Mesoporous silica nanoparticles in drug delivery and biomedical applications
Abstract
In the past decade, mesoporous silica nanoparticles (MSNs) with a large surface area and pore volume have attracted considerable attention for their application in drug delivery and biomedicine. In this review, we highlight the recent advances in silica-assisted drug delivery systems, including (1) MSN-based immediate/sustained drug delivery systems and (2) MSN-based controlled/targeted drug delivery systems. In addition, we summarize the biomedical applications of MSNs, including (1) MSN-based biotherapeutic agent delivery; (2) MSN-assisted bioimaging applications; and (3) MSNs as bioactive materials for tissue regeneration.From the clinical editor This comprehensive review presents recent advances in mesoporous silica nanoparticles assisted drug delivery systems, including both immediate and sustained delivery systems as well as controlled release and targeted drug delivery systems. In addition to achieving therapeutic agent delivery, imaging applications and potential use of silica NPs in tissue regeneration are also discussed.
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Smart MSNs have the ability to release the loaded medications in response to a variety of stimuli, including redox reaction, pH change, magnetic field, temperature change, enzyme transformation, and light.
“Smart MSNs have the ability to release the loaded medications in response to a variety of stimuli, including redox reaction, pH change, magnetic field, temperature change, enzyme transformation, and light.78”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [78]
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Singh, N., Shi, S., & Goel, S. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114638 · Cited by 35 · see citing works
- Authors
- Wang, Y., Zhao, Q., Han, N., Bai, L., Li, J., Liu, J., Che, E., Hu, L., Zhang, Q., Jiang, T., & Wang, S.
- Affiliations
- Shenyang Pharmaceutical University (CN)
- Corresponding author
- Wang, Siling
- Venue
- Nanomedicine: Nanotechnology, Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 11
- Issue
- 2
- Pages
- 313-327
- ISSN
- 1549-9634 (ISSN-L)
- OpenAlex
- W2058559717
- Cited by
- 1,192
- References
- 105
- Citations by year
- 2026: 49 · 2025: 81 · 2024: 106 · 2023: 100 · 2022: 122 · 2021: 139 · 2020: 131 · 2019: 148 · 2018: 106 · 2017: 106 · 2016: 74 · 2015: 30
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Mesoporous Materials and Catalysis
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Clay minerals and soil interactions
- Keywords
- mesoporous silica nanoparticles, drug delivery, sustained drug release, controlled release, targeted drug delivery, bioimaging, tissue regeneration, bioactive materials
- MeSH terms
- Biocompatible Materials, Humans, Silicon Dioxide, Porosity, Drug Delivery Systems, Nanoparticles
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