A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci
Open accessAbstract
Allergic disease is very common and carries substantial public-health burdens. We conducted a meta-analysis of genome-wide associations with self-reported cat, dust-mite and pollen allergies in 53,862 individuals. We used generalized estimating equations to model shared and allergy-specific genetic effects. We identified 16 shared susceptibility loci with association P<5×10(-8), including 8 loci previously associated with asthma, as well as 4p14 near TLR1, TLR6 and TLR10 (rs2101521, P=5.3×10(-21)); 6p21.33 near HLA-C and MICA (rs9266772, P=3.2×10(-12)); 5p13.1 near PTGER4 (rs7720838, P=8.2×10(-11)); 2q33.1 in PLCL1 (rs10497813, P=6.1×10(-10)), 3q28 in LPP (rs9860547, P=1.2×10(-9)); 20q13.2 in NFATC2 (rs6021270, P=6.9×10(-9)), 4q27 in ADAD1 (rs17388568, P=3.9×10(-8)); and 14q21.1 near FOXA1 and TTC6 (rs1998359, P=4.8×10(-8)). We identified one locus with substantial evidence of differences in effects across allergies at 6p21.32 in the class II human leukocyte antigen (HLA) region (rs17533090, P=1.7×10(-12)), which was strongly associated with cat allergy. Our study sheds new light on the shared etiology of immune and autoimmune disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SNPs in LRRC32 have been strongly associated with allergic rhinitis in three genome-wide association studies and with asthma, eczema, and other allergy-related comorbidities.
“SNPs in leucine-rich repeat-containing protein 32 (LRRC32) have been strongly associated with AR in 3 of the GWASs,486-488 and with asthma,487,489 eczema,488,490 and other allergy-related comorbidities.486,489,491”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [487]
In the main text (page unavailable), the paper identifies LRRC32 as a locus where allergy and autoimmune disease share risk alleles. Its exploratory analysis examines rhinitis and asthma symptoms across allergy loci, but does not establish an LRRC32-specific association with rhinitis in three GWAS or with asthma and eczema individually. Those specifics are not supported by our copy. (LLM, conf=0.83)
Experimental — accuracy not yet measuredA large-scale GWAS on self-reported cat, house dust mite, and pollen allergies, as well as allergic rhinitis, revealed 16 shared susceptibility loci with strong association (p < 5 × 10−8; TLR-locus top hit).
“These associations suggest shared genetic mechanisms for AR and other allergy-related diseases, evidence further supported by the large-scale GWAS on self-reported cat, HDM, and pollen allergies (as well as AR), which revealed 16 shared susceptibility loci with strong association (p < 5 × 10−8; TLR-locus top hit).487”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [487]
The paper’s opening summary (page not specified) reports a GWAS meta-analysis of self-reported cat, dust-mite, and pollen allergy that identified 16 shared loci at P<5×10−8; the TLR1/TLR6/TLR10-region locus has the strongest reported association. But allergic rhinitis was not one of the three phenotypes in that meta-analysis. The paper assessed rhinitis symptoms separately in an exploratory analysis, so the claim overstates its role in the 16-locus finding. (LLM, conf=0.89)
Experimental — accuracy not yet measuredSNPs in different TLRs have been associated with allergic rhinitis in both genome-wide association studies (TLR1, TLR6, TLR10) and candidate gene studies (TLR8).
“SNPs in different TLRs have been associated with AR in both GWASs (TLR1, TLR6, TLR10)486,487 and candidate gene studies (TLR8), as discussed in the next paragraph.494”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [487]
The paper’s main findings report a genome-wide association for a locus near TLR1, TLR6, and TLR10, but the primary phenotype was self-reported cat, dust-mite, and pollen allergy, not allergic rhinitis specifically. Its exploratory analysis of rhinitis symptoms says effects at all index SNPs were in the same direction, without establishing a rhinitis association for the TLR locus in the passage available. The TLR8 candidate-gene claim is attached to a different citation and is not judged here (main text; page unavailable). (LLM, conf=0.86)
Experimental — accuracy not yet measuredAn accompanying GWAS on allergic sensitization showed strong overlap between top hits for sensitization and self-reported allergies.
