 2
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Asian Journal of Pharmaceutical and Clinical Research (publishedVersion, cc-by-nc)
- Funders
- Universitas Indonesia
- Fakultas Farmasi, Universitas Indonesia
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- eugenol, phenylpropanoids, eugenol derivatives, anticancer agents, chemoprevention, apoptosis, antiproliferative activity, clove oil, essential oils
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