The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Intercellular Communication Is Involved in the Bystander Regulation of Gene Expression in Human Cells Exposed to Very Low Fluences of Alpha Particles
Abstract
We demonstrate by western analysis that the expression levels of TP53 (formerly known as p53), CDKN1A (formerly known as p21Waf1), CDC2 (formerly known as p34cdc2), CCNB1 (cyclin B1) and RAD51 are significantly modulated in confluent, density-inhibited human diploid cell populations exposed to doses where only a small fraction of the nuclei are actually traversed by an alpha-particle track. The extent of modulation of TP53 and CDKN1A is significantly reduced in the presence of the gap junction inhibitor lindane and in irradiated low-density cell populations. In situ immunofluorescence studies show that at doses where about 2% of the nuclei would be traversed by an alpha particle, induction of CDKN1A occurs in more cells than predicted. Furthermore, the induced cells are present in isolated aggregates of neighboring cells. Therefore, our studies at the gene expression level indicate that similar signaling pathways are induced in bystander cells that are not traversed by an alpha particle as in traversed cells, and that biological effects in cell populations are not restricted to the response of individual cells to the DNA damage they receive.
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Eckner, R., Ewen, M. E., Newsome, D., Gerdes, M., DeCaprio, J. A., Lawrence, J. B., & Livingston, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.8.869 · Cited by 1,045
Induction of sister chromatid exchanges by extremely low doses of alpha-particles.
Nagasawa, H., & Little, J. B. (1992) · PubMed · Cited by 995
Self-citationScrape-loading and dye transfer
El-Fouly, M. H., Trosko, J. E., & Chang, C.-C. (1987) · Experimental Cell Research · doi:10.1016/0014-4827(87)90014-0 · Cited by 662
Narayanan, P. K., Goodwin, E. H., & Lehnert, B. E. (1997) · PubMed · Cited by 461
Lorimore, S. A., Kadhim, M. A., Pocock, D. A., Papworth, D., Stevens, D. L., Goodhead, D. T., & Wright, E. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5730 · Cited by 303
Deshpande, A., Goodwin, E. H., Bailey, S. M., Marrone, B. L., & Lehnert, B. E. (1996) · Radiation Research · doi:10.2307/3578980 · Cited by 291
Radiobiology of α Particles: III. Cell Inactivation by α-Particle Traversals of the Cell Nucleus
Raju, M. R., Eisen, Y., Carpenter, S., & Inkret, W. C. (1991) · Radiation Research · doi:10.2307/3578139 · Cited by 167
Alpha-particle-induced p53 protein expression in a rat lung epithelial cell strain.
Hickman, A. W., Jaramillo, R. J., Lechner, J. F., & Johnson, N. (1994) · PubMed · Cited by 159
Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosis.
Kanemitsu, M. Y., Jiang, W. B., & Eckhart, W. (1998) · PubMed · Cited by 113
CDC2 is down-regulated by ionizing radiation in a p53-dependent manner.
Azzam, E. I., Toledo, S. D., Pykett, M. J., Nagasawa, H. T., & Little, J. B. (1997) · PubMed · Cited by 53
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Cited by
The Regulation of Exosome Secretion: a Novel Function of the p53 Protein
Yu, X., Harris, S. L., & Levine, A. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4579 · Cited by 688
Morgan, W. F. (2003) · Radiation Research · doi:10.1667/0033-7587(2003)159[0567:nadeoe]2.0.co;2 · Cited by 649
Sgouros, G., Roeske, J. C., McDevitt, M. R., Palm, S., Allen, B. J., Fisher, D. R., Brill, A. B., Song, H., Howell, R. W., & Akabani, G. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.058651 · Cited by 552
Radiation-Induced Bystander Effects: Past History and Future Directions
Mothersill, C., & Seymour, C. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)155[0759:ribeph]2.0.co;2 · Cited by 507
Induction of a bystander mutagenic effect of alpha particles in mammalian cells
Zhou, H., Randers-Pehrson, G., Waldren, C. A., Vannais, D., Hall, E. J., & Hei, T. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.030420797 · Cited by 477
Metadata
- Authors
- Azzam, E. I., de Toledo, S. M., Gooding, T., & Little, J. B.
- Venue
- Radiation Research
- Publisher
- JSTOR
- Published
- 1998-11
- Volume
- 150
- Issue
- 5
- Pages
- 497
- ISSN
- 0033-7587 (ISSN-L)
- OpenAlex
- W1981797176
- Cited by
- 521
- References
- 11
- FWCI
- 22.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Azzam, E. I., de Toledo, S. M., Gooding, T., & Little, J. B. (1998). Intercellular Communication Is Involved in the Bystander Regulation of Gene Expression in Human Cells Exposed to Very Low Fluences of Alpha Particles. Radiation Research. https://doi.org/10.2307/3579865
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