“In an accompanying GWAS on allergic sensitization, there was strong overlap between top hits for sensitization and self-reported allergies.487,493”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [487]
The associations of LRRC32 with allergic rhinitis and other allergy-related diseases suggest shared genetic mechanisms.
“These associations suggest shared genetic mechanisms for AR and other allergy-related diseases, evidence further supported by the large-scale GWAS on self-reported cat, HDM, and pollen allergies (as well as AR), which revealed 16 shared susceptibility loci with strong association (p < 5 × 10−8; TLR-locus top hit).487”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [487]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
Longitudinal data analysis using generalized linear models
LIANG, K.-Y., & ZEGER, S. L. (1986) · Biometrika · doi:10.1093/biomet/73.1.13 · Cited by 18,550 · see citing works
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072 · see citing works
Statistical Methods for Research Workers
Fisher, R. A. (1945) · American Journal of Clinical Pathology · doi:10.1093/ajcp/15.11.552b · Cited by 10,883 · see citing works
Falush, D., Stephens, M., & Pritchard, J. K. (2003) · Genetics · doi:10.1093/genetics/164.4.1567 · Cited by 7,920 · see citing works
A map of human genome variation from population-scale sequencing.
The 1000 Genomes Project Consortium (2010) · Nature · doi:10.1038/nature09534 · Cited by 7,877 · see citing works
METAL: fast and efficient meta-analysis of genomewide association scans
Willer, C. J., Li, Y., & Abecasis, G. R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq340 · Cited by 5,205 · see citing works
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438 · see citing works
Hindorff, L. A., Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S., & Manolio, T. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903103106 · Cited by 4,013 · see citing works
Browning, S. R., & Browning, B. L. (2007) · The American Journal of Human Genetics · doi:10.1086/521987 · Cited by 3,138 · see citing works
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J. H., Lanier, L. L., & Spies, T. A. (1999) · Science · doi:10.1126/science.285.5428.727 · Cited by 3,000 · see citing works
Franke, A., McGovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., Balschun, T., Lee, J., Roberts, R., et al. (2010) · Nature Genetics · doi:10.1038/ng.717 · Cited by 2,520 · see citing works
Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort
Fraser, A., Macdonald-Wallis, C., Tilling, K., Boyd, A., Golding, J., Davey Smith, G., Henderson, J., Macleod, J., Molloy, L., Ness, A., et al. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dys066 · Cited by 2,494 · see citing works
Self-citationWard, L. D., & Kellis, M. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr917 · Cited by 2,229 · see citing works
A Large-Scale, Consortium-Based Genomewide Association Study of Asthma
Moffatt, M. F., Gut, I. G., Démenais, F., Strachan, D. P., Bouzigon, E., Heath, S. C., von Mutius, E., Farrall, M., Lathrop, M. G., & Cookson, W. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0906312 · Cited by 2,003 · see citing works
TheRPackagegeepackfor Generalized Estimating Equations
Halekoh, U., Højsgaard, S., & Yan, J. (2006) · Journal of Statistical Software · doi:10.18637/jss.v015.i02 · Cited by 1,921 · see citing works
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
Li, Y., Willer, C. J., Ding, J., Scheet, P., & Abecasis, G. R. (2010) · Genetic Epidemiology · doi:10.1002/gepi.20533 · Cited by 1,843 · see citing works
The UCSC Genome Browser database: update 2011
Fujita, P. A., Rhead, B. L., Zweig, A. S., Hinrichs, A. S., Karolchik, D., Cline, M., Goldman, M. J., Barber, G. P., Clawson, H., Coelho, A., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq963 · Cited by 1,836 · see citing works
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
