Tumorigenic Potential of High-Z, High-LET Charged-Particle Radiations

Cited by (177)

Items 101–177 of 177

  1. Initiation-promotion model of tumor prevalence in mice from space radiation exposures
    Francis A. Cucinotta, John W. Wilson · 1995 · Radiation and Environmental Biophysics
  2. DNA damage and repair in oncogenic transformation by heavy ion radiation
    Tracy Chui-hsu Yang, M. Mei, Kerry A. George, Laurie M. Craise · 1996 · Advances in Space Research
  3. New measurements for hadrontherapy and space radiation: biology.
    Eleanor A. Blakely · 2001 · PubMed
  4. Non-targeted effects and space radiation risks for astronauts on multiple International Space Station and lunar missions
    Francis A. Cucinotta · 2023 · Life Sciences in Space Research
  5. Once we know all the radiobiology we need to know, how can we use it to predict space radiation risks and achieve fame and fortune?
    F. A. Cucinotta · 2001 · PubMed
  6. An initiation-promotion model of tumour prevalence from high-charge and energy radiations
    F. A. Cucinotta, John W. Wilson · 1994 · Physics in Medicine and Biology
  7. Risk assessment for cancer induction after low- and high-LET therapeutic irradiation
    Hilde Engels, Hans G. Menzel, Pascal Pihet, André Wambersie · 1999 · Strahlentherapie und Onkologie
  8. Biophysics of NASA radiation quality factors
    Francis A. Cucinotta · 2015 · Radiation Protection Dosimetry
  9. Monte Carlo mixture model of lifetime cancer incidence risk from radiation exposure on shuttle and international space station
    Leif E. Peterson, Francis A. Cucinotta · 1999 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
  10. Risk of second cancer after ion beam radiotherapy: insights from animal carcinogenesis studies
    Tatsuhiko Imaoka, Mayumi Nishimura, Kazuhiro Daino, Masaru Takabatake, Hitomi Moriyama, Yukiko Nishimura, Takamitsu Morioka, Yoshiya Shimada, Shizuko Kakinuma · 2018 · International Journal of Radiation Biology
  11. Synergy theory for murine Harderian gland tumours after irradiation by mixtures of high-energy ionized atomic nuclei
    Edward Greg Huang, Yimin Lin, Mark D. Ebert, Dae Woong Ham, Claire Yunzhi Zhang, Rainer K. Sachs · 2019 · Radiation and Environmental Biophysics
  12. Radiation measured with different dosimeters during STS-121 space mission
    Dazhuang Zhou, E. Semones, Ramona Gaza, S. Johnson, N. Zapp, Mark D. Weyland, R. Rutledge, T. Lin · 2008 · Acta Astronautica
  13. Proton radiography for inline treatment planning and positioning verification of small animals
    J. Müller, Christian Neubert, Cläre von Neubeck, Michael A. Baumann, Mechthild Krause, W. Enghardt, Rebecca Bütof, Antje Dietrich, Armin Lühr · 2017 · Acta Oncologica
  14. Benchmarking risk predictions and uncertainties in the NSCR model of GCR cancer risks with revised low let risk coefficients
    Cucinotta, Francis A., Cacao, Eliedonna, Kim, Myung-Hee Y., Saganti, Premkumar B. · 2020 · Life Sciences in Space Research
  15. Efficient Repair of DNA Damage Induced by Heavy Ion Particles in Meiotic Prophase I Nuclei of Caenorhabditis elegans
    Takako Takanami, YONGZHAO ZHANG, HIDETOSHI AOKI, Tomoko Abe, Shigeo Yoshida, Hideyuki Takahashi, Saburo Horiuchi, Atsushi Higashitani · 2003 · Journal of Radiation Research
  16. Radiation effects on late cytopathological parameters in the murine lens relative to particle fluence
    F. Tao, Patricia Powers-Risius, Edward L. Alpen, C. Medvedovsky, J.C. David, Basil V. Worgul · 1994 · Advances in Space Research
  17. Cell cycle delay in murine pre-osteoblasts is more pronounced after exposure to high-LET compared to low-LET radiation
    Yueyuan Hu, Christine Elisabeth Hellweg, Christa Baumstark‐Khan, Günther Reitz, Patrick Lau · 2013 · Radiation and Environmental Biophysics
  18. Loss of p15/Ink4b accompanies tumorigenesis triggered by complex DNA double-strand breaks
    Cristel V. Camacho, Bipasha Mukherjee, Brian M. Mcellin, Liang-Hao Ding, Burong Hu, Amyn A. Habib, Xian‐Jin Xie, Chaitanya S. Nirodi, Debabrata Saha, Michael D. Story et al. · 2010 · Carcinogenesis
