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Carbamazepine, HLA-B*1502 and Risk of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: US FDA Recommendations
Open accessAbstract
Recently, the USA FDA has made a labeling change to the drug information contained in carbamazepine. Owing to recent data implicating the HLA allele B*1502 as a marker for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese, the FDA recommends genotyping all Asians for the allele. This allele is seen in high frequency in many Asian populations other than Han Chinese, but there are few data on whether the allele is a marker for this severe outcome in anyone other than Han Chinese. In fact, the association has not been found in Caucasian patients. We review the data that prompted this recommendation, list data for other ethnic groups, both Asian and non-Asian, and briefly discuss the implication of this recommendation for clinical practice.
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Rzany, B., Correia, O., Kelly, J. P., Naldi, L., Auquier, A., & Stern, R. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05418-x · Cited by 348
Cited by
Next generation disparities in human genomics: concerns and remedies
Need, A. C., & Goldstein, D. B. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.09.012 · Cited by 398
Phillips, E. J., Sukasem, C., Whirl‐Carrillo, M., Müller, D. J., Dunnenberger, H. M., Chantratita, W., Goldspiel, B., Chen, Y., Carleton, B. C., George, A. L., et al. (2018) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1004 · Cited by 328
Hinds, D. A., McMahon, G., Kiefer, A. K., Do, C. B., Eriksson, N., Evans, D. M., St Pourcain, B., Ring, S. M., Mountain, J. L., Francke, U., et al. (2013) · Nature Genetics · doi:10.1038/ng.2686 · Cited by 246
Metadata
- Authors
- Ferrell, P. B., & McLeod, H. L.
- Venue
- Pharmacogenomics
- Publisher
- Informa UK Limited
- Published
- 2008-10
- Volume
- 9
- Issue
- 10
- Pages
- 1543-1546
- ISSN
- 1462-2416 (ISSN-L)
- 1744-8042
- OpenAlex
- W1983783995
- Cited by
- 439
- References
- 1
- FWCI
- 14.48
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Carbamazepine, HLA-B*1502 and Risk of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: US FDA Recommendations. https://app.cochat.ai/papers/10.2217/14622416.9.10.1543
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- Ferrell, P. B., & McLeod, H. L. (2008). Carbamazepine, HLA-B*1502 and Risk of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: US FDA Recommendations. Pharmacogenomics. https://doi.org/10.2217/14622416.9.10.1543
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