The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Collagen-Hydroxyapatite Composites for Hard Tissue Repair
Open accessAbstract
Bone is the most implanted tissue after blood. The major solid components of human bone are collagen (a natural polymer, also found in skin and tendons) and a substituted hydroxyapatite (a natural ceramic, also found in teeth). Although these two components when used separately provide a relatively successful mean of augmenting bone growth, the composite of the two natural materials exceeds this success. This paper provides a review of the most common routes to the fabrication of collagen (Col) and hydroxyapatite (HA) composites for bone analogues. The regeneration of diseased or fractured bones is the challenge faced by current technologies in tissue engineering. Hydroxyapatite and collagen composites (Col-HA) have the potential in mimicking and replacing skeletal bones. Both in vivo and in vitro studies show the importance of collagen type, mineralisation conditions, porosity, manufacturing conditions and crosslinking. The results outlined on mechanical properties, cell culturing and de-novo bone growth of these devices relate to the efficiency of these to be used as future bone implants. Solid free form fabrication where a mould can be built up layer by layer, providing shape and internal vascularisation may provide an improved method of creating composite structures.
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Cites
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Cited by
Bone Tissue Engineering: Recent Advances and Challenges
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Nanoscale hydroxyapatite particles for bone tissue engineering
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Bone substitutes in orthopaedic surgery: from basic science to clinical practice
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Extracellular matrix-based biomaterial scaffolds and the host response
Aamodt, J. M., & Grainger, D. W. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.02.003 · Cited by 509
Electrospun nanostructured scaffolds for bone tissue engineering
Prabhakaran, M. P., Venugopal, J., & Ramakrishna, S. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.05.007 · Cited by 430
Metadata
- Authors
- Department of Materials, U. O. O., Wahl, D., & Czernuszka, J.
- Venue
- European Cells and Materials
- Publisher
- Forum Multimedia Publishing LLC
- Published
- 2006-03-08
- Volume
- 11
- Pages
- 43-56
- ISSN
- 1473-2262 (ISSN-L)
- OpenAlex
- W2171727206
- Cited by
- 675
- References
- 74
- FWCI
- 17.31
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
