Exosomes derived from 3D-cultured MSCs alleviate knee osteoarthritis by promoting M2 macrophage polarization through miR-365a-5p and inhibiting TLR2/Myd88/NF-κB pathway
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MSC-Exos reduces the expression of proinflammatory cytokines in immune cells, diminishing inflammation-induced delays in bone healing and promoting bone tissue regeneration.
“Furthermore, MSC-Exos reduces the expression of proinflammatory cytokines in immune cells, thereby diminishing inflammation-induced delays in bone healing and promoting bone tissue regeneration [25,26].”
From Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation (2025) · cites this paper as [26]
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- Authors
- Yan, L., Li, D., Li, S., Jiao Li, J., Du, G., Liu, H., Zhang, J., Li, X., Fan, Z., Jiu, J., Li, R., Kong, N., Liu, W., Du, Y., & Wang, B.
- Affiliations
- Second Hospital of Shanxi Medical University (CN)
- Center for Life Sciences (CN)
- Shanxi Medical University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Corresponding author
- Du, Guangyuan
- Liu, Haifeng
- Liu, Wei
- Du, Yanan
- Wang, Bin
- Venue
- Chemical Engineering Journal
- Publisher
- Elsevier BV
- Published
- 2024-10
- Volume
- 497
- Pages
- 154432
- ISSN
- 1385-8947 (ISSN-L)
- OpenAlex
- W4401114835
- Cited by
- 20
- References
- 70
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 3
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Chemical Engineering Journal (publishedVersion)
- Funders
- National Natural Science Foundation of China (81802204)
- National Health and Medical Research Council (GNT1120249)
- Natural Science Foundation of Zhejiang Province (LTGY23H060007)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- mesenchymal stem cell-derived exosomes, knee osteoarthritis, 3D cell culture, M2 macrophage polarization, exosome yield, chondrocyte metabolism, cartilage damage, immunomodulation, rat osteoarthritis model
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