  19. Synergy Theory in Radiobiology
    Dae Woong Ham, Binglin Song, Jian Gao, Julien Yu, Rainer K. Sachs · 2017 · Radiation Research
  20. Suppression of the Later Stages of Radiation-Induced Carcinogenesis by Antioxidant Dietary Formulations
    Ann R. Kennedy, Jeffrey H. Ware, William W. Carlton, James G. Davis · 2011 · Radiation Research
  21. Simulating Space Radiation-Induced Breast Tumor Incidence Using Automata
    Anne‐Catherine Heuskin, A. I. Osseiran, Jonathan Tang, Sylvain V. Costes · 2016 · Radiation Research
  22. Radiation and Radiation Disorders
    Jeffrey A. Jones, Fathi Karouia, Lawrence S. Pinsky, Octav Cristea · 2019 · Springer eBooks
  23. Quantitative Image Analysis of Laminin Immunoreactivity in Skin Basement Membrane Irradiated with 1 GeV/nucleon Iron Particles
    Sylvain V. Costes, Charles H. Streuli, Mary Helen Barcellos‐Hoff · 2000 · Radiation Research
  24. Managing Lunar and Mars Mission Radiation Risks
    Francis A. Cucinotta, Myung‐Hee Y. Kim, Lei Ren · 2005 · NASA Technical Reports Server (NASA)
  25. NON-TARGETED EFFECTS LEAD TO A PARIDIGM SHIFT IN RISK ASSESSMENT FOR A MISSION TO THE EARTH’S MOON OR MARTIAN MOON PHOBOS
    Cucinotta, Francis A, Cacao, Eliedonna, Kim, Myung-Hee Y, Saganti, Premkumar B · 2019 · Radiation Protection Dosimetry
  26. Mouse genomic associations with in vitro sensitivity to simulated space radiation
    Egle Cekanaviciute, Duc Tran, Hung Nguyen, Alejandra Lopez Macha, Eloise Pariset, Sasha A. Langley, Giulia Babbi, Sherina Malkani, Sébastien Penninckx, Jonathan Cummings Schisler et al. · 2022 · Life Sciences in Space Research
  27. Mixed Beam Murine Harderian Gland Tumorigenesis: Predicted Dose-Effect Relationships if neither Synergism nor Antagonism Occurs
    Nopphon Siranart, Eleanor A. Blakely, Alden Cheng, Naval Handa, Rainer K. Sachs · 2016 · Radiation Research
  28. Modeling Radiation-Induced Neoplastic Cell Transformation In Vitro and Tumor Induction In Vivo with the Local Effect Model
    Antonia Hufnagl, Michael Scholz, Thomas Friedrich · 2021 · Radiation Research
  29. Flying without a Net: Space Radiation Cancer Risk Predictions without a Gamma-ray Basis
    Francis A. Cucinotta · 2022 · International Journal of Molecular Sciences
  30. Neurocytotoxic effects of iron-ions on the developing brain measured in vivo using medaka (Oryzias latipes), a vertebrate model
    Takako Yasuda, Shoji Oda, Hiroshi Yasuda, Yusuke Hibi, Kazunori Anzai, Hiroshi Mitani · 2011 · International Journal of Radiation Biology
  31. THE IMPACT OF THE NEW BIOLOGY ON RADIATION RISKS IN SPACE
    John F. Dicello · 2003 · Health Physics
  32. Space Radiobiology
    Christine Elisabeth Hellweg, Carmen Arena, Sarah Baatout, Bjorn Baselet, Kristina Beblo‐Vranesevic, Nicol Caplin, Richard Coos, Fabiana Da Pieve, Veronica De Micco, Nicolas Foray et al. · 2023 · Springer eBooks
  33. Protons and High-Linear Energy Transfer Radiation Induce Genetically Similar Lymphomas With High Penetrance in a Mouse Model of the Aging Human Hematopoietic System
    Rutulkumar Patel, Luchang Zhang, Amar B. Desai, Mark James Hoenerhoff, Lucy H. Kennedy, Tomas Radivoyevitch, Chiara La Tessa, Stanton L. Gerson, Scott M. Welford · 2020 · International Journal of Radiation Oncology*Biology*Physics
  34. Absorption Characteristics of Protons and Photons in Tissue
    John F. Dicello · 2007 · Technology in Cancer Research & Treatment
  35. Tumor induction in mice after local irradiation with single doses of either carbon-ion beams or gamma rays
    Koichi Andō, Sachiko Koike, Yasushi Ohmachi, Yutaka Ando, Gén Kobashi · 2014 · International Journal of Radiation Biology
  36. Rejoining kinetics of G1-PCC breaks induced by different heavy-ion beams with a similar LET value
    Chizuru Tsuruoka, Yoshiya Furusawa, Kazunori Anzai, Ryuichi Okayasu, Masao Suzuki · 2010 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
