The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
5-Aminolevulinic Acid-Conjugated Gold Nanoparticles for Photodynamic Therapy of Cancer
Abstract
BACKGROUND: Effective delivery of photosensitizer to target tumor cells that causes minimal damage to healthy cells is an important requirement in photodynamic therapy of cancer. AIM: We aimed to use biocompatible gold nanoparticles as a vehicle to deliver 5-aminolevulinic (5-ALA) acid for selective and efficient photodynamic therapy. RESULTS: Protoporphyrin IX accumulated preferentially in fibrosarcoma tumor cells treated with 5-ALA-conjugated nanoparticles while yielding significantly higher reactive oxygen species compared with that with 5-ALA. The elevation of reactive oxygen species resulted in 50% more cytotoxicity to tumor cells than that of 5-ALA alone. Selective destruction of tumor cells was also achieved using 5-ALA-conjugated nanoparticles in co-culture with dermal fibroblasts. CONCLUSIONS: 5-ALA-conjugated nanoparticles offer a new modality for selective and efficient destruction of tumor cells, with minimal damage to fibroblasts in the 5-ALA-photodynamic therapy.
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“Conjugating 5-aminolevulinic acid to nanoparticles, including biocompatible gold (Au) and chitosan, was one of the solutions suggested to improve ALA delivery to the tumor [78,79].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [78]
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DISTRIBUTION OF 5‐AMINOLEVULINIC ACID‐INDUCED PORPHYRINS IN NODULOULCERATIVE BASAL CELL CARCINOMA
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Fanjul-Vélez, F., & Arce-Diego, J. L. (2018) · Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy · doi:10.1117/12.2290145
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Hybrid modifiers for Ti dental implants
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Biopolymer‐Based Polyelectrolyte Nanoplatforms for Targeted Photodynamic Therapy of Breast Cancer
Narayanan, A., Stanca, B. D. C., Pinheiro, D., Giannotti, L., Damiano, F., Moreira, A. F., Miguel, S. P., Lamanna, L., Stanca, E., Raucci, M. G., et al. (2026) · Open Research (University of Surrey) · doi:10.1002/viw2.70199
Metadata
- Authors
- Khaing Oo, M. K., Yang, X., Du, H., & Wang, H.
- Affiliations
- Department of Chemical Engineering & Materials Science, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ07030, USA
- Stevens Institute of Technology (US)
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2008-11-24
- Volume
- 3
- Issue
- 6
- Pages
- 777-786
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2591368219
- Cited by
- 113
- References
- 25
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 3 · 2019: 8 · 2018: 7 · 2017: 3 · 2016: 8 · 2015: 12 · 2014: 6 · 2013: 9 · 2012: 10
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
- Keywords
- 5-aminolevulinic acid, gold nanoparticles, photodynamic therapy, photosensitizer delivery, protoporphyrin IX, reactive oxygen species, fibrosarcoma, tumor selectivity, dermal fibroblasts, nanoparticle conjugates
- MeSH terms
- Aminolevulinic Acid, Animals, Fibroblasts, Fibrosarcoma, Gold, Humans, Microscopy, Electron, Scanning, Neoplasms, Photochemotherapy, Spectrophotometry, Ultraviolet, Photosensitizing Agents, Reactive Oxygen Species, Coculture Techniques, Metal Nanoparticles, Static Electricity
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