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Articular cartilage collagen: an irreplaceable framework?
Open accessAbstract
Adult articular cartilage by dry weight is two-thirds collagen. The collagen has a unique molecular phenotype. The nascent type II collagen fibril is a heteropolymer, with collagen IX molecules covalently linked to the surface and collagen XI forming the filamentous template of the fibril as a whole. The functions of collagens IX and XI in the heteropolymer are far from clear but, evidently, they are critically important since mutations in COLIX and COLXI genes can result in chondrodysplasia syndromes. Here we review what is known of the collagen assembly and present new evidence that collagen type III becomes covalently added to the polymeric fabric of adult human articular cartilage, perhaps as part of a matrix repair or remodelling process.
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Cited by
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Mobasheri, A., Rayman, M. P., Gualillo, O., Sellam, J., van der Kraan, P., & Fearon, U. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.50 · Cited by 742
Cell-laden hydrogels for osteochondral and cartilage tissue engineering
Yang, J., Zhang, Y. S., Yue, K., & Khademhosseini, A. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.036 · Cited by 652
Bourgot, I., Primac, I., Louis, T., Noël, A., & Maquoi, E. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01488 · Cited by 113
Metadata
- Authors
- University of Washington, D. O. O. A. S. M., Eyre, D., Weis, M., & Wu, J.-J.
- Venue
- European Cells and Materials
- Publisher
- Forum Multimedia Publishing LLC
- Published
- 2006-11-02
- Volume
- 12
- Pages
- 57-63
- ISSN
- 1473-2262 (ISSN-L)
- OpenAlex
- W2106298197
- Cited by
- 281
- References
- 0
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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