The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
P4 Medicine: How Systems Medicine Will Transform the Healthcare Sector and Society
Open accessAbstract
Ten years ago, the proposition that healthcare is evolving from reactive disease care to care that is predictive, preventive, personalized and participatory was regarded as highly speculative. Today, the core elements of that vision are widely accepted and have been articulated in a series of recent reports by the US Institute of Medicine. Systems approaches to biology and medicine are now beginning to provide patients, consumers and physicians with personalized information about each individual's unique health experience of both health and disease at the molecular, cellular and organ levels. This information will make disease care radically more cost effective by personalizing care to each person's unique biology and by treating the causes rather than the symptoms of disease. It will also provide the basis for concrete action by consumers to improve their health as they observe the impact of lifestyle decisions. Working together in digitally powered familial and affinity networks, consumers will be able to reduce the incidence of the complex chronic diseases that currently account for 75% of disease-care costs in the USA.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Social relationships and health a flashpoint for health policy
Umberson, D., & Karas Montez, J. (2010) · Journal of Health and Social Behavior · doi:10.1177/0022146510383501 · Cited by 2,639
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
Grant, S. F. A., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Manolescu, A., Sainz, J., Helgason, A., Stefansson, H., Emilsson, V., Helgadottir, A., et al. (2006) · Nature Genetics · doi:10.1038/ng1732 · Cited by 2,287
Systems Biology and New Technologies Enable Predictive and Preventative Medicine
Hood, L., Heath, J. R., Phelps, M. E., & Lin, B. (2004) · Science · doi:10.1126/science.1104635 · Cited by 1,108
Self-citationWeston, A. D., & Hood, L. (2004) · Journal of Proteome Research · doi:10.1021/pr0499693 · Cited by 731
Self-citationComputational solutions to large‐scale data management and analysis
Schadt, E. E., Linderman, M. D., Sorenson, J., Lee, L., & Nolan, G. P. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2857 · Cited by 631
Molecular Stratification of Triple-Negative Breast Cancers
Perou, C. M. (2011) · The Oncologist · doi:10.1634/theoncologist.2011-s1-61 · Cited by 582
Increasing Physical Activity With Mobile Devices: A Meta-Analysis
Fanning, J., Mullen, S. P., & McAuley, E. (2012) · Journal of Medical Internet Research · doi:10.2196/jmir.2171 · Cited by 457
Evolution of Translational Omics: Lessons Learned and the Path Forward
Micheel, C., Nass, S. J., & Omenn, G. S. (2013) · Cited by 365
A systems approach to prion disease
Hwang, D., Lee, I. Y., Yoo, H., Gehlenborg, N., Cho, J., Petritis, B., Baxter, D., Pitstick, R., Young, R., Spicer, D., et al. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.10 · Cited by 287
Self-citationRevolutionizing medicine in the 21st century through systems approaches
Hood, L., Balling, R., & Auffray, C. (2012) · Biotechnology Journal · doi:10.1002/biot.201100306 · Cited by 252
Self-citation
Cited by
Plasma protein patterns as comprehensive indicators of health
Williams, S. A., Kivimaki, M., Langenberg, C., Hingorani, A. D., Casas, J. P., Bouchard, C., Jonasson, C., Sarzynski, M. A., Shipley, M. J., Alexander, L., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0665-2 · Cited by 506
Sharon, T. (2017) · Philosophy & Technology · doi:10.1007/s13347-016-0215-5 · Cited by 428
Personalised organs-on-chips: functional testing for precision medicine
van den Berg, A., Mummery, C. L., Passier, R., & van der Meer, A. D. (2019) · Lab on a Chip · doi:10.1039/c8lc00827b · Cited by 270
Big data in digital healthcare: lessons learnt and recommendations for general practice
Agrawal, R., & Prabakaran, S. (2020) · Heredity · doi:10.1038/s41437-020-0303-2 · Cited by 218
Research progress of CTC, ctDNA, and EVs in cancer liquid biopsy
Wang, X., Wang, L., Lin, H., Zhu, Y., Huang, D., Lai, M., Xi, X., Huang, J., Zhang, W., & Zhong, T. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1303335 · Cited by 112
Metadata
- Authors
- Flores, M., Glusman, G., Brogaard, K., Price, N. D., & Hood, L.
- Venue
- Personalized Medicine
- Publisher
- Informa UK Limited
- Published
- 2013-08
- Volume
- 10
- Issue
- 6
- Pages
- 565-576
- ISSN
- 1741-0541 (ISSN-L)
- 1744-828X
- OpenAlex
- W2088749788
- Cited by
- 616
- References
- 18
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: P4 Medicine: How Systems Medicine Will Transform the Healthcare Sector and Society. https://app.cochat.ai/papers/10.2217/pme.13.57
- The paper
- Flores, M., Glusman, G., Brogaard, K., Price, N. D., & Hood, L. (2013). P4 Medicine: How Systems Medicine Will Transform the Healthcare Sector and Society. Personalized Medicine. https://doi.org/10.2217/pme.13.57
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