Howie, B., Fuchsberger, C., Stephens, M., Marchini, J., & Abecasis, G. R. (2012) · Nature Genetics · doi:10.1038/ng.2354 · Cited by 1,737 · see citing works
The UCSC Genome Browser Database: update 2006
Hinrichs, A. S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj144 · Cited by 1,646 · see citing works
Anderson, C. A., Boucher, G., Lees, C. W., Franke, A., D’Amato, M., Taylor, K. D., Lee, J. C., Goyette, P., Imielinski, M. B., Latiano, A., et al. (2011) · Nature Genetics · doi:10.1038/ng.764 · Cited by 1,312 · see citing works
Family size, infection and atopy: the first decade of the 'hygiene hypothesis'
Strachan, D. (2000) · Thorax · doi:10.1136/thorax.55.suppl_1.s2 · Cited by 1,183 · see citing works
The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation
Study, T. I. H. C. (2010) · Science · doi:10.1126/science.1195271 · Cited by 1,162 · see citing works
Romagnani, S. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)80019-9 · Cited by 1,063 · see citing works
Strange, A., Spencer, C. C. A., Band, G., Bellenguez, C., Freeman, C., Pirinen, M., Rautanen, A., Su, Z., Donnelly, P., Capon, F., et al. (2010) · Nature Genetics · doi:10.1038/ng.694 · Cited by 1,042 · see citing works
Self-citationMultiple common variants for celiac disease influencing immune gene expression
Dubois, P. C. A., Trynka, G., Franke, L., Hunt, K. A., Romanos, J., Curtotti, A., Zhernakova, A., Heap, G., Ádány, R., Aromaa, A. J., et al. (2010) · Nature Genetics · doi:10.1038/ng.543 · Cited by 1,026 · see citing works
Evans, D. M., Spencer, C. C. A., Pointon, J. J., Su, Z., Harvey, D., Kochan, G. T., Oppermann, U. C. T., Dilthey, A., Pirinen, M., Stone, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.873 · Cited by 891 · see citing works
Self-citationLoci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Aulchenko, Y. S., Janssens, A. C. J. W., Albert Hofman, D., Isaacs, A. J., Sijbrands, E. J. G., Witteman, J. C. M., van Duijn, C. M., Ripatti, S., Lindqvist, I., Perola, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.269 · Cited by 846 · see citing works
(MCAAS), M. C. C. A. S., Ober, C., study, C. H. S. (. A. H., Genetics of Asthma in Latino Americans (GALA) Study, T. S. O. G.-E. A. A. I. L. A. (. A. T. S. O. A. A., (CAMP), C. A. M. P., (SAPPHIRE), S. O. A. P. A. P. I. B. R.-E., & Nicolae, D. L. (2011) · Nature Genetics · doi:10.1038/ng.888 · Cited by 833 · see citing works
Newly identified genetic risk variants for celiac disease related to the immune response
Hunt, K. A., Zhernakova, A., Turner, G., Heap, G., Franke, L., Bruinenberg, M., Romanos, J., Dinesen, L. C., Ryan, A. W., Panesar, D., et al. (2008) · Nature Genetics · doi:10.1038/ng.102 · Cited by 675 · see citing works
Arbes Jr., S. J., Gergen, P. J., Elliott, L., & Zeldin, D. C. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.05.017 · Cited by 639 · see citing works
Discovering susceptibility genes for asthma and allergy
Vercelli, D. (2008) · Nature Reviews Immunology · doi:10.1038/nri2257 · Cited by 635 · see citing works
Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility
Zeller, T., Wild, P. S., Szymczak, S., Rotival, M., Schillert, A., Castagné, R., Maouche, S., Germain, M., Lackner, K. J., Rossmann, H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010693 · Cited by 584 · see citing works
Yao, C., Sakata, D., Esaki, Y., Li, Y., Matsuoka, T., Kuroiwa, K., Sugimoto, Y., & Narumiya, S. (2009) · Nature Medicine · doi:10.1038/nm.1968 · Cited by 566 · see citing works
Libioulle, C., Louis, E. J., Hansoul, S., Sandor, C., Farnir, F., Franchimont, D. P., Vermeire, S., Dewit, O., Vos, M. D., Dixon, A., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030058 · Cited by 561 · see citing works
Toll-like receptor 2 as a major gene for asthma in children of European farmers
Eder, W., Klimecki, W. J., Yu, L., von Mutius, E., Riedler, J., Braun‐Fahrländer, C., Nowak, D., & Martínez, F. D. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.12.374 · Cited by 509 · see citing works
Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits
