Anxiety disorders in childhood and adolescence: clinical and neurobiological aspects
Abstract
OBJECTIVE: This article reviews the clinical and epidemiological aspects of anxiety disorders in youngsters, as well as current medical and psychological treatment strategies. The role of the neurobiological models possibly involved in the etiology of these disorders is also discussed. SOURCES OF DATA: MEDLINE search of papers published in English from 1981 to 2003. The following key words were used: anxiety disorders, neurobiology, childhood, adolescence. SUMMARY OF THE FINDINGS: Childhood-onset anxiety disorders are among the most frequent psychiatric conditions in children and adolescents. Epidemiological data estimate a prevalence of 10% in this population. The neurobiological models involved in the etiology of anxiety disorders in youngsters are closely related to neuroimaging studies with individuals presenting these pathologies. The role of the amygdala in the pathophysiology of these disorders is underscored. To be effective, treatment must combine several interventions, such as cognitive-behavioral, family, and, frequently, drug treatments. CONCLUSIONS: Early identification and prompt treatment of anxiety disorders may prevent negative consequences, such as school absenteeism and frequent and unnecessary visits to pediatric services due to somatic complaints related to anxiety disorders. Moreover, it is possible that psychiatric problems could be avoided or attenuated in adulthood.
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Anxiety disorders can affect school dropout, excessive use of pediatric services, and the appearance of psychiatric disorders in adulthood.
“Anxiety disorders can affect school dropout, excessive use of pediatric services, given the somatic complaints related to anxiety, and the appearance of psychiatric disorders in adulthood, making social and family life more difficult. 29”
From Social isolation and its impact on child and adolescent development: a systematic review (2022) · cites this paper as [29]
Cites
Pine, D. S., Cohen, P., Gurley, D., Brook, J., & Ma, Y. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.1.56 · Cited by 1,753 · see citing works
Rauch, S. L., Whalen, P. J., Shin, L. M., McInerney, S. C., Macklin, M. L., Lasko, N. B., Orr, S. P., & Pitman, R. K. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00828-3 · Cited by 1,111 · see citing works
Identifying and developing empirically supported child and adolescent treatments.
Kazdin, A. E., & Weisz, J. R. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.66.1.19 · Cited by 754 · see citing works
Brain activation in PTSD in response to trauma-related stimuli
Liberzon, I., Taylor, S. F., Amdur, R., Jung, T. D., Chamberlain, K. R., Minoshima, S., Koeppe, R. A., & Fig, L. M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00246-7 · Cited by 635 · see citing works
Anxiety Disorders in Children and Adolescents
March, J. S. (2005) · Elsevier eBooks · doi:10.1016/b978-0-323-01199-0.50251-6 · Cited by 600 · see citing works
Effectiveness of psychotherapy with children and adolescents: A meta-analysis for clinicians.
Weisz, J. R., Weiss, B., Alicke, M. D., & Klotz, M. L. (1987) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.55.4.542 · Cited by 581 · see citing works
Lanius, R. A., Williamson, P. C., Densmore, M., Boksman, K., Gupta, M. A., Neufeld, R. W., Gati, J. S., & Menon, R. S. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1920 · Cited by 521 · see citing works
A 3-Year Follow-up of Children with and without Behavioral Inhibition
Biederman, J., Rosenbaum, J. F., Bolduc, E. A., Faraone, S. V., Chaloff, J., HIRSHFELD, D. R., & Kagan, J. (1993) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199307000-00016 · Cited by 516 · see citing works
The outcome of psychotherapy with children.
Casey, R. J., & Berman, J. S. (1985) · Psychological Bulletin · doi:10.1037/0033-2909.98.2.388 · Cited by 492 · see citing works
Temperament and the Reactions to Unfamiliarity
Kagan, J. (1997) · Child Development · doi:10.1111/j.1467-8624.1997.tb01931.x · Cited by 428 · see citing works
Cognitive-Behavioral and Pharmacological Treatments of Social Phobia: A Controlled Study
Gelernter, C. S. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810340070009 · Cited by 404 · see citing works
Uncommon Troubles in Young People:
Whitaker, A. H. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810170087013 · Cited by 403 · see citing works
A Prospective Study of Childhood Anxiety Disorders
Last, C. G., Perrin, S. G., Hersen, M., & Kazdin, A. E. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199611000-00019 · Cited by 390 · see citing works
Empirically supported treatments for children with phobic and anxiety disorders: Current status
Ollendick, T. H., & King, N. J. (1998) · Journal of Clinical Child Psychology · doi:10.1207/s15374424jccp2702_3 · Cited by 384 · see citing works
Anxiety Disorders in Children and Adolescents: A Review of the Past 10 Years
Bernstein, G. A., BORCHARDT, C. M., & Perwien, A. R. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199609000-00008 · Cited by 382 · see citing works
Fluoxetine for the Treatment of Childhood Anxiety Disorders
Birmaher, B. B., Axelson, D., Monk, K., Kalas, C., Clark, D. B., Ehmann, M., Bridge, J. A., Heo, J., & Brent, D. A. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000037049.04952.9f · Cited by 380 · see citing works
DSM-III-R Anxiety Disorders in Children: Sociodemographic and Clinical Characteristics
Last, C. G., Perrin, S. G., Hersen, M., & Kazdin, A. E. (1992) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199211000-00012 · Cited by 351 · see citing works
Anxiety Disorders in Children and Their Families
Last, C. G. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810340060008 · Cited by 341 · see citing works
Öst, L., Johansson, J., & Jerremalm, A. (1982) · Behaviour Research and Therapy · doi:10.1016/0005-7967(82)90066-3 · Cited by 338 · see citing works
Effectiveness of cognitive-behavior therapy for maladapting children: A meta-analysis.
