The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Tumor-Associated Macrophages: Implications in Cancer Immunotherapy
Open accessAbstract
Tumor-associated macrophages (TAMs), representing most of the leukocyte population in solid tumors, demonstrate great phenotypic heterogeneity and diverse functional capabilities under the influence of the local tumor microenvironment. These anti-inflammatory and protumorigenic macrophages modulate the local microenvironment to facilitate tumor growth and metastasis. In this review, we examine the origin of TAMs and the complex regulatory networks within the tumor microenvironment that facilitate the polarization of TAMs toward a protumoral phenotype. More extensively, we evaluate the mechanisms by which TAMs mediate angiogenesis, metastasis, chemotherapeutic resistance and immune evasion. Lastly, we will highlight novel interventional strategies targeting TAMs in preclinical studies and in early clinical trials that have significant potential in improving efficacy of current chemotherapeutic and/or immunotherapeutic approaches.
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1 retracted
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Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
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Macrophage plasticity and polarization: in vivo veritas
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Macrophage Diversity Enhances Tumor Progression and Metastasis
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Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
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Macrophage biology in development, homeostasis and disease
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Cited by
Keung, E. Z., Burgess, M., Salazar, R., Parra, E. R., Rodrigues-Canales, J., Bolejack, V., Van Tine, B. A., Schuetze, S. M., Attia, S., Riedel, R. F., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1824 · Cited by 215
Thymosin α-1 Reverses M2 Polarization of Tumor-Associated Macrophages during Efferocytosis
Wei, Y.-T., Wang, X.-R., Yan, C., Huang, F., Zhang, Y., Liu, X., Wen, Z.-F., Sun, X.-T., Zhang, Y., Chen, Y.-Q., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-4260 · Cited by 80
Xiong, J., Xiao, R., Zhao, J., Zhao, Q., Luo, M., Li, F., Zhang, W., & Wu, M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04810-3 · Cited by 79
Metadata
- Authors
- Petty, A. J., & Yang, Y.
- Venue
- Immunotherapy
- Publisher
- Informa UK Limited
- Published
- 2017-02-24
- Volume
- 9
- Issue
- 3
- Pages
- 289-302
- ISSN
- 1750-743X (ISSN-L)
- 1750-7448
- OpenAlex
- W2590692536
- Cited by
- 363
- References
- 100
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Petty, A. J., & Yang, Y. (2017). Tumor-Associated Macrophages: Implications in Cancer Immunotherapy. Immunotherapy. https://doi.org/10.2217/imt-2016-0135
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
