The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
TNF.ALPHA. and pathologic bone resorption
Open accessAbstract
Chronic inflammatory bone diseases, such as rheumatoid arthritis, periodontal disease and aseptic periprosthetic osteolysis, are characterized by bone loss around affected joints and teeth caused by increased osteoclastic bone resorption. This resorption is mediated largely by the increased local production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNFa). These cytokines may induce resorption indirectly by affecting the production of the essential osteoclast differentiation factor, receptor activator of NF-kB ligand, and/or its soluble decoy receptor, osteoprotegerin, by osteoblast/stromal cells or directly by enhancing proliferation and/or activity of cells in the osteoclast lineage. The importance of TNFa in the pathogenesis of various forms of bone loss is supported by both experimental and clinical evidence. However, TNFa is not absolutely required for osteoclastogenesis, erosive arthritis, or osteolysis, as all these events could occur in the absence of TNFa and whether TNFa promotes osteoclast formation independently of RANK signaling is still a topic of debate. Here we review our current understanding of the mechanisms whereby TNFa increases osteoclastogenesis in vitro and in vivo.
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TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis.
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RANK Is the Essential Signaling Receptor for Osteoclast Differentiation Factor in Osteoclastogenesis
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Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α
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The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts.
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Cited by
Regulation of TNF-Induced Osteoclast Differentiation
Yao, Z., Getting, S. J., & Locke, I. C. (2021) · Cells · doi:10.3390/cells11010132 · Cited by 280
Self-citationHMGB1 Regulates RANKL-Induced Osteoclastogenesis in a Manner Dependent on RAGE
Zhou, Z., Han, J.-Y., Xi, C.-X., Xie, J.-X., Feng, X., Wang, C.-Y., Mei, L., & Xiong, W.-C. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080234 · Cited by 160
Vieira Ribeiro, F., de Mendonça, A. C., Santos, V. R., Bastos, M. F., Figueiredo, L. C., & Duarte, P. M. (2011) · Journal of Periodontology · doi:10.1902/jop.2011.100643 · Cited by 121
Bone diseases in patients with chronic liver disease
Jeong, H., & Kim, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174270 · Cited by 113
Contributors to impaired bone health in type 2 diabetes
Sheu, A., Greenfield, J. R., White, C. P., & Center, J. R. (2023) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2022.11.003 · Cited by 69
Msx2 mediates the inhibitory action of TNF-α on osteoblast differentiation
Lee, H.-L., Yi, T., Woo, K. M., Ryoo, H.-M., Kim, G.-S., & Baek, J.-H. (2010) · Experimental and Molecular Medicine · doi:10.3858/emm.2010.42.6.045 · Cited by 64
Metadata
- Authors
- Boyce, B. E., Li, P., Yao, Z., Zhang, Q., Badell, I. R., Schwarz, E. M., O’Keefe, R. J., & Xing, L.
- Venue
- The Keio Journal of Medicine
- Publisher
- Keio Journal of Medicine
- Published
- 2005
- Volume
- 54
- Issue
- 3
- Pages
- 127-131
- ISSN
- 0022-9717 (ISSN-L)
- 1880-1293
- OpenAlex
- W1984721683
- Cited by
- 259
- References
- 14
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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