Eriksson, N., Macpherson, J. M., Tung, J. Y., Hon, L., Naughton, B., Saxonov, S., Avey, L., Wojcicki, A., Pe’er, I., & Mountain, J. L. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000993 · Cited by 480 · see citing works
Self-citationLiao, W., Lin, J.-X., Wang, L., Li, P., & Leonard, W. J. (2011) · Nature Immunology · doi:10.1038/ni.2030 · Cited by 474 · see citing works
Martin, A. M., Nolan, D. A., Gaudieri, S., Almeida, C. A., Nolan, R., JAMES, I. R., Carvalho, F., Phillips, E. J., Christiansen, F., Purcell, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307067101 · Cited by 450 · see citing works
Ferrell, P. B., & McLeod, H. L. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.10.1543 · Cited by 438 · see citing works
Variant of TYR and Autoimmunity Susceptibility Loci in Generalized Vitiligo
Jin, Y., Birlea, S. A., Fain, P. R., Gowan, K., Riccardi, S. L., Holland, P. J., Mailloux, C. M., Sufit, A., Hutton, S. M., Amadi‐Myers, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0908547 · Cited by 415 · see citing works
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma
Ferreira, M. A., Matheson, M. C., Duffy, D. L., Marks, G. B., Hui, J., Le Souëf, P., Danoy, P., Baltic, S., Nyholt, D. R., Jenkins, M., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60874-x · Cited by 381 · see citing works
Paternoster, L., Standl, M., Chen, C., Ramasamy, A., Bønnelykke, K., Duijts, L., Ferreira, M. A. R., Alves, A. C., Thyssen, J. P., Albrecht, E., et al. (2011) · Nature Genetics · doi:10.1038/ng.1017 · Cited by 351 · see citing works
Self-citationGenome-wide Association Analysis Identifies PDE4D as an Asthma-Susceptibility Gene
Himes, B. E., Hunninghake, G. M., Baurley, J. W., Rafaels, N. M., Abou‐Sleiman, P. M., Strachan, D. P., Wilk, J. B., Willis‐Owen, S. A. G., Klanderman, B. J., Lasky-Su, J. A., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.04.006 · Cited by 328 · see citing works
Hirota, T., Takahashi, A., Kubo, M., Tsunoda, T., Tomita, K., Doi, S., Fujita, K., Miyatake, A., Enomoto, T., Miyagawa, T., et al. (2011) · Nature Genetics · doi:10.1038/ng.887 · Cited by 322 · see citing works
Variants of DENND1B Associated with Asthma in Children
Abou‐Sleiman, P. M., Flory, J. H., Imielinski, M. B., Bradfield, J. P., Annaiah, K., Willis‐Owen, S. A. G., Wang, K., Rafaels, N. M., Michel, S., Bønnelykke, K., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901867 · Cited by 321 · see citing works
Kabashima, K., Sakata, D., Nagamachi, M., Miyachi, Y., Inaba, K., & Narumiya, S. (2003) · Nature Medicine · doi:10.1038/nm872 · Cited by 318 · see citing works
A common variant on chromosome 11q13 is associated with atopic dermatitis
Esparza-Gordillo, J., Weidinger, S., Fölster-Holst, R., Bauerfeind, A., Ruschendorf, F., Patone, G., Rohde, K., Marenholz, I., Schulz, F., Kerscher, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.347 · Cited by 317 · see citing works
Compensatory Roles of Foxa1 and Foxa2 during Lung Morphogenesis*
Wan, H.-J., Dingle, S., Xu, Y., Besnard, V., Kaestner, K., Ang, S., Wert, S., Stahlman, M., & Whitsett, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414122200 · Cited by 297 · see citing works
Genome-Wide Association Analysis of Autoantibody Positivity in Type 1 Diabetes Cases
Plagnol, V., Howson, J. M. M., Smyth, D. J., Walker, N. M., Hafler, J. P., Wallace, C., Stevens, H. E., Jackson, L. K., Simmonds, M. J., Bingley, P. J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002216 · Cited by 262 · see citing works
Australian Asthma Genetics Consortium (AAGC), Bønnelykke, K., the EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium, Matheson, M. C., Pers, T. H., Granell, R., Strachan, D. P., Alves, A. C., Linneberg, A., Curtin, J. A., et al. (2013) · Nature Genetics · doi:10.1038/ng.2694 · Cited by 244 · see citing works
Self-citationRamasamy, A., Curjuric, I., Coin, L. J., Kumar, A., McArdle, W. L., Imboden, M., Leynaert, B., Kogevinas, M., Schmid-Grendelmeier, P., Pekkanen, J., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.08.030 · Cited by 222 · see citing works
