The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mesoporous Silica Nanomaterial-Based Biotechnological and Biomedical Delivery Systems
Abstract
This review details the recent advancements in the design of mesoporous silica nanomaterials for controlled release drug, gene and neurotransmitter delivery applications. The high surface area (>900 m2/g), tunable pore diameter (2-20 nm) and uniform mesoporous structure (hexagonal channels or cubic pores) of the mesoporous silicas offer a unique advantage for loading and releasing large quantities of biomedical agents. Recent breakthroughs in controlling the particle size and shape of these materials have greatly improved the biocompatibility and the cellular uptake efficiency. The strategy of using various removable capping moieties, such as photo- or redox-responsive organic groups, inorganic nanoparticles, dendrimers and polymers, to encapsulate guest biomolecules inside the porous matrices further enables the utilization of these surface-functionalized mesoporous silica nanomaterials for stimuli-responsive controlled release in vitro and in vivo. In addition to the reviewed studies, many new and exciting applications of these novel materials will soon be realized.
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Cites
Polymeric systems for controlled drug release
Uhrich, K. E., Cannizzaro, S. M., Langer, R. S., & Shakesheff, K. M. (1999) · Chemical Reviews · doi:10.1021/cr940351u · Cited by 2,633
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J. S., Chin, S.-F., Sherry, A. D., Boothman, D. A., & Gao, J. (2006) · Nano Letters · doi:10.1021/nl061412u · Cited by 1,238
Cited by
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Mesoporous silica nanoparticles in drug delivery and biomedical applications
Wang, Y., Zhao, Q., Han, N., Bai, L., Li, J., Liu, J., Che, E., Hu, L., Zhang, Q., Jiang, T., et al. (2015) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2014.09.014 · Cited by 1,192
Schlossbauer, A., Kecht, J., & Bein, T. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805818 · Cited by 299
Clemens, D. L., Lee, B.-Y., Xue, M., Thomas, C. R., Meng, H., Ferris, D., Nel, A. E., Zink, J. I., & Horwitz, M. A. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.06049-11 · Cited by 260
Metadata
- Authors
- Giri, S., Trewyn, B. G., & Lin, V. S.
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2007-02
- Volume
- 2
- Issue
- 1
- Pages
- 99-111
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2142429646
- Cited by
- 159
- References
- 2
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Giri, S., Trewyn, B. G., & Lin, V. S. (2007). Mesoporous Silica Nanomaterial-Based Biotechnological and Biomedical Delivery Systems. Nanomedicine. https://doi.org/10.2217/17435889.2.1.99
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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