A review on efficacy and tolerability of tea tree oil for acne
Open accessAbstract
Acne is common problem acquired generally after puberty. It ranges from mild to moderate: papules, pustules, nodules to severe cyst. Various natural therapy can be employed for treatment of acne including Tea tree oil (TTO). Tea tree oil has wide spectrum anti-microbial agent showing in treatment of acne. Usually it is utilized in various topical preparations. It contains more than 80-90% monoterpenes namely terpinen-4-ol, -cymene, α-terpinene, limonene 1,8-cineol, α-terpineol, terpinolene, 1,8-cineol, sabinene and α-pinene, The European cosmetic Association recommended not more than 1% use of tea tree oil in cosmetic preparations. In this review, we listed various efficacy and tolerability studies along with challenges in application of tea tree oil in cosmetics and dermatological preparations. TTO is a moderate sensitizer and upon oxidation it increases in its allergenic potency. This is a comprehensive review of using Tea tree oil against various microbial species. Various studies revealed the use of TTO as anti-bacterial, anti-fungal, anti- oxidant agent. TTO is effective treatment option that can further be utilized in preparation of novel formulations like liposomes, ethosomes along with combination with other anti-microbial and anti-oxidant agents. Keywords: Acne, Tea-tree oil, Application, Antioxidant, Nano particles.
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- [1]1. Ahmad S, Afsana , Popli H. A review on efficacy and tolerability of tea tree oil for acne. J. Drug Delivery Ther. [Internet]. 2019 May 15 [cited 2026 Oct. 11];9(3):609-12. Available from: https://jddtonline.info/index.php/jddt/article/view/2838 ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver AMA Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 9 No. 3 (2019): Volume 9, Issue 3, May-June 2019 Section Review Authors who publish with this journal agree to the following terms: Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). How to Cite
- [1]1. Ahmad S, Afsana , Popli H. A review on efficacy and tolerability of tea tree oil for acne. J. Drug Delivery Ther. [Internet]. 2019 May 15 [cited 2026 Oct. 11];9(3):609-12. Available from: https://jddtonline.info/index.php/jddt/article/view/2838 ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver AMA Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Crossref Scopus Google Scholar Europe PMC jddt Online ISSN: 2250-1177 Make a Submission Make a Submission categories Categories Aims & Scope Editorial Policies Publication Ethics Palgiarism Policy Retraction Policy Open Access Policy Processing Charges and Waiver Policy Indexing Latest publications Atom logo RSS2 logo RSS1 logo Announcements || Editorial Board || Indexing || Contact The publication is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) . View Legal Code
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- Authors
- Ahmad, S., Afsana, & Popli, H.
- Affiliations
- Delhi Pharmaceutical Science and Research University (IN)
- Venue
- Journal of Drug Delivery and Therapeutics
- Publisher
- Society of Pharmaceutical Tecnocrats
- Published
- 2019-05-15
- Volume
- 9
- Issue
- 3
- Pages
- 609-612
- ISSN
- 2250-1177 (ISSN-L)
- OpenAlex
- W3214500029
- Cited by
- 11
- References
- 42
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2020: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Drug Delivery and Therapeutics (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- tea tree oil, acne, monoterpenes, terpinen-4-ol, topical formulation, antimicrobial activity, antioxidant activity, allergenicity, liposomes, ethosomes, nanoformulations, natural medicine
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