  37. Novel apparatus to measure hyperthermal heavy ion damage to DNA: Strand breaks, base loss, and fragmentation
    Lamia Sellami, S. Lacombe, Darel John Hunting, J. Richard Wagner, Michael A. Huels · 2007 · Review of Scientific Instruments
  38. Assessing Nonlinearity in Harderian Gland Tumor Induction Using Three Combined HZE-irradiated Mouse Datasets
    Lori J. Chappell, S. Robin Elgart, Caitlin M. Milder, E. Semones · 2020 · Radiation Research
  39. Rad-Bio-App: a discovery environment for biologists to explore spaceflight-related radiation exposures
    Richard John Barker, Sylvain V. Costes, Jack Miller, Samrawit Gebre, Jonathan Lombardino, Simon Gilroy · 2021 · npj Microgravity
  40. Influence of Cell Position Relative to Planar Alpha-Particle Sources on Survival and Preneoplastic Transformation of Primary Rat Tracheal Epithelial Cells
    Margaret Terzaghi-Howe, John R. Ford, James E. Turner · 1996 · Radiation Research
  41. Modelling Cellular Response to Ionizing Radiation: Mechanistic, Semi-Mechanistic, and Phenomenological Approaches – a Historical Perspective
    Reza Taleei, Shirin Rahmanian, Hooshang Nikjoo · 2024 · Radiation Research
  42. Comparison between PHITS and GEANT4 Simulations of the Heavy Ion Beams at the BEVALAC at LBNL and the Booster Accelerator at BNL
    Sungmin Pak, Francis A. Cucinotta · 2021 · Life Sciences in Space Research
  43. The Influence of Mutation Induction in Normal Human Fibroblasts Irradiated with X Rays and Iron Ions
    Chizuru Tsuruoka, Masao Suzuki, Yoshiya Furusawa, Kazunori Anzai, Ryuichi Okayasu · 2009 · Biological Sciences in Space
  44. Accelerating space radiation countermeasure development through drug repurposing
    Madrid, P.B., Chang, P.Y. · 2022 · Life Sciences in Space Research
  45. Effects of 1 GeV/nucleon56Fe Particles on Longevity, Carcinogenesis and Neuromotor Ability inAtm-Deficient Mice
    Mitsuko Lynn Yamamoto, Kurt Hafer, Ramune Reliene, Sheila M. Fleming, Owen Joseph Kelly, Katrin Hacke, Robert H. Schiestl · 2010 · Radiation Research
  46. Space radiation research in the new millenium--from where we come and where we go.
    Jürgen Kiefer · 2001 · PubMed
  47. Single-track effects and new directions in GCR risk assessment
    Stanley B. Curtis · 1994 · Advances in Space Research
  48. Modeling of ionizing radiation-induced chromosome aberration and tumor prevalence based on two classes of DNA double-strand breaks clustering in chromatin domains
    Lei Zhao, Tang Aiping, Fei Long, Dong Mi, Yeqing Sun · 2023 · Ecotoxicology and Environmental Safety
  49. A Microdosimetric Dose Response Model for Monoenergetic Ions and Doses Relevant for Space Radiation Carcinogenesis
    Tony C. Slaba, Floriane Poignant, Shirin Rahmanian · 2025 · Radiation Research
  50. Tumor aggressiveness is independent of radiation quality in murine hepatocellular carcinoma and mammary tumor models
    Eshwar B. Udho, Shane M. Huebner, Dawn M. Albrecht, Kristina A. Matkowskyj, Linda J. Clipson, Catigan A. Hedican, Rachel Koth, Santina Snow, Emily L. Eberhardt, Devon D. Miller et al. · 2021 · International Journal of Radiation Biology
  51. Modelling the HPRT-gene mutation induction of particle beams: systematic in vitro data collection, analysis and microdosimetric kinetic model implementation
    A. Attili, Emanuele Scifoni, Francesco Tommasino · 2022 · Physics in Medicine and Biology
  52. High Linear Energy Transfer Radiation Effects
    Edward L. Alpen · 1998 · Elsevier eBooks
  53. DNA break clustering as a predictor of cell death across various radiation qualities: influence of cell size, cell asymmetry, and beam orientation
    Floriane Poignant, Eloise Pariset, Ianik Plante, Artem L. Ponomarev, Trevor Evain, Louise Viger, Tony C. Slaba, Steve R. Blattnig, Sylvain V. Costes · 2024 · Integrative Biology
  54. Heavy-Ion-Induced Lung Tumors: Dose- & LET-Dependence
    Polly Y. Chang, James P. Bakke, Chris J. Rosen, Kathleen A. Bjornstad, Jian‐Hua Mao, Eleanor A. Blakely · 2022 · Life