NFAT pulls the strings during CD4+ T helper cell effector functions
Hermann-Kleiter, N., & Baier, G. (2010) · Blood · doi:10.1182/blood-2009-10-233585 · Cited by 218 · see citing works
Sun, L.-D., Xiao, F.-L., Li, Y., Zhou, W. M., Tang, H.-Y., Tang, X.-F., Zhang, H., Schaarschmidt, H., Zuo, X.-B., Foelster‐Holst, R., et al. (2011) · Nature Genetics · doi:10.1038/ng.851 · Cited by 209 · see citing works
Cryptic Distant Relatives Are Common in Both Isolated and Cosmopolitan Genetic Samples
Henn, B. M., Hon, L., Macpherson, J. M., Eriksson, N., Saxonov, S., Pe’er, I., & Mountain, J. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034267 · Cited by 194 · see citing works
Self-citationHarris, M. B., Chang, C.-C., Berton, M. T., Danial, N. N., Zhang, J., Kuehner, D., Ye, B. H., Kvatyuk, M., Pandolfi, P. P., Cattoretti, G., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7264 · Cited by 186 · see citing works
Inhibition of Th2 Differentiation and GATA-3 Expression by BCL-6
Kusam, S., Toney, L. M., Sato, H., & Dent, A. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.5.2435 · Cited by 165 · see citing works
Toll-like receptor heterodimer variants protect from childhood asthma
Kormann, M., Depner, M., Hartl, D., Klopp, N., Illig, T., Adamski, J., Vogelberg, C., Weiland, S. K., von Mutius, E., & Kabesch, M. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.04.039 · Cited by 155 · see citing works
HLA‐DR and HLA‐DP genotypes and immunoglobulin E responses to common major allergens
Young, R. P., DEKKER, J. W., Wordsworth, B. P., Schou, C., Pile, K., Matthiesen, F., Rosenberg, W. M., Bell, J., Hopkin, J. M., & Cookson, W. O. C. M. (1994) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1994.tb00931.x · Cited by 154 · see citing works
Genome-Wide Association Study for Atopy and Allergic Rhinitis in a Singapore Chinese Population
Andiappan, A. K., Wang, D. Y., Anantharaman, R., Parate, P. N., Suri, B. K., Low, H. Q., Li, Y., Zhao, W., Castagnoli, P. R., Liu, J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019719 · Cited by 102 · see citing works
Tantisira, K. G., Klimecki, W. T., Lazarus, R. M., Palmer, L. J., Raby, B. A., Kwiatkowski, D. J., Silverman, E. K., Vercelli, D., Martínez, F. D., & Weiss, S. T. (2004) · Genes and Immunity · doi:10.1038/sj.gene.6364096 · Cited by 94 · see citing works
Heritability of Self-Reported Asthma and Allergy: A Study in Adult Dutch Twins, Siblings and Parents
Willemsen, G. A. H. M., van Beijsterveldt, T. C. E. M., van Baal, C. G. C. M., Postma, D. S., & Boomsma, D. I. (2008) · Twin Research and Human Genetics · doi:10.1375/twin.11.2.132 · Cited by 84 · see citing works
Distinct Roles of FOXA2 and FOXA3 in Allergic Airway Disease and Asthma
Park, S., Verhaeghe, C., Nguyenvu, L. T., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200811-1768oc · Cited by 79 · see citing works
Kurz, T., Hoffjan, S., Hayes, M. G., Schneider, D., Nicolae, R. I., Heinzmann, A., Jerkic, S. P., Parry, R. R., Cox, N. J., Deichmann, K. A., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.04.036 · Cited by 78 · see citing works
姚, 成. (2011) · Medical Entomology and Zoology · Cited by 69 · see citing works
Heritability and Shared Genetic Effects of Asthma and Hay Fever: An Italian Study of Young Twins
Fagnani, C., Annesi‐Maesano, I., Brescianini, S., D’Ippolito, C., Medda, E., Nisticò, L., Patriarca, V., Rotondi, D., Toccaceli, V., & Stazi, M. A. (2008) · Twin Research and Human Genetics · doi:10.1375/twin.11.2.121 · Cited by 65 · see citing works
Asthma and Allergy in Pregnancy
Schatz, M. X., & Zeiger, R. S. (1997) · Clinics in Perinatology · doi:10.1016/s0095-5108(18)30173-8 · Cited by 65 · see citing works
Smith, H. E., Hogger, C., Lallemant, C., Crook, D., & Frew, A. J. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.11.005 · Cited by 47 · see citing works
HLA genetics and allergic disease.
