Personalised organs-on-chips: functional testing for precision medicine
Open accessAbstract
Organs-on-chips are microfluidic systems with controlled, dynamic microenvironments in which cultured cells exhibit functions that emulate organ-level physiology. They can in principle be 'personalised' to reflect individual physiology, for example by including blood samples, primary human tissue, and cells derived from induced pluripotent stem cell-derived cells, as well as by tuning key physico-chemical parameters of the cell culture microenvironment based on personal health data. The personalised nature of such systems, combined with physiologically relevant read-outs, provides new opportunities for person-specific assessment of drug efficacy and safety, as well as personalised strategies for disease prevention and treatment; together, this is known as 'precision medicine'. There are multiple reports of how to personalise organs-on-chips, with examples including airway-on-a-chip systems containing primary patient alveolar epithelial cells, vessels-on-chips with shapes based on personal biomedical imaging data and lung-on-a-chip systems that can be exposed to various regimes of cigarette smoking. In addition, multi-organ chip systems even allow the systematic and dynamic integration of more complex combinations of personalised cell culture parameters. Current personalised organs-on-chips have not yet been used for precision medicine as such. The major challenges that affect the implementation of personalised organs-on-chips in precision medicine are related to obtaining access to personal samples and corresponding health data, as well as to obtaining data on patient outcomes that can confirm the predictive value of personalised organs-on-chips. We argue here that involving all biomedical stakeholders from clinicians and patients to pharmaceutical companies will be integral to transition personalised organs-on-chips to precision medicine.
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Tumor-on-chip models can recreate human tumor microenvironments.
“Tumor-on-chip models based on these organ-on-chip systems can recreate human tumor microenvironments and now hold great promise as a new resource for cost-effective and higher-throughput screening of anticancer drugs [13,14,15,16,17] and powerful enablers of precision medicine [18].”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [18]
The Introduction says organs-on-chips recreate aspects of human tissue microenvironments and gives an example involving metastatic tumor cells in perfused vessels. It does not establish that tumor-on-chip models recreate the human tumor microenvironment as a whole. In the citing sentence, this source is cited for the separate point about precision medicine, which the paper discusses as a potential application. (LLM, conf=0.83)
Experimental — accuracy not yet measuredTumor-on-chip models are powerful enablers of precision medicine.
“Tumor-on-chip models based on these organ-on-chip systems can recreate human tumor microenvironments and now hold great promise as a new resource for cost-effective and higher-throughput screening of anticancer drugs [13,14,15,16,17] and powerful enablers of precision medicine [18].”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [18]
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- Authors
- van den Berg, A., Mummery, C. L., Passier, R., & van der Meer, A. D.
- Affiliations
- BIOS/Lab on a Chip
- Leiden University Medical Center (NL)
- University of Twente (NL)
- Applied Stem Cell Technologies
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 19
- Issue
- 2
- Pages
- 198-205
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- PMC
- PMC6336148
- OpenAlex
- W2902585499
- Cited by
- 270
- References
- 52
- Citations by year
- 2026: 20 · 2025: 28 · 2024: 36 · 2023: 30 · 2022: 44 · 2021: 57 · 2020: 40 · 2019: 15
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Lab on a Chip (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Twente Research Information (publishedVersion, cc-by)
- Leiden Repository (Leiden University) (submittedVersion, cc-by)
- Leiden Repository (Leiden University) (submittedVersion)
- University of Twente Research Information (submittedVersion, cc-by)
- Funders
- Dutch National Science Foundation (Gravitation Grant ‘NOCI’ Program, 024.003.001)
- H2020 European Research Council (VESCEL, 669768)
- FP7 Ideas: European Research Council (STEMCARDIOVASC, 323182)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- organ-on-a-chip, personalized medicine, precision medicine, microfluidic organ models, patient-derived cells, induced pluripotent stem cell-derived cells, alveolar epithelial cells, patient health data, predictive value, stakeholder collaboration
- MeSH terms
- Equipment Design, Humans, Tissue Array Analysis, Lab-On-A-Chip Devices, Precision Medicine
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