5-Aminolevulinic Acid-Conjugated Gold Nanoparticles for Photodynamic Therapy of Cancer
Abstract
BACKGROUND: Effective delivery of photosensitizer to target tumor cells that causes minimal damage to healthy cells is an important requirement in photodynamic therapy of cancer. AIM: We aimed to use biocompatible gold nanoparticles as a vehicle to deliver 5-aminolevulinic (5-ALA) acid for selective and efficient photodynamic therapy. RESULTS: Protoporphyrin IX accumulated preferentially in fibrosarcoma tumor cells treated with 5-ALA-conjugated nanoparticles while yielding significantly higher reactive oxygen species compared with that with 5-ALA. The elevation of reactive oxygen species resulted in 50% more cytotoxicity to tumor cells than that of 5-ALA alone. Selective destruction of tumor cells was also achieved using 5-ALA-conjugated nanoparticles in co-culture with dermal fibroblasts. CONCLUSIONS: 5-ALA-conjugated nanoparticles offer a new modality for selective and efficient destruction of tumor cells, with minimal damage to fibroblasts in the 5-ALA-photodynamic therapy.
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Conjugating 5-aminolevulinic acid to nanoparticles, including biocompatible gold (Au) and chitosan, was suggested to improve ALA delivery to the tumor.
“Conjugating 5-aminolevulinic acid to nanoparticles, including biocompatible gold (Au) and chitosan, was one of the solutions suggested to improve ALA delivery to the tumor [78,79].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [78]
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- Authors
- Khaing Oo, M. K., Yang, X., Du, H., & Wang, H.
- Affiliations
- Department of Chemical Engineering & Materials Science, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ07030, USA
- Stevens Institute of Technology (US)
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2008-11-24
- Volume
- 3
- Issue
- 6
- Pages
- 777-786
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2591368219
- Cited by
- 113
- References
- 25
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 3 · 2019: 8 · 2018: 7 · 2017: 3 · 2016: 8 · 2015: 12 · 2014: 6 · 2013: 9 · 2012: 10
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Keywords
- 5-aminolevulinic acid, gold nanoparticles, photodynamic therapy, photosensitizer delivery, protoporphyrin IX, reactive oxygen species, fibrosarcoma, tumor selectivity, dermal fibroblasts, nanoparticle conjugates
- MeSH terms
- Aminolevulinic Acid, Animals, Fibroblasts, Fibrosarcoma, Gold, Humans, Microscopy, Electron, Scanning, Neoplasms, Photochemotherapy, Spectrophotometry, Ultraviolet, Photosensitizing Agents, Reactive Oxygen Species, Coculture Techniques, Metal Nanoparticles, Static Electricity
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