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The role of mesenchymal stem cells in oncology and regenerative medicine

Maliha, Khan, Syeda Ezze Rukhshan, Adil, Amanda L, Olson·2017·Future Oncology
DOI 10.2217/fon-2016-0264
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Abstract

Mesenchymal stem cells (MSCs) have long been used as therapeutic agents in disease affecting various organ systems. However, MSCs are fast emerging as promising anticancer agents which have the potential to treat a number of different cancer types, including glioblastoma and metastatic breast, ovarian and hepatic carcinoma. The ability of MSC to migrate directly into the tumor microenvironment and to produce IFN-α and -β makes this possible. However, the possibility of MSC undergoing either malignant transformation or transformation into protumorigenic fibroblasts currently limits their role in clinical use. It is hoped that future research can overcome these limitations and facilitate the use of MSC clinically.

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Cited by

Sorted by citations

  • Mesenchymal stem cell secretome for regenerative medicine: Where do we stand?

    Trigo, C. M., Rodrigues, J. S., Camões, S. P., Solá, S., & Miranda, J. P. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.004 · Cited by 252

    “In the pro-inflammatory tumor microenvironment (TME) occurs the expression of a plethora of chemokines and cytokines, namely VEGF, FGF, PDGF, CCL5 and IL-8, that induce the migration of MSCs towards the tumor in an orchestrated manner by creating a chemokine concentration gradient [101].”

Metadata

Authors
Maliha, K., Syeda Ezze Rukhshan, A., & Amanda L, O.
Affiliations
  • The University of Texas MD Anderson Cancer Center (US)
  • Department of Internal Medicine, Dow University of Health Sciences, Karachi, Pakistan
  • Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Venue
Future Oncology
Publisher
Informa UK Limited
Published
2016-12-02
Volume
13
Issue
9
Pages
821-831
ISSN
  • 1479-6694 (ISSN-L)
  • 1744-8301
DOI
10.2217/fon-2016-0264
OpenAlex
W2557959975
Cited by
5
References
9
Citations by year
2024: 1 · 2023: 1 · 2021: 1 · 2020: 2
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Future Oncology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
Keywords
mesenchymal stem cells, cancer therapy, tumor microenvironment, malignant transformation, glioblastoma, metastatic breast cancer, ovarian cancer, hepatocellular carcinoma, regenerative medicine
MeSH terms
Animals, Cell Movement, Genetic Vectors, Humans, Neoplasm Metastasis, Neoplasm Staging, Neoplasms, Transduction, Genetic, Genetic Therapy, Cytokines, Transgenes, Regenerative Medicine, Mesenchymal Stem Cell Transplantation, Tumor Microenvironment, Mesenchymal Stem Cells

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