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Combination of Albendazole and 2-Methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice
Open accessAbstract
BACKGROUND: Albendazole (ABZ) is a microtubule-targeting anthelmintic with a remarkable activity against a variety of human cancer cells. In this study, we examined if the antitumor activity of ABZ could be enhanced by its combination with other microtubule-binding agents. METHODS: The interactions between ABZ and microtubule-binding agents, paclitaxel, vinblastine, colchicine, and 2-methoxyestradiol were characterized using median effect analysis method in HCT-116 colorectal cancer cells and DU145 prostate cancer cell line. The mechanism underlying the synergistic interaction related to tubulin polymerization and apoptosis was then investigated. Finally, the effect of the combination therapy on the survival of HCT-116 tumor-bearing nude mice was evaluated. RESULTS: Among the tested drugs, a synergistic anti-proliferative effect was observed with the combination of low concentrations of ABZ plus colchicine and ABZ plus 2-methoxyestradiol (2ME). Exploring the mechanism of the interaction between ABZ and 2ME revealed that the combination therapy synergistically activated the extrinsic pathway of apoptosis. Consistent with in vitro results, the combination of low concentration of ABZ with 2ME prolonged the survival of mice-bearing HCT-116 tumors. High concentration of ABZ in combination with 2ME, however, proved to be less effective than ABZ alone. CONCLUSIONS: The combination of low doses of ABZ and 2ME has shown promising results in our pre-clinical model. Additionally, the finding that the combination of two microtubule-binding agents that share the same binding site can act synergistically may lead to the development of new therapeutic strategies in cancer treatment.
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Ovarian and prostate and colorectal cancer cells were also suppressed by treatment with albendazole alone or albendazole plus 2-methoxyestradiol by inhibiting tubulin polymerization.
“Ovarian [347] and prostate and colorectal cancer cells [348] were also suppressed by treatment with albendazole alone or albendazole plus 2-methoxyestradiol by inhibiting tubulin polymerization.”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [348]
The Results (page unavailable) report that albendazole plus 2-methoxyestradiol inhibited proliferation of HCT-116 colorectal and DU145 prostate cancer cells at certain doses. But the Discussion (page unavailable) explicitly says this effect was not mediated by inhibition of tubulin polymerization, contrary to the mechanism attributed to this source. The ovarian-cell claim is attached to a different citation in the citing sentence. (LLM, conf=0.88)
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Metadata
- Authors
- Ehteda, A., Galettis, P., Pillai, K., & Morris, D. L.
- Affiliations
- UNSW Sydney (AU)
- St George Hospital (AU)
- Corresponding author
- Ehteda, Anahid
- Venue
- BMC Cancer
- Published
- 2013-02-23
- Volume
- 13
- Issue
- 1
- Pages
- 86-86
- ISSN
- 1471-2407 (ISSN-L)
- PMC
- PMC3606618
- OpenAlex
- W2098047267
- Cited by
- 44
- References
- 46
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 7 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 1
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Cancer (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Physical Sciences › Chemistry › Organic Chemistry › Heterocyclic Compound Synthesis and Bioactivity
- Keywords
- albendazole, 2-methoxyestradiol, combination chemotherapy, microtubule inhibitors, drug synergy, colorectal cancer, HCT116 cells, prostate cancer, colchicine, apoptosis, extrinsic apoptotic pathway, microtubule assembly, anticancer activity, tumor-bearing nude mice
- MeSH terms
- 2-Methoxyestradiol, Animals, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Colchicine, Cytotoxins, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Synergism, Enzyme-Linked Immunosorbent Assay, Estradiol, Female, Humans, Male, Mice, Inbred BALB C, Mice, Nude, Prostatic Neoplasms, Colorectal Neoplasms, Albendazole, HCT116 Cells, Tubulin Modulators, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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