The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: A randomized, double-blind placebo-controlled study
Open accessAbstract
BACKGROUND: Finding an effective treatment for acne that is well tolerated by the patients is a challenge. One study has suggested the efficacy of tea tree oil in treatment of the acne vulgaris. AIM: To determine the efficacy of tea tree oil in mild to moderate acne vulgaris. METHODS: This was a randomized double-blind clinical trial performed in 60 patients with mild to moderate acne vulgaris. They were randomly divided into two groups and were treated with tea tree oil gel (n=30) or placebo (n=30). They were followed every 15 days for a period of 45 days. Response to treatment was evaluated by the total acne lesions counting (TLC) and acne severity index (ASI). The data was analyzed statistically using t-test and by SPSS program. RESULTS: There were no significant differences regarding demographic characteristics between the two groups. There was a significant difference between tea tree oil gel and placebo in the improvement of the TLC and also regarding improvement of the ASI. In terms of TLC and ASI, tea tree oil gel was 3.55 times and 5.75 times more effective than placebo respectively. Side-effects with both groups were relatively similar and tolerable. CONCLUSION: Topical 5% tea tree oil is an effective treatment for mild to moderate acne vulgaris.
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Enshaieh et al. study on 5% topical tea tree oil gel for acne was a randomized, double-blind, placebo-controlled trial classified as Level 2b evidence and was limited by small sample size and short-term outcomes.
“The study design was a randomized, double‐blind, placebo‐controlled trial, which is considered Level 2b evidence according to the Oxford evidence hierarchy.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [18]
The Methods (pp. 1–2) describe a randomized, double-blind trial comparing 5% tea tree oil gel with placebo in 60 patients over 45 days. Those details substantiate the design and the short follow-up, but our copy does not classify the trial as Oxford Level 2b evidence or explicitly identify sample size and follow-up as limitations. (LLM, conf=0.86)
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Case Reports of Acne and Homeopathy
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ACNE-CAUSES AND AMAZING REMEDIAL MEASURES FOR ACNE
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Essential oils in cosmetics: Antioxidant properties and advancements through nanoformulations
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Garcinia mangostana hydrogel patch
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“Moreover, tea tree oil products, one of the popular topical anti-acne, also reported ACD (42) and side effects of treatment with minimal pruritus, burning, and scaling (43).”
BackgroundAn overview on the anti-acne properties of herbal essential oils
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Cosmetic Industry: Natural Secondary Metabolites for Beauty and Aging
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Exploiting Medicinal Plants as Possible Treatments for Acne Vulgaris
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A review on efficacy and tolerability of tea tree oil for acne
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A review of phytotherapy of Acne vulgaris
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“Few years ago, Enshaieh et al. (2007) confirmed the efficacy of 5% topical TTO gel in treatment of moderate acne vulgaris in a randomized, double-blind placebo-controlled study.”
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Phytochemicals as emerging therapeutics for acne vulgaris: a comprehensive review
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Over‐the‐Counter Acne Treatments
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Herbal medicine and common dermatologic diseases
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Volatile Oil Containing Plants as Phytopharmaceuticals to Treat Psoriasis: A Review
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- Authors
- Jooya, A., Siadat, A., Iraji, F., & Enshaieh, S.
- Affiliations
- Isfahan University of Medical Sciences (IR)
- ORCID
- Iraji, Fariba
- Venue
- Indian Journal of Dermatology, Venereology and Leprology
- Publisher
- Scientific Scholar
- Published
- 2007
- Volume
- 73
- Issue
- 1
- Pages
- 22
- ISSN
- 0378-6323 (ISSN-L)
- OpenAlex
- W2018583838
- Cited by
- 165
- References
- 9
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 11 · 2023: 13 · 2022: 9 · 2021: 13 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 11 · 2012: 13
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Indian Journal of Dermatology Venereology and Leprology (publishedVersion)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (submittedVersion)
- Bioline International (Bioline International) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- tea tree oil, topical gel, acne, mild to moderate acne, herbal medicine, treatment efficacy, tolerability
- MeSH terms
- Acne Vulgaris, Administration, Topical, Adolescent, Adult, Anti-Infective Agents, Local, Double-Blind Method, Female, Gels, Humans, Male, Severity of Illness Index, Treatment Outcome, Tea Tree Oil
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