The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Matrix-Assisted Laser Desorption Ionization–Time of Flight (MALDI-TOF) Mass Spectrometry for Detection of Antibiotic Resistance Mechanisms: from Research to Routine Diagnosis
Open accessAbstract
SUMMARY: Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) has been successfully applied as an identification procedure in clinical microbiology and has been widely used in routine laboratory practice because of its economical and diagnostic benefits. The range of applications of MALDI-TOF MS has been growing constantly, from rapid species identification to labor-intensive proteomic studies of bacterial physiology. The purpose of this review is to summarize the contribution of the studies already performed with MALDI-TOF MS concerning antibiotic resistance and to analyze future perspectives in this field. We believe that current research should continue in four main directions, including the detection of antibiotic modifications by degrading enzymes, the detection of resistance mechanism determinants through proteomic studies of multiresistant bacteria, and the analysis of modifications of target sites, such as ribosomal methylation. The quantification of antibiotics is suggested as a new approach to study influx and efflux in bacterial cells. The results of the presented studies demonstrate that MALDI-TOF MS is a relevant tool for the detection of antibiotic resistance and opens new avenues for both clinical and experimental microbiology.
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Cites
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Cited by
Current and Emerging Methods of Antibiotic Susceptibility Testing
Khan, Z. A., Siddiqui, M. F., & Park, S. (2019) · Diagnostics · doi:10.3390/diagnostics9020049 · Cited by 442
Harvey, D. J. (2018) · Mass Spectrometry Reviews · doi:10.1002/mas.21530 · Cited by 61
Dai, Y., Li, C., Yi, J., Qin, Q., Liu, B., & Qiao, L. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c00494 · Cited by 31
Metadata
- Authors
- Hrabák, J., Chudáčková, E., & Walková, R.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2013-01
- Volume
- 26
- Issue
- 1
- Pages
- 103-114
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2134190791
- Cited by
- 304
- References
- 56
- FWCI
- 20.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Hrabák, J., Chudáčková, E., & Walková, R. (2013). Matrix-Assisted Laser Desorption Ionization–Time of Flight (MALDI-TOF) Mass Spectrometry for Detection of Antibiotic Resistance Mechanisms: from Research to Routine Diagnosis. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.00058-12
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