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Cited by 42Effects of Radiation ExposureNausea and vomiting managementGastrointestinal motility and disorders

Characterization of radiation-induced emesis in the ferret

King, Gregory L.·1988·Radiation Research
DOI 10.2307/3577130
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Abstract

Forty-eight ferrets (Mustela putorius furo) were individually head-shielded and radiated with bilateral 60Co gamma radiation at 100 cGy min-1 at doses ranging between 49 and 601 cGy. The emetic threshold was observed at 69 cGy, the ED50 was calculated at 77 cGy, and 100% incidence of emesis occurred at 201 cGy. With increasing doses of radiation, the latency to first emesis after radiation decreased dramatically, whereas the duration of the prodromal period increased. Two other sets of experiments suggest that dopaminergic mechanisms play a minor role in radiation-induced emesis in the ferret. Twenty-two animals were injected either intravenously or subcutaneously with 30 to 300 micrograms/kg of apomorphine. Fewer than 50% of the animals vomited to 300 micrograms/kg apomorphine; central dopaminergic receptor activation was apparent at all doses. Another eight animals received 1 mg/kg domperidone prior to either 201 (n = 4) or 401 (n = 4) cGy radiation and their emetic responses were compared with NaCl-injected-irradiated controls (n = 8). At 201 cGy, domperidone significantly reduced only the total time in emetic behavior. At 401 cGy, domperidone had no salutary effect on radiation-induced emesis. The emetic responses of the ferret to radiation and apomorphine are compared with these responses in other vomiting species.

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Crossref · 10.2307/3577130

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  • In the ferret model, retching and vomiting occur at doses as low as 50 cGy and can be expected from SPE radiation exposure at doses up to 2 Gy.

    “Animal studies performed using a ferret model indicate that retching and vomiting occur at doses as low as 50 cGy and can be expected from SPE radiation exposure at doses up to 2 Gy [67,68].”

    From Space Radiation: The number one risk to astronaut health beyond low earth orbit (2014) · cites this paper as [67]

  • Emesis and retching are known prodromal outcomes following exposure to high doses of radiation.

    “Emesis and retching are known prodromal outcomes following exposures to high doses of radiation”

    From Space Radiation: The number one risk to astronaut health beyond low earth orbit (2014) · cites this paper as [67]

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Authors
King, G. L.
Corresponding author
King, Gregory L.
Venue
Radiation Research
Publisher
JSTOR
Published
1988-06
Volume
114
Issue
3
Pages
599
ISSN
0033-7587 (ISSN-L)
DOI
10.2307/3577130
OpenAlex
W1979194809
Cited by
42
References
33
Citations by year
2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 2
FWCI
1.20
Type
journal article
Language
en
Open access
closed
Locations
  • Radiation Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Surgery › Nausea and vomiting management
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
radiation-induced emesis, vomiting, ferrets, cobalt-60 gamma irradiation, dose-response relationship, apomorphine, dopaminergic mechanisms, domperidone, prodromal period
MeSH terms
Animals, Apomorphine, Carnivora, Cobalt Radioisotopes, Domperidone, Emetics, Ferrets, Gamma Rays, Male, Radiation Injuries, Experimental, Vomiting

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