Albendazole and Praziquantel: Review and Safety Monitoring in Korea
Open accessAbstract
Albendazole (ADZ) and praziquantel (PZQT) have been used as anthelmintics for over 30 years. Worldwide, hundreds of millions tablets are administered to people and livestock every year. ADZ is poorly orally absorbed (<5%), and its uptake is enhanced by high-fat meals, while PZQT is well absorbed (>75%) and uptake is enhanced by carbohydrate-rich meals. Both ADZ and PZQT are safe, but not recommended for children <2 years or for women in the first trimester of pregnancy. Serious adverse events occur following high dose and prolonged administration of these drugs for treatment of echinococcosis or neurocysticercosis, especially in patients with poor liver function. The adverse events may be induced by the drugs, or by the dead worms themselves. The Korea Institute of Drug Safety & Risk Management monitors drug-related adverse events in Korea, and its database included 256 probable or possible ADZ-associated events and 108 PZQT-associated events between 2006 and 2015. Such low incidence rates in Korea are due to the low single dose treatments of ADZ, and the short-term use of PZQT. The number of serious adverse events due to drug interaction induced by ADZ and PZQT were six and two, respectively. We conclude that ADZ and PZQT are generally safe drugs, but they must be used with caution in people with poor liver function or those being comedicated for gastroesophageal reflux disease.
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Albendazole is contraindicated during pregnancy in humans.
“Albendazole is contraindicated during pregnancy in humans [3,11].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [11]
The Abstract and Conclusion say albendazole is not recommended in the first trimester, which supports avoiding it during part of pregnancy. But “Drug safety in pregnancy” says WHO has approved its use during pregnancy and describes it as sufficiently safe for certain uses; the paper does not support a blanket contraindication throughout pregnancy. (LLM, conf=0.85)
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Александровна, П. Е., Buyko, E. E., Ivanov, V. V., Ivanov, A. A., Korotchenko, N. V., & Удут, Е. В. (2026) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2025-4-220-231
Earthworm gut microbiome promotes biodegradation of albendazole in soil
Wang, J., Ge, H., Liu, Y., Huang, C., Zhang, L., Yu, Y., Xu, L., & Fang, H. (2026) · Crop Health · doi:10.1007/s44297-026-00068-5
El-Saidy, S. A., El-Feki, A. S., El‐Khodary, G. M., Hassan, A. A. A., Elgendy, D. I., & Gawaan, Y. M. (2026) · Scientific Reports · doi:10.1038/s41598-026-60075-y
Popova-Daskalova, G., Kostadinov, K. R., Eneva, K., Masarlieva, А. A., Vuchev, D., Uchikov, A., Aleksova, L., Nikolov, N., & Nedkova, T. (2026) · Biomedicines · doi:10.3390/biomedicines14081734
Rahdar, M., Rafiei, A., Safdarian, M., Makhmalzadeh, B. S., & Jahromi, K. F. (2026) · Jundishapur Journal of Natural Pharmaceutical Products · doi:10.5812/jjnpp-170836
- Authors
- Hong, S.-T.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Hong, Sung-Tae
- ORCID
- Hong, Sung-Tae
- Venue
- Infection & Chemotherapy
- Publisher
- XMLink
- Published
- 2018
- Volume
- 50
- Issue
- 1
- Pages
- 1
- ISSN
- 1598-8112 (ISSN-L)
- 2093-2340
- 2092-6448
- PMC
- PMC5895825
- OpenAlex
- W2793672935
- Cited by
- 65
- References
- 32
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 13 · 2021: 8 · 2020: 9 · 2019: 10
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Infection and Chemotherapy (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Seoul National University Hospital
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Parasitic infections in humans and animals
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- albendazole, praziquantel, anthelmintics, drug safety, adverse drug reactions, drug interactions, echinococcosis, neurocysticercosis, liver function, gastroesophageal reflux disease, pregnancy contraindication
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