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MALDI-TOF-Mass Spectrometry Applications in Clinical Microbiology
Abstract
MALDI-TOF-mass spectrometry (MS) has been successfully adapted for the routine identification of microorganisms in clinical microbiology laboratories in the past 10 years. This revolutionary technique allows for easier and faster diagnosis of human pathogens than conventional phenotypic and molecular identification methods, with unquestionable reliability and cost-effectiveness. This article will review the application of MALDI-TOF-MS tools in routine clinical diagnosis, including the identification of bacteria at the species, subspecies, strain and lineage levels, and the identification of bacterial toxins and antibiotic-resistance type. We will also discuss the application of MALDI-TOF-MS tools in the identification of Archaea, eukaryotes and viruses. Pathogenic identification from colony-cultured, blood-cultured, urine and environmental samples is also reviewed.
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Citations
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Seng, P., Drancourt, M., Gouriet, F., La Scola, B., Fournier, P., Rolain, J. M., & Raoult, D. (2009) · Clinical Infectious Diseases · doi:10.1086/600885 · Cited by 1,983
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Cited by
Human Gut Microbiota: Repertoire and Variations
Lagier, J.-C., Million, M., Hugon, P., Armougom, F., & Raoult, D. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00136 · Cited by 329
Self-citationEnvironmental Mass Spectrometry: Emerging Contaminants and Current Issues
Richardson, S. D. (2012) · Analytical Chemistry · doi:10.1021/ac202903d · Cited by 323
Hrabák, J., Chudáčková, E., & Walková, R. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00058-12 · Cited by 304
Lactobacillus rhamnosus bacteremia: An emerging clinical entity
Gouriet, F., Million, M., Henri, M., Fournier, P.-E., & Raoult, D. (2012) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-012-1599-5 · Cited by 93
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Metadata
- Authors
- Seng, P., Rolain, J.-M., Fournier, P. E., La Scola, B., Drancourt, M., & Raoult, D.
- Venue
- Future Microbiology
- Publisher
- Informa UK Limited
- Published
- 2010-11
- Volume
- 5
- Issue
- 11
- Pages
- 1733-1754
- ISSN
- 1746-0913 (ISSN-L)
- 1746-0921
- OpenAlex
- W2165258565
- Cited by
- 419
- References
- 1
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Seng, P., Rolain, J.-M., Fournier, P. E., La Scola, B., Drancourt, M., & Raoult, D. (2010). MALDI-TOF-Mass Spectrometry Applications in Clinical Microbiology. Future Microbiology. https://doi.org/10.2217/fmb.10.127
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