  55. Is delayed genomic instability specifically induced by high-LET particles?
    Isabelle Testard, Laure Sabatier · 1998 · Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms
  56. Annex B and All references
    2007 · Annals of the ICRP
  57. Results of nDOSE and HiDOSE Experiments for Dosimetric Evaluation During STS-134 Mission
    Mariagabriella Pugliese, Filomena Loffredo, Maria Quarto, Vincenzo Roca, Cristina Mattone, Oscar Borla, A. Zanini · 2014 · Microgravity Science and Technology
  58. Radiobiology and Hadron Therapy
    Eleanor A. Blakely, Manjit K. Dosanjh · 2018 · CRC Press eBooks
  59. Nitric Oxide Is Involved in Heavy Ion-Induced Non-Targeted Effects in Human Fibroblasts
    Megumi Hada, Premkumar B. Saganti, Francis A. Cucinotta · 2019 · International Journal of Molecular Sciences
  60. Preclinical Radiobiology and Predictive Assays
    Eleanor A. Blakely, Polly Y. Chang · 2011 · Biological and medical physics series
  61. DNA break clustering inside repair domains predicts cell death and mutation frequency in human fibroblasts and in Chinese hamster cells for a 10 3 x range of linear energy transfers
    Eloise Pariset, Ianik Plante, Artem L. Ponomarev, Louise Viger, Trevor Evain, Steve R. Blattnig, Sylvain V. Costes · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  62. A multilevel probabilistic dose response model for radiation-induced Harderian gland tumor prevalence–single beam and mixed field effects
    Xiaojing Xu, Steve R. Blattnig, Tony C. Slaba · 2025 · Life Sciences in Space Research
  63. The influence of shielding on the biological effectiveness of accelerated particles for the induction of chromosome damage
    Kerry A. George, Francis A. Cucinotta · 2007 · Advances in Space Research
  64. Of Men and Mice: Using Terrestrial Radiation Epidemiology Methods to Inform Analysis of Animal Models for Space Radiation Risk Assessment
    Lori J. Chappell, Katherine M. Rahill, S. Robin Elgart · 2023 · Radiation Research
  65. Radiation in Space: The Biology
    Christine Elisabeth Hellweg, Daniel Matthiä, Thomas Berger, Christa Baumstark‐Khan · 2020 · SpringerBriefs in space life sciences
  66. Reply to D. E. Watt, A. S. Alkharam, M. B. Child and M. S. Salikin, "Dose as a Damage Specifier in Radiobiology for Radiation Protection." A Comment on "Dose" (Radiat. Res. 137, 410-413, 1994)
    Robert Katz · 1994 · Radiation Research
  67. Kinetics Model for Initiation and Promotion for Describing Tumor Prevalence From HZE Radiation
    A Cucinotta Francis, Walter John · 2003 · NASA Technical Reports Server (NASA)
  68. Radiation quality and tissue-specific microenvironments following exposure to 1 GeV/AMU Fe
    Sylvain V. Costes, Mary Helen Barcellos‐Hoff · 2002 · Advances in Space Research
  69. Effects of space-relevant radiation on pre-osteoblasts
    Yueyuan Hu · 2014 · elib (German Aerospace Center)
  70. Non-Targeted Effects and the Dose Response for Heavy Ion Tumorigenesis
    Lori J. Chappell, Francis A. Cucinotta · 2010 · NASA STI Repository (National Aeronautics and Space Administration)
  71. Radiation Shielding Issues in Highly Inclined Low Earth Orbits
    John W. Wilson, F. A. Cucinotta, Jack Miller · 1996 · SAE technical papers on CD-ROM/SAE technical paper series
  72. Risk Assessment for Cancer Induction after Low- and High-LET Therapeutic Irradiation
    Gerhard Kraft · 1999
  73. Stochastic Effects — Radiation Carcinogenesis
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  74. Modelling neoplastic cell transformation and tumour induction for charged particles with the local effect model
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  75. Comparison of different quality factor models for space radiation protection
    Alexis Papadopoulos, Ioanna Kyriakou, G. Santin, Petteri J. Nieminen, Dalong Pang, W. B. Li, Ioannis A. Daglis, S. Incerti, Dimitris Emfietzoglou · 2026 · Radiation and Environmental Biophysics
  76. An ensemble dose-response model for monoenergetic ions and doses relevant for space radiation carcinogenesis
    Tony C. Slaba, Floriane Poignant · 2026 · Life Sciences in Space Research
  77. Cancer Risk from Exposure to Galactic Cosmic Rays - Implications for Human Space Exploration
    Francis A. Cucinotta, marco Durant · 2006 · NASA Technical Reports Server (NASA)