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Nanoparticle Transport Across the Placental Barrier: Pushing the Field Forward!
Open accessAbstract
The human placenta is a multifunctional organ constituting the barrier between maternal and fetal tissues. Nanoparticles can cross the placental barrier, and there is increasing evidence that the extent of transfer is dependent on particle characteristics and functionalization. While translocated particles may pose risks to the growing fetus particles may also be engineered to enable new particle-based therapies in pregnancy. In both cases, a comprehensive understanding of nanoparticle uptake, accumulation and translocation is indispensable and requires predictive placental transfer models. We examine and evaluate the current literature to draw first conclusions on the possibility to steer translocation of nanoparticles. In addition, we discuss if current placental models are suitable for nanoparticle transfer studies and suggest strategies to improve their predictability.
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“Evidence from in vivo animal exposure models, ex vivo human placental models, and recent direct evidence from human placentae demonstrate transport of ultrafine particles (UFPs) across the placental barrier indicating possible direct effects on placental function and offspring health [133, 134].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [133]
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Metadata
- Authors
- Muoth, C., Aengenheister, L., Kucki, M., Wick, P., & Buerki-Thurnherr, T.
- Affiliations
- Empa (CH)
- Empa–Swiss Federal Laboratories for Materials Science & Technology, St. Gallen, Switzerland
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2016-03-16
- Volume
- 11
- Issue
- 8
- Pages
- 941-957
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2301631169
- Cited by
- 146
- References
- 88
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 6 · 2023: 16 · 2022: 18 · 2021: 18 · 2020: 23 · 2019: 13 · 2018: 22 · 2017: 7 · 2016: 3
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.dora.lib4ri.ch
- Licence
- other-oa
- Locations
- Nanomedicine (publishedVersion)
- PubMed (publishedVersion)
- DORA Empa (Swiss Federal Laboratories for Materials Science and Technology (Empa)) (submittedVersion, other-oa)
- Funders
- Graphene Flagship
- European Commission
- Leibniz-Gemeinschaft
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- nanoparticle transport, placental barrier, nanoparticle functionalization, particle properties, prenatal exposure, prediction model
- MeSH terms
- Animals, Biological Transport, Female, Humans, Placenta, Pregnancy, Nanotechnology, Nanomedicine, Nanoparticles
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