Howell, W. M., & Holgate, S. T. (1995) · Thorax · doi:10.1136/thx.50.8.815 · Cited by 44 · see citing works
Lin, X., Várnai, P., Csordás, G., Balla, A., Nagai, T., Miyawaki, A., Balla, T., & Hajnóczky, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411591200 · Cited by 39 · see citing works
Karwot, R., Maxeiner, J., Schmitt, S., Scholtes, P., Hausding, M., Lehr, H. A., Glimcher, L. H., & Finotto, S. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.12.1172 · Cited by 35 · see citing works
Wan, Y. I., Strachan, D. P., Evans, D. M., Henderson, J., McKeever, T. M., Holloway, J. W., Hall, I. P., & Sayers, I. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.006 · Cited by 34 · see citing works
Self-citationKarwot, R., Übel, C., Bopp, T., et al. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.01.004 · Cited by 20 · see citing works
Fast computation for genome-wide association studies using boosted one-step statistics
Voorman, A., Rice, K. M., & Lumley, T. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts291 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The genetic ancestry of African Americans, Latinos, and European Americans across the United States
Bryc, K., Durand, E. Y., Macpherson, J. M., Reich, D., & Mountain, J. L. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.11.010 · Cited by 712 · see citing works
Self-citationInternational Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., et al. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22073 · Cited by 557 · see citing works
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Loh, P.-R., Bhatia, G., Gusev, A., Finucane, H. K., Bulik-Sullivan, B. K., Pollack, S. J., de Candia, T. R., Lee, S. H., Wray, N. R., et al. (2015) · Nature Genetics · doi:10.1038/ng.3431 · Cited by 449 · see citing works
Deschamps, M., Laval, G., Fagny, M., Itan, Y., Abel, L., Casanova, J.-L., Patin, E., & Quintana-Murci, L. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.11.014 · Cited by 257 · see citing works
Dannemann, M., Andrés, A. M., & Kelso, J. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.11.015 · Cited by 249 · see citing works
Australian Asthma Genetics Consortium (AAGC), Bønnelykke, K., the EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium, Matheson, M. C., Pers, T. H., Granell, R., Strachan, D. P., Alves, A. C., Linneberg, A., Curtin, J. A., et al. (2013) · Nature Genetics · doi:10.1038/ng.2694 · Cited by 244 · see citing works
Self-citationTylee, D. S., Sun, J., Hess, J. L., Tahir, M. A., Sharma, E., Malik, R., Worrall, B. B., Levine, A. J., Martinson, J. J., Nejentsev, S., et al. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32652 · Cited by 219 · see citing works
Ferreira, M. A. R., Matheson, M. C., Tang, C. S., Granell, R., Ang, W., Hui, J., Kiefer, A. K., Duffy, D. L., Baltic, S., Danoy, P., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.030 · Cited by 216 · see citing works
“To date, GWASs have identified variants in 18 loci for which there are genome-wide significant associations with asthma,(9) including ORMDL3,(10-15) PDE4D,(16) DENND1B,(17) HLA,(11,15,18-21) IL33,(11,12,15) IL1RL1,(11,12,15,20) SMAD3,(11,15) IL2RB,(11) SLC30A8,(18) PYHIN1,(12) TSLP,(12,15) GAB1,(19) IKZF4,(19) 10p14,(…”
BackgroundSelf-citationGenetic risk factors for the development of allergic disease identified by genome‐wide association
Portelli, M. A., Hodge, E., & Sayers, I. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12327 · Cited by 206 · see citing works
