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Cited by 521Posttraumatic Stress Disorder ResearchMemory Processes and InfluencesPsychoanalysis and Psychopathology Research

Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation

Lanius, Ruth A., Williamson, Peter C., Densmore, Maria, Boksman, Kristine, Gupta, Madhulika A., Neufeld, R.W., Gati, Joseph S., Menon, Ravi S.·2001·American Journal of Psychiatry
DOI 10.1176/appi.ajp.158.11.1920
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Abstract

OBJECTIVE: The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD. METHOD: Traumatized subjects with (N=9) and without (N=9) PTSD were studied by using the script-driven symptom provocation paradigm adapted to functional magnetic resonance imaging at a 4-T field strength. RESULTS: PTSD subjects showed significantly less activation of the thalamus, the anterior cingulate gyrus (Brodmann's area 32), and the medial frontal gyrus (Brodmann's area 10/11) than did the comparison subjects. CONCLUSIONS: The findings suggest anterior cingulate, frontal, and thalamic involvement in the neuronal circuitry underlying PTSD.

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  • A few studies have not found amygdala activation during symptomatic conditions in PTSD, possibly owing to issues associated with using a smaller sample.

    “though, a few studies have not found amygdala activation during symptomatic conditions in PTSD, possibly owing to issues associated with using a smaller sample (Bremner et al., 1999;Lanius et al., 2001).”

    From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Lanius et al., 2001

  • Lanius et al. (2001) found decreased rACC and medial frontal gyrus activation in a traumatic and baseline imagery condition in PTSD compared with traumatized individuals without PTSD.

    “Lanius and colleagues (Lanius et al., 2001) found decreased rACC and medial frontal gyrus activation in a traumatic and baseline imagery condition in PTSD compared with traumatized individuals without PTSD.”

    From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Lanius et al., 2001

  • The initial pilot studies describing alternating physiological reactions to individualized trauma scripts in chronic PTSD patients interpreted the data as supportive for two distinct subtypes 'each representing unique pathways to chronic stress-related psychopathology'.

    “The initial pilot studies describing alternating physiological reactions to individualized trauma scripts in chronic PTSD patients (Lanius et al., 2001; Lanius et al., 2002) interpreted the data as supportive for two distinct subtypes ‘each representing unique pathways to chronic stress- related psychopathology’ (Lanius et al., 2006, p. 710).”

    From Trauma-related dissociation and the autonomic nervous system: a systematic literature review of psychophysiological correlates of dissociative experiencing in PTSD patients (2022) · cites this paper as Lanius et al., 2001

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Authors
Lanius, R. A., Williamson, P. C., Densmore, M., Boksman, K., Gupta, M. A., Neufeld, R. W., Gati, J. S., & Menon, R. S.
Affiliations
Western University (CA)
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2001-11-01
Volume
158
Issue
11
Pages
1920-1922
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/appi.ajp.158.11.1920
OpenAlex
W2165540518
Cited by
521
References
1
Citations by year
2026: 5 · 2025: 16 · 2024: 7 · 2023: 12 · 2022: 16 · 2021: 13 · 2020: 18 · 2019: 28 · 2018: 23 · 2017: 18 · 2016: 21 · 2015: 15 · 2014: 25 · 2013: 26 · 2012: 21
FWCI
24.98
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
post-traumatic stress disorder, traumatic memory, neural correlates, thalamus, anterior cingulate cortex, medial frontal gyrus, neural circuits, brain activation
MeSH terms
Adult, Brain, Major Depressive Disorder, Depressive Disorder, Major, Female, Heart Rate, Humans, Magnetic Resonance Imaging, Male, Memory, Stress Disorders, Post-Traumatic, Comorbidity, Prevalence, Panic Disorder, Dysthymic Disorder, Substance-Related Disorders

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