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Cited by 100Indigenous Cultures and HistoryLatin American history and cultureColonialism, slavery, and trade

The DOI matches its Crossref record.

Native People of Southern New England, 1500-1650

Weinstein, Laurie, Bragdon, Kathleen J.·1997·Ethnohistory
DOI 10.2307/483046
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Abstract

The hypothalamus is a crucial integrative center in the central nervous system, responsible for the regulation of homeostatic activities, including systemic energy balance. Increasing evidence has highlighted a critical role of astrocytes in orchestrating hypothalamic functions; they participate in the modulation of synaptic transmission, metabolic and trophic support to neurons, immune defense, and nutrient sensing. In this context, disturbance of systemic energy homeostasis, which is a common feature of obesity and the aging process, involves inflammatory responses. This may be related to dysfunction of hypothalamic astrocytes. In this regard, the aim of this study was to evaluate the neurochemical properties of hypothalamic astrocyte cultures from newborn, adult, and aged Wistar rats. Age-dependent changes in the regulation of glutamatergic homeostasis, glutathione biosynthesis, amino acid profile, glucose metabolism, trophic support, and inflammatory response were observed. Additionally, signaling pathways including nuclear factor erythroid-derived 2-like 2/heme oxygenase-1 p38 mitogen-activated protein kinase, nuclear factor kappa B, phosphatidylinositide 3-kinase/Akt, and leptin receptor expression may represent putative mechanisms associated with the cellular alterations. In summary, our findings indicate that as age increases, hypothalamic astrocytes remodel and exhibit changes in their neurochemical properties. This process may play a role in the onset and/or progression of metabolic disorders.

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Metadata

Authors
Weinstein, L., & Bragdon, K. J.
Venue
Ethnohistory
Publisher
JSTOR
Published
1997
Volume
44
Issue
3
Pages
577
ISSN
0014-1801 (ISSN-L)
DOI
10.2307/483046
OpenAlex
W2163426048
Cited by
100
References
0
Citations by year
2025: 1 · 2022: 1 · 2021: 10 · 2020: 4 · 2019: 11 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 1
FWCI
8.03
Type
journal article
Language
en
Open access
closed
Locations
Ethnohistory (publishedVersion)
Topics
  • Social Sciences › Anthropology › Indigenous Cultures and History
  • Social Sciences › Arts and Humanities › History › Latin American history and culture
  • Social Sciences › Arts and Humanities › History › Colonialism, slavery, and trade
Keywords
Native Americans, indigenous peoples, colonial period, early modern period, southern New England, Native American-European relations, Wampanoag, Pequot, Mohegan, Narragansett

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