Archaic Hominin Admixture Facilitated Adaptation to Out-of-Africa Environments
Gittelman, R. M., Schraiber, J. G., Vernot, B., Mikacenic, C., Wurfel, M. M., & Akey, J. M. (2016) · Current Biology · doi:10.1016/j.cub.2016.10.041 · Cited by 181 · see citing works
The Contribution of Neanderthals to Phenotypic Variation in Modern Humans
Dannemann, M., & Kelso, J. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.09.010 · Cited by 193 · see citing works
Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci
Tsoi, L. C., Spain, S. L., Ellinghaus, E., Stuart, P. E., Capon, F., Knight, J., Tejasvi, T., Kang, H. M., Allen, M. H., Lambert, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms8001 · Cited by 195 · see citing works
Functional implications of Neandertal introgression in modern humans
Dannemann, M., Prüfer, K., & Kelso, J. (2017) · Genome biology · doi:10.1186/s13059-017-1181-7 · Cited by 92 · see citing works
Genetics of allergy and allergic sensitization: common variants, rare mutations
Bønnelykke, K., Sparks, R., Waage, J., & Milner, J. D. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.08.002 · Cited by 73 · see citing works
Molecular Mechanisms of Nasal Epithelium in Rhinitis and Rhinosinusitis
Toppila-Salmi, S., van Drunen, C. M., Fokkens, W. J., Golebski, K., Mattila, P., Joenvaara, S., Renkonen, J., & Renkonen, R. (2015) · Current Allergy and Asthma Reports · doi:10.1007/s11882-014-0495-8 · Cited by 57 · see citing works
Ahuja, S. K., Manoharan, M. S., Harper, N. L., Jimenez, F., Hobson, B. D., Martinez, H., Ingale, P., Liu, Y.-G., Carrillo, A., Lou, Z., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.08.019 · Cited by 18 · see citing works
Characterization of genetic variation in <i><scp>TLR</scp>8</i> in relation to allergic rhinitis
Henmyr, V., Lind‐Halldén, C., Carlberg, D., Halldén, C., Melén, E., Wickman, M., Bergström, A., Säll, T., & Cardell, L. O. (2016) · Allergy · doi:10.1111/all.12805 · Cited by 10 · see citing works
- Authors
- Hinds, D. A., McMahon, G., Kiefer, A. K., Do, C. B., Eriksson, N., Evans, D. M., St Pourcain, B., Ring, S. M., Mountain, J. L., Francke, U., Davey-Smith, G., Timpson, N. J., & Tung, J. Y.
- Affiliations
- 23andMe (United States) (US)
- University of Bristol (GB)
- Corresponding author
- Hinds, David A
- ORCID
- Venue
- Nature Genetics
- Published
- 2013-06-30
- Volume
- 45
- Issue
- 8
- Pages
- 907-911
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC3753407
- OpenAlex
- W2045008815
- Cited by
- 246
- References
- 75
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 14 · 2022: 10 · 2021: 16 · 2020: 14 · 2019: 24 · 2018: 24 · 2017: 31 · 2016: 35 · 2015: 29 · 2014: 28 · 2013: 5
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Bristol Research (University of Bristol) (submittedVersion)
- Funders
- Wellcome Trust (092731)
- University of Bristol
- National Institutes of Health
- Medical Research Council
- National Heart, Lung, and Blood Institute (R43HL115873)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- allergy, self-reported allergy, cat allergy, house dust mite allergy, allergic rhinitis, asthma, genetic susceptibility loci, shared genetic effects, HLA class II region, EP4 receptor, LPP, NFATc2, FOXA1, autoimmune disease genetics
- MeSH terms
- Adult, Aged, Allergens, Animals, Cats, Female, Humans, Hypersensitivity, Male, Middle Aged, Cohort Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Pyroglyphidae, Genome-Wide Association Study, Young Adult, Genetic Loci, Self Report
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
