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Radiobiology of α Particles: III. Cell Inactivation by α-Particle Traversals of the Cell Nucleus
Abstract
Cell inactivation after exposure to collimated 3.5-MeV alpha particles in three hamster cell lines, V79, CHO-10B, and HS-23, one mouse cell line, C3H 10T1/2, and a human skin fibroblast cell line were studied. Several parameters were investigated for each cell line. Theoretical calculations were performed to find the distribution of energy deposited in the nuclear volume for each cell line. The mean number of alpha-particle traversals required to induce a lethal lesion varied between two for HS-23 cells and six for C3H 10T1/2 cells. The number of traversals per unit area and the total track length of alpha particles that inactivated a cell were found to be nearly constant for the hamster and mouse cell lines. These quantities were found to be lower for the human skin fibroblast cell line. The RBE values for all cell lines were found to be about 3.8 at 10% survival. Thus cell lines that are more sensitive to alpha radiation are also more sensitive to gamma radiation. The average number of alpha-particle traversals producing a single lethal lesion is greater than one. The passages of alpha particles through the cell nucleus that do not kill the cell may lead to carcinogenic effects.
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Cited by
Sgouros, G., Roeske, J. C., McDevitt, M. R., Palm, S., Allen, B. J., Fisher, D. R., Brill, A. B., Song, H., Howell, R. W., & Akabani, G. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.058651 · Cited by 552
Azzam, E. I., de Toledo, S. M., Gooding, T., & Little, J. B. (1998) · Radiation Research · doi:10.2307/3579865 · Cited by 521
Radioimmunotherapy with alpha-emitting nuclides
McDevitt, M. R., Sgouros, G., Finn, R. D., Humm, J. L., Jurcic, J. G., Larson, S. M., & Scheinberg, D. A. (1998) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s002590050306 · Cited by 403
Friedrich, T., Scholz, U., ElsaSser, T., Durante, M., & Scholz, M. (2013) · Journal of Radiation Research · doi:10.1093/jrr/rrs114 · Cited by 287
An overview of targeted alpha therapy
Kim, Y.-S., & Brechbiel, M. W. (2012) · Tumor Biology · doi:10.1007/s13277-011-0286-y · Cited by 278
Metadata
- Authors
- Raju, M. R., Eisen, Y., Carpenter, S., & Inkret, W. C.
- Venue
- Radiation Research
- Publisher
- JSTOR
- Published
- 1991-11
- Volume
- 128
- Issue
- 2
- Pages
- 204
- ISSN
- 0033-7587 (ISSN-L)
- OpenAlex
- W2444395074
- Cited by
- 167
- References
- 0
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Raju, M. R., Eisen, Y., Carpenter, S., & Inkret, W. C. (1991). Radiobiology of α Particles: III. Cell Inactivation by α-Particle Traversals of the Cell Nucleus. Radiation Research. https://doi.org/10.2307/3578139
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