Durlak, J. A., Fuhrman, T., & Lampman, C. B. (1991) · Psychological Bulletin · doi:10.1037/0033-2909.110.2.204 · Cited by 318 · see citing works
Propranolol Treatment for Childhood Posttraumatic Stress Disorder, Acute Type
Famularo, R. (1988) · American journal of diseases of children · doi:10.1001/archpedi.1988.02150110122036 · Cited by 298 · see citing works
Brain circuits in panic disorder
Coplan, J. D., & Lydiard, R. B. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00300-x · Cited by 195 · see citing works
Fredrikson, M., Wik, G., Annas, P., FRICSON, K., & Stone‐Elander, S. (1995) · Psychophysiology · doi:10.1111/j.1469-8986.1995.tb03404.x · Cited by 193 · see citing works
Bernstein, G. A., & Shaw, K. R. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199710001-00006 · Cited by 177 · see citing works
Social and simple phobias in children
Strauss, C. C., & Last, C. G. (1993) · Journal of Anxiety Disorders · doi:10.1016/0887-6185(93)90012-a · Cited by 173 · see citing works
Relationship between Separation Anxiety and Panic and Agoraphobic Disorders
Gittelman, R., & Klein, D. F. (2010) · Psychopathology · doi:10.1159/000284078 · Cited by 164 · see citing works
Current Knowledge of Medications for the Treatment of Childhood Anxiety Disorders
Allen, A. J., Leonard, H., & Swedo, S. E. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199508000-00007 · Cited by 149 · see citing works
Relationship of childhood anxiety to adult panic disorder: correlates and influence on course
Pollack, M. H., Otto, M. W., Sabatino, S. A., Majcher, D., Worthington, J. J., McArdle, E. T., & Rosenbaum, J. F. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.3.376 · Cited by 147 · see citing works
Somatic complaints in anxious children
Beidel, D. C., Christ, M. A. G., & Long, P. J. (1991) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf00918905 · Cited by 134 · see citing works
Current approaches to etiology and pathophysiology of specific phobia
Fyer, A. J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00274-1 · Cited by 101 · see citing works
Catechol O-Methyltransferase Genetic Polymorphism in Panic Disorder
Woo, J., Yoon, K., & Yu, B. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1785 · Cited by 101 · see citing works
Neurobiological perspectives on social phobia: from affiliation to zoology
Stein, M. B. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00265-0 · Cited by 99 · see citing works
Positive association between panic disorder and polymorphism of the serotonin 2A receptor gene
Inada, Y., Yoneda, H., Koh, J., Sakai, J., Himei, A., Kinoshita, Y., Akabame, K., Hiraoka, Y., & Sakai, T. (2003) · Psychiatry Research · doi:10.1016/s0165-1781(03)00064-7 · Cited by 85 · see citing works
Biological therapies for posttraumatic stress disorder: an overview.
Davidson, J. R. T. (1997) · PubMed · Cited by 83 · see citing works
Separation Anxiety and Overanxious Disorders: Relations to Age and Level of Psychosocial Maturity
Westenberg, P. M., Siebelink, B. M., WARMENHOVEN, N. J. C., & Treffers, P. D. A. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199908000-00016 · Cited by 66 · see citing works
New developments in childhood affective and anxiety disorders
Swedo, S. E., Leonard, H. L., & Allen, A. J. (1994) · Current Problems in Pediatrics · doi:10.1016/0045-9380(94)90023-x · Cited by 60 · see citing works
The Prevalence of Posttraumatic Stress Disorder in an Adolescent Inpatient Unit
Koltek, M., Wilkes, T. C., & Atkinson, M. J. (1998) · The Canadian Journal of Psychiatry · doi:10.1177/070674379804300107 · Cited by 57 · see citing works
Specific phobia and generalized anxiety disorder.
Silverman, W. K., & Ginsburg, G. S. (1995) · Cited by 22 · see citing works
Treatment of Anxiety Disorders of Childhood
Albano, A. M., & Chorpita, B. F. (1995) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30022-4 · Cited by 17 · see citing works
Heimberg, R. G., Mennin, D. S., & Jack, M. S. (1999) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1999)9:1 · Cited by 4 · see citing works
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Social isolation and its impact on child and adolescent development: a systematic review
Almeida, I. L. D. L., Rego, J. F., Teixeira, A. C. G., & Moreira, M. R. (2022) · Revista Paulista de Pediatria · doi:10.1590/1984-0462/2022/40/2020385 · Cited by 223 · see citing works
- Authors
- Asbahr, F. R.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Asbahr, Fernando R.
- Venue
- Jornal de Pediatria
- Publisher
- Jornal de Pediatria
- Published
- 2004-03-01
- Volume
- 80
- Issue
- 7
- Pages
- 28-34
- ISSN
- 0021-7557 (ISSN-L)
- DOI
- 10.2223/1166
- OpenAlex
- W3005663935
- Cited by
- 24
- References
- 40
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 8 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2012: 3
- FWCI
- 0.40
- Type
- journal article
- Language
- pt
- Open access
- closed
- Locations
- Jornal de Pediatria (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- childhood anxiety disorders, adolescent anxiety disorders, neurobiology of anxiety, amygdala, neuroimaging, prevalence, cognitive behavioral therapy, family therapy, pharmacotherapy, early detection, school absenteeism, somatic symptoms
- MeSH terms
- Adolescent, Anxiety Disorders, Child, Humans, Neurobiology, Cognitive Behavioral Therapy
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